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Flashcards in STI Deck (45)
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1

What are some common presentations of STI

discharges from mouth or genital, genital lesions, warts

2

What is the typical presentation of Neisseria gonorrhoea in men?

urethral discharge, pain due to clogged up urethra

3

What are some presentation of Neisseria gonorrhoea with oral sex

pharyngitis, lymphadenopathy

4

T/F Neisseria gonorrhoea is a gram +ve rod

False, it is gram -ve cocci

5

What is the target adhesion site of Neisseria gonorrhoea

the columnar epithelial cells in urethra or cervix

6

Why is Neisseria gonorrhoea infection more common in younger women?

Older women have squamous lining on cervix, offering more protection

7

What does the histology of Neisseria gonorrhoea swab look like?

packed with neutrophils with phagocytosed diplococci

8

What is the typical presentation of Neisseria gonorrhoea in female?

asymptomatic

9

What is the reason for the increasing resistance of Neisseria gonorrhoea

exchange of genetic material with Neisseria in mouth during oral sex

10

What is Fitz-Hugh-Curtis Syndrome?

A disseminated symptom of gonorrhoea, which involves bacteria ascending up the fallopian tube to infect around the liver

11

T/F Gonorrhoea is the most common STI

False, it is second to Chlamydia

12

What is the presentation of pelvic inflammatory disease?

tubal scarring + increased risk of infertility, fever, pelvic tenderness, discharge

13

T/F Babies are subjected to gonorrhoea infection if the mum is infected

True, they are exposed during delivery, typically presents with purulent/scarring/perforation of cornea and blindness

14

Why must we diagnose babies with gonorrhoea before any treatment?

We treat gonorrhoea with IV Cefotaxime, but if it's other bacterial infection, we can just use topical antibiotic

15

What is a better way to diagnose gonorrhoea (better than swab)

First void specimen

16

What must we do when we culture Neisseria gonorrhoea

Use selective agar to inhibit normal flora to avoid lost of pathogen in the background

17

T/F PCR of STI diagnosis routinely combines gonorrhoea and Chlamydia

True. It's not as specific for gonorrhoea as there may be cross reaction with Neisseria spp.

18

What is the treatment of gonorrhoea

Ceftriaxone (cephelosporin), working on cell wall
Azithromycin, working on 50s ribosome

19

T/F vaccine is available for Neisseria gonorrhoea

False

20

Which part of the Chlamydia cycle is infectious

Elementary bodies, which live outside the cells. Chlamydia is an obligate intracellular organism

21

What is serovar (of Chlamydia)

they are serological variants, a way to characterise Chlamydia infections

22

What does the elementary body turn into once it infects a cell?

reticulate body, which replicates and rupture into large numbers

23

What is the presentation of Chlamydia in men

dysuria, meatal erythema (redness at tip of penis), clear urethral discharge, testicular pain, prostatitis

24

What is the difference between discharge from Chlamydia and gonorrhoea?

Chlamydia - clear
Gonorrhoea - thick and obvious

25

Chlamydia is usually asymptomatic in women, but what are the possible symptoms?

cervicitis
endometriosis
vaginal discharge, dysuria, pelvic pain if bacteria ascends

26

Describe the process of Chlamydia Lymphogranuloma venereum (LGV)

Chlamydia can spread to local lymph nodes in a few weeks to cause a lot of suppuration. If not drained, they can cause fistula

27

What are the possible symptoms of a baby infected with Chlamydia during delivery

conjunctivitis within 2 weeks
delayed pneumonia with staccato cough

28

Why do we do follow up tests with patients treated for Chlamydia

there is a chance of reinfection or there may be a lack of response to initial treatment

29

What are the options of treatment Chlamydia

Azithromycin or Doxycycline

Avoid doxycycline for pregnant women

30

T/F Trochomonas vaginalis is a gram +ve bacteria

False, it's a parasite with interesting mobility