Ch 106 Cardiac surgery Flashcards
(73 cards)
Which coronary artery is dominant in dogs and cats?
Dogs - left
Cats - right
What is the first brach of the aortic arch?
Second?
Brachiocephalic trunk
Second = Left subclavian artery
anatomy
- The right and left atria are divided by an atrial septum and receive blood from the systemic and pulmonary venous circulations, respectively
- Blood is carried from the systemic circulation to the right atrium by the cranial and caudal vena cava
- azygos vein usually drains into the cranial vena cava
- cr. and ca. vena cava, azygous and the right atrium are readily accessible from the right lateral aspect
- Blood is carried to the left atrium by multiple pulmonary veins
- right atrioventricular (tricuspid) and left atrioventricular (mitral) valves
- The pericardium contains several sinuses and recesses.78 Under normal conditions, a minimal amount of fluid (0.5–1 mL in the dog) is present
- This fluid, produced by the visceral pericardial cells, is an ultrafiltrate of plasma and provides lubrication to facilitate normal movements between the epicardium and pericardium without friction.
- The atrioventricular valves composed of leaflets, chordae, and papillary muscles
- pulmonic and aortic valves (semilunar valves)
- the pulmonic valve and main pulmonary artery are accessible from the left lateral aspect of the heart
- he left and right vagus nerves run at the level of the heart base,
- left and right phrenic nerves run over the pericardium at the level of the coronary groove.
- The left recurrent laryngeal nerve originates from the left vagus at the level of the ductus or ligamentum arteriosum,
What factors determine stroke volume?
Preload
Afterload
Contractility
Cardiac Cycle and Pressure-Volume Relationship
- During each cardiac cycle, the heart accomplishes two fundamental kinds of external work. It generates pressure and it ejects volume
- pressure-volume plot: filling phase, an isovolumetric contraction phase, an ejection phase, and an isovolumetric relaxation phase.
- cardiac filling is divided into rapid diastolic filling (passive) and atrial filling (atrial systole).
- The principal volume endpoints are end-diastolic volume (EDV) and end-systolic volume (ESV). The difference between EDV and ESV is the stroke volume (SV).
Cardiac Output, Blood Pressure, and Vascular Resistance
- CO = SV and HR
- MAP = (CO x VR) + AP
- vascular resistance = vasoconstriction (i.e., vascular radius) in the resistance arteries and the viscosity of blood (i.e., hematocrit)
- pulse pressure (Pp) is the difference between the systolic and diastolic blood pressures.
- ## It is possible to have a high pulse pressure and strong pulse but a low mean arterial pressure and vice versa (PDA or aortic insufficiency,)
Electrophysiology
- Cardiomyocytes are excitable cells with a negative resting membrane potential and the ability to generate an action potential.
- predominant mechanisms supporting resting membrane potential are the electrochemical gradient for K+ across the sarcolemma established by the ATPase Na+-K+ pump
- Entry of Ca2+ into the cell during the action potential initiates contraction of the cardiomyocyte (i.e., excitation-contraction coupling).
- cardiac impulse arises from automatic (pacemaker) cells within the sinoatrial node.
- travels leftward and ventrally as a uniform wave across the atrial muscle, initiating atrial systole.
- The impulse enters the atrioventricular node and is delayed by nodal cells that conduct slowly
- atrioventricular node and is selectively conducted to the endocardial portion of the ventricular myocardium by the very fast conducting His-Purkinje conduction system > initiating ventricular systole.
AV blocks
What kinds of cardiac procedures can be performed under venous inflow occlusion?
Short procedures under 4 minutes
Anesthesia
- opioid and a benzodiazepine
- Acepromazine should generally be avoided > prolonged hypotension.
- alpha-2 agonists cause significant cardiovascular depression
- balanced protocols consisting of combinations of an inhalant; an opioid, such as fentanyl; a benzodiazepine and a neuromuscular blocking agent, such as atracurium
For what amount of time can circulatory arrest be allowed for in normotheric and hypothermic animals (32-34C)?
Normothermic - 2min
Hypothermic - 4min
What is the lowest allowable temperature for hypothermic cardiac surgery?
32C - under this the risk of v-fib increases significantly
What vessels are tourniqueted for inflow occlusion?
right or left thoracotomy
Caudal vena cava
Cranial vena cava
Azygous vein
WHat is the maximal time for aortic cross clamping during cardiac bypass?
90min
What is the main post-op complications of cardiac bypass?
SIRS
Cardiopulmonary Bypass
- an extracorporal system provides flow of oxygenated blood to the patient, resulting in a motionless and bloodless operative field
- accomplished with a heart-lung machine (three to five pumps, a temperature-controlled circulating heater/cooler water bath, an oxygen blender, a gas flowmeter, and an anesthetic vaporizer)
- Arterial cannulation of a carotid or femoral artery is preferred over direct aortic cannulation in dogs
- Blood is diverted from the right heart to the cardiopulmonary bypass circuit by means of one or two venous cannulas through a venous line.
- Bicaval venous cannulation
- cavoatrial cannula through the right auricle
- Hemodilution is desirable during cardiopulmonary bypass to counter the effects of increased blood viscosity during hypothermia (alculated volume of crystalloid solution.)
- anticoagulation by administration of heparin
- goal of maintaining a venous oxygen saturation of 70% or greater and normal lactate concentrations
- Mean arterial pressure, which should be 50 to 70 mm Hg during bypass
- (FiO2) should be adjusted to keep PaO2 above 120 mm Hg during cardiopulmonary bypass.
- complete cardiac arrest is accomplished by cross-clamping the ascending aorta (reduce risk of air embolism)
- Protection of myocardium by cardioplegia solutions (high concentration of K+ that arrests the electrical and mechanical activities, cooling to 4C)
- The heart must be de-aired before discontinuing bypass. This is accomplished by diverting venous blood back
- The heart must be de-aired before discontinuing bypass. This is accomplished by diverting venous blood back
- Protamine administered to reverse the heparin anticoagulation
Effects of Cardiopulmonary Bypass
Systemic Inflammatory Response:
- CPB triggers an inflammatory reaction, especially within the first 12 hours post-surgery. This can lead to hemorrhage, hypoxemia, circulatory collapse, arrhythmias, low urine output, and electrolyte imbalances.
Hemorrhage:
- Even with proper surgical closure, biologic effects of CPB (e.g., thrombocytopenia, coagulopathy) can lead to significant bleeding.
- Management includes careful inspection, supportive care, and administration of fresh whole blood to restore clotting factors.
Hypoxemia & Pulmonary Injury:
- CPB increases pulmonary vascular permeability, causing “pump lung” (postoperative hypoxemia).
- PEEP (5-8 cm H₂O) for 4-12 hours post-surgery helps manage this.
Circulatory Support:
- Volume expansion is needed to maintain central venous pressure (4-10 mmHg) and cardiac output.
- Plasma or blood is preferred over crystalloids to restore volume, keeping hematocrit above 30%.
Other Postoperative Concerns:
- Inotropic support may be needed for cardiac output and blood pressure maintenance.
- Ventricular tachycardia is common and can be controlled with lidocaine.
- Urine output must be monitored for 12 hours, with hypokalemia and hypocalcemia being frequent complications.
Patent Ductus Arteriosus
- fetal vessel that connects the main pulmonary artery to the descending aorta and directs venous blood away from the collapsed fetal lungs.
- It closes soon after birth during the transition from fetal to extrauterine life.
- Over time, the ductus should transform into a ligamentum
- PDA most common congenital heart defect seen in dogs
- persistant 6th aortic arch
What breeds are predisposed to PDA?
Poodles, Keeshonds, Maltese, Bichon, Yorkies, cokers etc
Heritable component in Corgis and Poodles (hypoplasia and segmental asymmetry of the ductus muscle mass that results in failure of ductus contraction
Pathophysiology
- left-to-right shunting of blood from the aorta to the pulmonary artery
- severe volume overload of the left heart, leading to left ventricular and atrial dilatation and left-sided congestive heart failure, mitral regurgitation +/- atrial fibrillation
- untreated > die from progressive heart failure before 1 year of age
- some develop suprasystemic pulmonary hypertension that reverses the direction of flow through the shunt,
- result in hypoxemia and cyanosis that is more intense in the caudal portions of the body (differential cyanosis).
- Right-to-left patent ductus arteriosus may develop as a late sequela
What causes a reverse PDA?
Supresystemic pulmonary hypertension
daignosis
left-to-right patent ductus arteriosus
- mild exercise intolerance or stunted growth
- left-sided heart failure and include severe activity intolerance, cough, exertional tachypnea, or dyspnea
- continuous murmur at the left heart base with or without continuous cardiac thrill
- Femoral pulses are bounding or hyperkinetic because of low diastolic pressures caused by shunting of blood
- RADS: left atrial and ventricular enlargement, enlargement of pulmonary vessels, and a characteristic dilatation of the descending aorta on the dorsoventral view
- Echocardiography is confirmatory and helps rule out concurrent cardiac defects (characteristic pattern of reverse turbulent flow in the pulmonary artery on Doppler)
right-to-left
- exercise intolerance and pelvic limb collapse
- Classically, the cyanosis is “differential” (i.e., more severe in the caudal mucous membranes
- usually no cardiac murmur
- polycythemia
What age is recommended for surgical treatment of a PDA?
Older than 8 weeks and younger than 16 weeks
PDA surgical options
- percutaneous placement of embolization coils
- Amplatz Canine Ductal Occluder (ACDO) devices
- surgical ligation
Even animals with severe secondary myocardial failure and functional mitral regurgitation will benefit from surgery.
surgical ligation of a right-to-left PDA is contraindicated.