Ch 31 Cervical vertebral column Flashcards

(118 cards)

1
Q

What CN deficits can be seen with a C1-C5 lesion?

A

Positional strabysmus and/or facial hyperaesthesia with C1-C3
v. rare!

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2
Q

What is Horners Syndrome?
What spinal cord segment can cause this?
What is the path of the sympathetic nerves?

A

Horners syndrome is loos of sympathetic innervation to the eye causing miosis, ptosis, enophthalmos and elevation of the third eyelid
T1-T3
Hypothalamus -> descends sp. cord in lateral tectotegmental tracts

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3
Q

Why do dogs with cervical lesions often present with more pronounced motor dysfunction in the pelvic limbs?

A

The descending UMN tracts to the pelvic limbs are more peripherally located within the spinal cord

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4
Q

C1-C5 CS

A
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5
Q

C6-T2

A

difference in stride length between the thoracic and pelvic limbs is sometimes called a two-engine gait.

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6
Q

Ventral Approach to the Cervical Vertebral Column

paramedian

A

right sternocephalicus muscle is separated from the right sternohyoideus muscle (Figure 31.3). The sternohyoideus muscles are then retracted to the left with the trachea, esophagus, and carotid sheath.

protect the trachea, right recurrent laryngeal nerve, and the contents of the right carotid sheath

decreasing the likelihood of hemorrhage from the right caudal thyroid artery.

exposure of the longus colli muscles (D) and the longus capitis muscles

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7
Q

right carotid sheath (3)

A

vagosympathetic trunk
carotid artery
internal jugular vein

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8
Q

Ventral Approach to the Atlantoaxial Articulation

What are the benefits of the right parasagittal?

What surgical landmark can be used for ventral C1-C2

right-sided parasagittal approach

A

advantages: improved exposure of the joint avoidance of dissection thyroid gland, trachea, and recurrent laryngeal nerve.
improved ability to drill or drive a Kirschner wire across the right C1-C2 articulation without the larynx and trachea directly adjacent

mandible to a point at least 5 cm caudal to the caudal edge of the thyroid cartilage

right sternothyroideus and sternocephalicus muscles and the right carotid sheath are then exposed and separated, exposing the paired longus colli muscles and cervical vertebrae

retraction of the right carotid sheath to the left side

locating a pointed ventral prominence, the ventral tubercle, on the caudal aspect of C1

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9
Q

Lateral Approach to the Cervical Vertebral Column

lateral or foraminal IVDE, as well as nerve sheath neoplasms

A

Articular processes of C3-C6 are palpated to serve as a landmark

Platysma
Blunt seperation through brachiocephalicus
Splenius
Serratus vantralis
Plane of dissection between longissimus capitus and complexus muscles to expose articular facet
Dorsal branch of the spinal nerve needs to be sacrificed, the tendinous attachments of the complexus and multifidus are then detached from the articular process
Longissimus capitus sharply dissected from transverse process and reflected ventrally to fully expose the joints
C5-C7 requires seperation of brachiocephalicus from trapezium (not dissection through). The superficial cervical artery and vein will be located between these muscles and is ligated

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10
Q

Lateral Approach to the Brachial Plexus

What muscle do the spinal nerves of the brachial plexus lie deep to?

A

Scalenus muscle

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11
Q

Atlantoaxial Instability

A

leads to compression and contusion of the cervical spinal cord, resulting from displacement of the vertebrae (subluxation) into the vertebral canal;

atlantoaxial subluxation results from a ligamentous and/or osseous abnormality

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12
Q

AA anatomy

neurovascular paths?

Movement at this joint is mainly rotational,

A

First cervical spinal nerve and its associated vasculature pass through the lateral vertebral foramen

he vertebral artery enters the vertebral canal through the lateral vertebral foramen, after first having run through the transverse foramen of the atlas

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13
Q

How many pairs of foramina does the atlas have?

A

Two
- Transverse foramen - passes obliquely through transverse process
- Lateral vertebral foramen - perforates the craniodorsal part of the vertebral dorsal arch. First cervical spinal nerve and its associated vasculature run through here

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14
Q

How many bony elements for the atlas and axis develop from?
How long does it take for fusion?

A

Atlas - 3 boney elements
Axis - 7 boney elements (pair of arches, 3 parts of the body, the dens, apical elements of the dens)
Fusion of dorsal atlas by 106d, ventral suture by 115d
Fusion of all parts of axis from 30 - 396d

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15
Q

List the stabilising ligaments of the AA joint

dens = Odontoid process

A

Transverse ligament - holds the dens within the ventral aspect of the vertebral foramen. Prevents dorsal movement which allowing rotation

Apical ligament - attachs dens to basioccipital bone

Bilateral alar ligaments - Attach dens to the occipital condyles

Dorsal atlantoaxial ligament - Joins dorsal arch of atlas to craniodorsal spine of axis

Alar ligaments provide the most important stabilisation against VD shearing forces

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16
Q

List possible congenital or developmental abnormalities of the AA joint

Traumatic atlantoaxial subluxation can occur in dogs of any breed

A

Dysplasia (34%)
Hypoplasia or aplasia (46%)
Dorsal angulation of the dens
Seperation of the dens
Absense of the transverse ligament
Incomplete ossification of the atlas
Block vertebrae

Spinal cord trauma secondary to an acute episode of subluxation has the same underlying pathophysiology as that related to acute disc extrusion and acute vertebral fracture-luxation.

tear ligaments of fracture dens

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17
Q

What percentage of dogs with AA sublux will have a normal dens?

A

24%

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18
Q

What breeds are predisposed to congenital abnormalities predisposing to AA instability?

A

Yorkies
Chihuahuas
Min Poodles
Poms
Pekingese
Standard Poodles! - inherited ansense/hypoplasia of the dens

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19
Q

What is predictive of AA instability on a plain lateral radiograph?

A

An angle between the atlas and axis of less than 162 degrees

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20
Q

CT and MRI

A

CT can assist with identification of dens conformation or the presence of a fracture of the dens or vertebra, as well as with deciding on appropriate size of implants and surgical implant placement

MRI can provide additional information regarding spinal cord pathology such as hemorrhage or edema and syrin­gohydromyelia, which might be important for prognosis . Additionally, MRI enables visualization of the ligamentous and supporting structures

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21
Q

AA Tx: conservative
what?
how long?
how sccessful?

A

abilize the atlantoaxial articulation while the ligamentous structures heal

strict cage confinement for 6 weeks, analgesia
external coaptation ideally using a rigid cervical brace.

splint must immobilize the occipitoatlantoaxial articulation > must come over the head rostral to the ears and extend caudal to the level of the cranial aspect of the thorax.

Complications
recurrence of disease
corneal ulcers,
migration of the splint
moist dermatitis and decubital ulcers, hyperthermia,
respiratory compromise
otitis externa,

nonsurgical or conservative approaches are likely to result in recurrent or progressive clinical signs.

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22
Q

AA surgery
dorsal - what not achieved
ventral -advanatges?

goal = align and stabilize AA, prevent further spinal cord damage

A

Dorsal
Osseous fusion generally is not achieved > cannot resist movement in directions other than flexion
continuous movement, more likely failure of implants is associated with recurrence of clinical signs

Ventral
advantage of creating a bony ankylosis providing permanent joint fusion
odontoidectomy can be performed if required

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23
Q

What is a contraindication for dorsal stabilisation of AA sublux?
What are the advantages of ventral stabilisation?

A

Dorsal deviation of the dens

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24
Q

Dorsal techniques for AA stabilisation (5) and their associated long term success rates

A

Atlantoaxial wiring/dorsal loop wiring - 52%
loop needs to be folded back toward the axis, and at this time risk for iatrogenic trauma to the spinal cord

Double stranded cross-suturing (less than 2kg) - 50%

nuchal ligament technique - 75%

Dorsal cross-pinning

Kishigami AA tension band - 75%

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25
What is this device? What are its advantages?
Kishigami tension band for dorsal stabilisation of AA sublux Reduced risk of damaging the spinal cord as it does not need to be passed under the dorsal arch
26
List the ventral stabilisation techniques for AA subluxation and their associated long-term success rates (4) | articular cartilage can be scarified. This can encourage bony ankylosis
Transarticular screws or pins - 47% Pins and PMMA - 94% (long-term complications 34%) Screws and PMMA (placed 30-40 degrees) Ventral plating (mini H-plate 2.0mm, 5-hole butterfly plate 1.5mm)
27
What is the mean optimal AA insertion angle of transarticular screw/pin insertions? What was the mean corridor length and width?
**40+/-1** degree in medial to lateral direction **20+/-1** degree in VD direction from ventral aspect of vertebral foramen of the axis Mean corridor length 7mm, width 3-5mm AIming in a craniolateral direction
28
What is the overall rate of complications for dorsal and vental stabilisation of AA sublux?
Dorsal 71% Ventral 53% Implant failure of the transarticular pins most common complications. Implant failure 48% dorsal vs 44% ventral, may or may not require re-op Fracture of the Atlas or Axis The dorsal arch of the atlas can fracture following a dorsal stabilization techniqu Episodic pain has been reported in dogs for several months to life postoperatively Improper pin placement with inadequate bone purchase is the main cause of implant migration. Implant failure can be an incidental finding at recheck post-op nsaid, monitor, restrict 4-8wks | another surgery may not be necessary, > strong fibrous or osseous union.
29
What are the known risk factors effecting surgical outcome for AA stabilisation
**Age**of onset: Dogs under 24m had greater odds of successful outcome **Duration**and severity of clinical signs: Under 10m associated with greater odds of successful outcome
30
AA Px conservative? mortality rate?
conservative: good long-term outcome has been documented in 10 of 26 (38%) cases perioperative mortality rate: 4% and 30% of dogs
31
Biomechanical evaluation of two dorsal and two ventral stabilization techniques for atlantoaxial joint instability in toy-breed dogs **Progin 2021**
4 techniques (dorsal wire, modified dorsal clamp kishigami, ventral transarticular pin, and augmented ventral transarticular pin fixation). experimental (13 skull) The AAJs with dorsal wire, ventral transarticular pin, and augmented ventral transarticular pin fixations had similar biomechanical properties, but not clamp. load cycling and clinical studies are needed
32
Atlanto-axial ventral stabilisation using 3D-printed patient-specific drill guides for placement of bicortical screws in dogs **Toni 2020**
To report outcome and complications following atlanto-axial stabilisation by polymethylmethacrylate applied to screws placed using 3D-printed patient-specific drill guides. Materials and Methods: Case series Of 61 bicortical screws placed, 57 (93%) were fully contained rate of vertebral canal screw penetration of 7% in this study compares favourably to previously reported values of 21% and 9% using similar patient-specific guides **stainless steel screws resulting in greater CT artefact then would have occurred with titanium screws**
32
Determination of cutoff values on computed tomography and magnetic resonance images for the diagnosis of atlantoaxial instability in small-breed dogs Bastien Planchamp 2022
ventral compression index: ratio between ventral and dorsal atlantodental interval - VCI ≥0.16 in extension (100% sens, 94.5% spec) ≥0.2 in flexion (100%, 96.7%)
33
Computed Tomography and Biomechanical Comparison between Trans-Articular Screw Fixation and 2 Polymethylmethacrylate Cemented Constructs for Ventral Atlantoaxial Stabilization Guillaume Leblond 2018
cadavers The CT data revealed that TSF achieved significantly better apposition than cemented constructs 4.4% were graded as dangerous and 86.8% as optimal.
33
Planchamp 2021 – transarticular imaging measurements dependent on head-neck position - recommended standardised 50° flexion for measurements | VCOT
34
Determination of cutoff values on computed tomography and magnetic resonance images for the diagnosis of atlantoaxial instability in small-breed dogs Bastien Planchamp 2022
Study design: Retrospective multicenter study. Sample population: Client-owned dogs (n = 123) and 28 cadavers. ventral compression index (VCI f ≥0.16 in extended and ≥0.2 in flexed head positions were diagnostic for AAI (sensitivity of 100% and 100%, specificity of 94.54% and 96.67%, respectively).
35
The location of the endotracheal tube tie can influence interpretation of MR images of the craniocervical region of small breed dogs Dorsal compression of the cervical spinal cord can be identified by examining the cervical subarachnoid space at the atlantoaxial (AA) or atlantooccipital region using MRI. Dorsal compressive lesions have been described with various terms, such as AA constrictive lesions, dural fibrous bands, or AA bands,
These dorsal compressive lesions, identified with MRI, are a significant predictor of craniocervical junction abnormalities, such as atlantooccipital and AA instability, atlantooccipital overlap,
36
In what percentage of dogs does the C5 spinal cord segment contribute to the brachial plexus?
24%
37
What nerves are branches of the brachial plexus? (8)
Brachiocephalic Suprascapular Subscapular Axillary Musculocutaneous Radial Median Ulnar Dorsal thoracic Lateral thoracic Long thoracic Pectoral Muscular branches
38
Class 1: Neurapraxia - interruption of the function and conduction of a nerve without structural changes. Reversible, up to 6 weeks to improve Class 2: Axonotmesis - crush or percussion injuries causing Wallerian degeneration. Internal architecture of the nerve, including the endoneurium and Schwann sheath is well preserved. Recovery expected but can take several weeks Class 3: Neurotmesis - Disruption of axons and endoneurium but fascicular orientation is maintained by intact perineurium Class 4: Neurotmesis - Disrupted perineurium Class 5: Neurotmesis - Entire nerve severed neurotmesis: Full recovery usually not seen and accompanied by scar.
39
nerve roots lack an epineurium, traction of the thoracic limb or severe abduction of the scapula can result in stretching or avulsion of these nerve roots, usually within the dura dorsal root = sensory input into the spinal cord ventral root = motor function and autonomic innervation.
myelin sheath for each myelinated axon is formed by Schwann cell plasma membranes wrapping around the axon like an “onion peel.” The Schwann cells are separated by junctions called nodes of Ranvier, which assist in the rapid conduction of action potentials along the axon. Endoneurium surrounds each axon Groups of axons are surrounded by perineurium tissue around the entire nerve, called the epineurium
40
What are the 3 forms of brachial plexua injury and their common associated signs? | Unless avulsion confirmed, traction trauma to this region is appropriate
Injury of the **cranial portion (C5-C7)** - Effects musculocutaneous, axillary, subscapular and suprascapular nerves. Loss of shoulder movement and elbow flexion, shoulder atrophy Injury to the **caudal potion (C8-T2)**- Radial, median and ulnar nerves. Cannot extened elbow and thererfore cannot weight bear. Radial nerve involved in 92% of dogs. Can sometimes see Horners syndrome and loss of cutaneous trunci **Complete injury (C6-T2)** - Drags leg knuckles, shoulder more ventral, hypotonic and atrophy If the injury is severe > damage the spinal cord - **ipsilateral pelvic limb** general proprioceptive ataxia - UMN paresis or plegia.
41
WHat is indicative of a poor prognosis on EMG?
Early decreased radial nerve conduction velocity indicates a poor prognosis Electromyography allows detection of abnormal spontaneous electrical activity indicative of denervated muscles 1 week to 10 days after injury
42
surgical techniques for brachial plexus repair
Neurotization (nerve transfer) - Can be neuroneural or neuromuscular using 9-0 monofilament nylon Reimplantation via hemilaminectomy, durotomy, incision into pia mater and spinal cord Successful neurotization in cats using right lateral thoracic and thoracodorsal nerve to reinnervate the left transected musculocutaneous nerve adult dog, this **axonal regrowth** can reach at least 10 to 15 cm within a 4-month period
43
Brachial avulsion Px
grave if radial nerve avulsion occurs Carpal arthrodesis or tendon transposition > triceps innervation is required to be able to bear weight through the elbow given at least 4 to 6 weeks before a grave prognosis Limb amputation should be discussed if self-mutilation becomes apparent and is not responsive
44
What percentage of IVDH are cervical? What type? breed? | pathophysiology of spinal cord concussion and compression
14-25% most type I extrusion smll.chondrodys breeds or Labs, doberman, dalmation
45
most common sites of cervical disc herniation in chondrodystrophic dogs?
80% C2-C4 44-59% C2-C3 Caudal disc spaces are more common in Yorkies and Chihuahuas as well as large breeds
46
IVD anatomy where widest IVD? What is AF function? AF thickest where? how AF connect to bone? | AF = bands of parallel fibers that run obliquely, near IVD become cartil
every intervertebral space (except between C1 and C2), uniting the bodies of adjacent vertebrae to form amphiarthrodial joints the widest cervical intervertebral spaces are C4-C5 and C5-C6; the narrowest is C2-C3. AF > provide a means for transmission of stresses and strains required by all lateral and upward movements. one and a half to three times thicker ventrally than dorsally hyaline cartilaginous end plates cover the epiphyses of the vertebral bodies > attached to annular lamellae, a continuation of the Sharpey fibers
47
vertebral ligaments (4) | internal vertebral venous plexus along the floor of the vertebral canal
Dorsal longitudinal (dorsal to AF) thickest in the cervical vertebral column, offering greater resistance to dorsal herniation of nucleus pulposus material ventral longitudinal epidural space ventral yellow (ligamentum flava) interspinous and supraspinous
48
differentials (9)
FCE AA CSM MUO Noeplasia Fracture/luxation Disco cyst syringohydromyelia
49
cervical IVD CS what % have LMN C1-5?
45% acute, hyperaethesia 90%, 60% minimal signs (dt larger canal) nerve root signature 34% LMN cor C1-5 in msall dogs respiratory comromise > paresis/paralysis of resp. muscles causes hypoventilation
50
cervical IVD dx
1. CSF 2. rads: rule out disco/#/malformation. Narrow IVd/mineralisation (25% accuracy) 3. myelogram CT: heterogenous, hyperattenuating extradural mass with loss of epidural fat. possible compression inversely proprtional to ppst-op neuro status 4. MRI: nonivasive, high res image with increase localisation accuracy compared to CT. degree of compresion not prognostic. Hypointense on T2W ID hydrated IVD (hyperintense, seagull)
51
conservative TX cervical IVD aim? what % reccur | Levin 2007
enables resolution of the inflammation and stabilization of the ruptured intervertebral disc by fibrosis, preventing further herniation 4-6 weeks rest meds | 36% recurrence
52
What is chemonucleolysis?
Intradiscal injection of chondroitinase ABC to treat disc herniation. 92% of dogs improved with 77% having excellent improvement
53
indications for cervical IVD sx
severity or progressive fail to respond to medical unremitting pain finances
54
pros' and cons of ventral approach
Pros - remove disc easier - minimal muscle dissection - prophylactic fenesrtation cons - haemorrhage - poor field of view - reduced exposure for lateral/foramen disc
55
pros of dorsal approach
pros - provide increased decompression - better lateral access
56
V-slot maximum sizes of a ventral slot window? haemostasis? | Roerig 2013
modified paramedian approach: protect trachea, sheath and recurrent n. and reduce bleed from thyroid a. 33% length of vertebral body 50% width (but preferably 33%) excessive may lead to instability ad subluxation haemorrhage: cool avage, wax, gelatin sponge, macerated muscle | most residual compression post CT
57
What are the advantages of a slanted slot? What are the recommened window sizes?
Provides access at the site of herniation without removing a large portion of the annulus, thereby preserving more stability Window: 20% width and 20-25% length
58
What are the reported complication rates of v-slot? 10% 0verall (7) | what spaces phrenic n originate?
9.9% complications, 6.4% of which are major Mean mortality 3-8% Respiratory compromise (**phrenic nerve C5-C7**) > hypovent + aspiration Cardiac dysrhythmmias (VPC) dt near sheath Haemorrhage (18.9%) Neuro deterioration > excessive manipulation, horners, layngeal paralysis Instability (8% when width 50%) seroma
61
dorsal laminectomy hemilainectomy
dorsal multifidus elevated, pinous and yellow lig removaed laminectomy extended 75% not include articular process Hemi indicated in lateral disc
62
fenestration AIkawa 2012 Harris 2020 | prophylactic rather than sole Tx
A: shoud prevent further extrusion therefore reduce recurrence H: 30% new disc materila into canal in TL - unable to check if V-slot may exacerbate bulging in Type II collapse of sublux (major controbutor to stability > not recommended if >30kg
63
What has been shown to be associated with prognosis for cervical IVDH? more recent brazil study
Site: caudal to C3-C4 have poorer prognosis (likely included Wobblers) single vs lutli vlsot not affect outcome (Gou 2020) Degree of injury: LMN dysfunction, presence of VMF not predicitive non-ambulatory ~70% recovery Duration of disease: Able to walk within 96hr are likely to make a full recovery, dogs that do not walk within 2 weeks are likely to have residual deficits Type of Tx: 36% recurrency with conservative vs 5-10% surgical brazil: 10% recurrence v-slot 90% full recovery 1m and 98% (60% caudal in large breed) hemilam 80% at 12m, outcome better with Type I small breed than type II large breed hihger complication with v-slot but longer recovery wtih slanted slot, Hansen type II good and excellent in 47% and 32%
64
Anatomical features of the canine C2-C3 spinal cord vascular environment Taroni 2022
Interarcuate branch (IAB) is a vascular structure, particularly developed in C2-3 intervertebral space, forming a dorsal bridge that connects ventral venous plexi in the vertebral canal, forming a ventrodorsal triangle surrounding the spinal nerve root. when performing a laminectomy or hemilaminectomy, precise knowledge of those vascular structures is critical to prevent hemorrhage
65
Ex vivo study of the intradiskal pressure in the C6-7 intervertebral disk after experimental destabilization and distraction-fusion of the C5-C6 vertebrae in canine cadaveric specimens Knell 2021 | AVJR
On the basis of the results of the present study, we concluded that distraction-fusion of the C5-C6 vertebrae did not alter the IDP in the C6-7 (caudally adjacent) IVD in ex vivo cadaveric canine C4-T1 vertebral specimens without evidence of IVD degeneration. Although the limitations of this study precluded us from drawing any definitive conclusions regarding the complex pathogenesis of ASDis, IDP does not appear to play a major role in the early phase of the disease process while the IVD has no degenerative changes. Because degeneration alters the ability of nucleus pulposus to absorb forces, it is possible that the IDP in IVDs adjacent to vertebral distraction-fusion sites may increase in vivo as disk degeneration progresses.
66
Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats Crawford 2018
incidence IVDD in cats 0.12 to 0.24%, compared with 2% in dogs Hansen type I disc disease and protrusions (Hansen type II Methods retrospective case series n=3 Results A routine ventral slot surgery without complication, neurological improvement in all Clinical Significance Ventral slot surgery good long-term outcome in for feline cervical intervertebral disc herniation. To avoid excessively wide slot > careful surgical planning was performed with preoperative measurement of the desired maximum slot dimensions
67
Cherrone 2004. A retrospective comparison of cervical intervertebral disk disease in nonchondrodystrophic large dogs versus small dogs. Rossmeisl 2013 Acute adverse events associated with ventral slot decompression in 546 dogs with cervical
68
Accuracy of a patient-specific 3D printed drill guide for placement of cervical transpedicular screws Sinead E. Hamilton-Bennet
Prospective case-series. Sample Population: Thirty-two cervical pedicle screws (CPS) placed in 3 large breed dogs. The majority (29/32) of these screws were placed without evidence of vertebral canal breach (grade 0), whereas a vertebral canal breach <2 mm (grade 1) was detected in 3/32 screws. In a cadaveric study comparing the biomechanics of bicortical pins and monocortical screws with PMMA placed free-hand in the canine cervical vertebral column, 100% of bicortical pins violated the vertebral canal compared with a much lower incidence after monocortical screw fixation.32 The angles for ideal screw insertion are of limited use in dogs, because of conflicting reports, inter- and intra-breed anatomical variations, and rotational effects of both surgical positioning and intraoperative probing or screwing on vertebral alignment.14,33,34 Consequently, free-hand CPS placement in dogs is not recommended.14,33
69
Non-ambulatory dogs with cervical intervertebral disc herniation: single versus multiple ventral slot decompression **Guo 2020**
Non-ambulatory: single 123 versus multiple 62 ventral slot Retrospective After surgery, 96.2% of the dogs reached ambulatory status. 36.8% residual neuro deficits time to recovery of ambulation and presence of residual neuro deficits not different between single vs multiple site ventral slot
70
Vertebral fixation does not affect recovery or recurrence of cervical intervertebral disc herniation in small dogs (< 15 kg) **Kikuchi 2023**
Vertebral fixation does not affect recovery or recurrence (< 15 kg) (n = 303) The recurrence rates were 4.7% (n = 7) in the VF group and 4.3% (6) in the nVF group. in small dogs with C-IVDH, even if the slot volume is increased to remove sufficient disc material during VSD, a good prognosis can be achieved with or without VF.
71
Video telescope operating monitor–assisted surgery is equivalent to conventional surgery in treatment of cervical intervertebral disc herniation in dogs ** Frankar 2023**
Video telescope operating monitor–assisted surgery 39 dogs V-slot Prospective study. No significant differences regarding the decompression, ventral slot width ratio, residual disc material, and sinus bleeding. No significant differences were found between the 2 groups regarding postoperative neurologic grade (P = .17).
72
Accuracy of a 3-dimensionally printed custom endoscopy port for minimally invasive ventral slot decompression in dogs: A cadaveric study Kang 2022
Cadaveric study. Animals: Fifteen Conclusion: Screw positioning and creation of ventral slots were accurately performed using the 3DEP by both inexperienced and experienced surgeons. Clinical significance: The use of a 3DEP for minimally invasive cervical ventral slot decompression may be an alternative to the conventional ventral slot in dogs. Additional studies are needed to evaluate efficacy and safety.
73
Recurrence of signs consistent with cervical intervertebral disc extrusion in dogs **Argent 2022**
rate of recurrent clinical signs following successful Sx or medical Tx of cervical IVDD. Retrospective. Recurrence = clinical signs or imaging complete initial recovery: medical 36/119 (30.3%), 83/119 (69.7%) - recurrence of clinical signs: 40/119 (34%) overall, 27/83 (33%) sx, 13/36 (36%) medical - imaging-confirmed recurrent extrusion: 24/40 (60%); 80% within 2 years of fx - medical most commonly same site - surgical most commonly adjacent disc - no difference in rate of recurrence with treatment types (small number of recurrences and lack of imaging confirmation)
74
Bach 2023 – effect of MRI-spinal cord compression ratio and initial neuro status on recovery after ventral slot | frontiers
no association between cord compression and neuro grade or recovery time caudal/cranial compression and recovery time - recovery: complete recovery at 10 days (77.2% overall) more likely with gr2 vs gr3 gr1,2,3 → faster recovery than gr4 - no significant difference in complete recovery rate at d30 - 77.2% by 10d, 15.8% (93% overall) complete recovery by 30d
75
Cervical intervertebral disc disease in 307 small-breed dogs (2000-2021): Breed-characteristic features and disc-associated vertebral instability T Aikawa 2024 | AVJ
distribution: 222/307 (72%) chondrodystrophic, 77/307 (25.1%) non-chondrodystrophic - disc-associated vertebral instability 45/307 (14.7%) - outcome: 295/307 (96.1%) recovery - associations: non-chondrodystrophic → older age, requirement for vertebral stabilization vertebral stabilization → male, caudal cervical site, non-chondrodystrophic - vertebral stabilization performed on the basis of apparent correction of mild compression on dynamic myelography
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Nessler 2018 – surgical vs conservative HNPE treatment
- 18/36 surgical, 18/36 conservative - site: C4-C5 most common, 3/36 T13-L1 - outcome: median time to ambulation: sx 6.6d (0-28d) vs conservative 5.9d (0-15d) - prognostic factors: intramedullary lesion length ratio on MRI associated with recovery - mortality 3/36 (8.3%) - 3/3 cardiac arrest – 2/3 immediate post-op - conservative tx no worse/better than sx - possibly due to liquid/gelatinous nature of HNPE
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What anatomical differences explain the predisposition of wobblers in large dogs | strutures involed: vertebra, disc, ligament
The vertebral height of the cranial aspect of the foramen in significantly smaller than small dogs, resulting in a funnel shaped vertebral foramen therefore cerase threshold of cumulative effects of structures encraoching on spinal cord | dober/g.dane have stenotic in caudal
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What three factors explain the pathophy of DACSM? | complex as many aspects unclear (doberman without CS)
**Vertebral canal stenosis = key static lesion** Pornounced torsion of the caudal cervical column leading to IVD degeneration (caudal cervical spine has three times more torsion than cranial) Protrusion of larger volume intervertebral discs **C6-C7, C5-C6 in 90%** leads to compression of spinal cord | middle age, large breeed
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What causes osseous compression in CSM?
causing severe formaen stenosis dt joint OA and : Proliferation of the laminae dorsally Articular processes dorsolaterally Pedicles laterally +/- disc, lig.flavem hypertrophy **c4-c7 in 80%** | young, giant breed
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What molecular mechanisms play a role in CSM?
**Apoptosis of oligodendrocytes** interfering with remyelination Significant reduction in monocyte chemoattractant protein/chemokine ligand 2 (MCP-1/CCL2) concentrations - Elevation of **IL6** - implicated in generation and propagation of chronic inflammation
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What are the rates of single lesions vs multiple lesions in CSM?
Large breeds: 50/50 Giant breeds: 20% single site, 80% multiple
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What is the rate of post-myelogram seizures in Dobermans?
25%
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dynamic vs instability
concept explains developemnt of CS based on experimental studies + proposed key mechanism in humans worsen or improve depending on position og vertebral column > cord more compressed with flexed or extnded > extension: 25% reduction of C4-7 diameter in dogs thus, combo of static and dynamic factors > no evidence that instability plays a role in most cases
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instability def
instability = loss of ability of vertebral column to maintain normal amounts of displacment under physioloical loads
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Dx CSM
rads: not confirm **CT** good bone resolution, rapid, sedation may miss main compression site or not ID mutple due to decreased contrast resolution invasive with myelogram more useful for OACSM **MRI** best access spinal cord pathology inc. accurtae predict site/severity/nature of compression (de caost 2006) cord atrophy = poorer prognosis tractography to assess for dynamic component (traction, flex/extend) *concept of dynamic lesions subjectove and assessment method have not be standadarised (da costa 2000)
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Vwf dz DCM
vwf helps platelt adhesion tp subendothelium, platelet aggregation and bind FVIII > deficiency reduced aggregation and primary haemostatic dz congenital or 3 types, tupe I most common in doberman where reduced [ ] of all multimers Dx: vwf antigen assay (eliza) sensitive + BMBT/genetic test Tx cryopreciptate w Vwf (effective within 30min, last 4hr)/FFp/desmopressin DCM: can be occult, therefore ECG + echo recommended
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What is the rate of improvement in conservative vs surgical treatment of CSM lack of concensus re best approahc, prob reflect limited understanding of dz mechanism and natural progression
Conservative: - 54% improved - 27% static Surgery - 81% improvement
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consrvative Tx
de costa: 20% worse vs 80% improve with sx 53% euthanised regardless if medical or sx non-diff in survival time (prob because slow progression) DACSM 1 yr MRI, OACSM 2yr MRI Tx: ex restrict/physio/nsaid or CCS
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How are corticosteroids helpful in conservative management of CSM?
Decrease vasogenic oedema Protection from glutamate toxicity Reduction of apoptosis
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Sx CSM > GOALs (8) decision made on severity/pain/compression/owner/other dz and fail medical many sx, reflects not one more superior than the other
- decompress and reduce recurrence - patient specific - consdier if >1 site - dynmic? - prosepctive studies to compare tehcniques > most literature based on surgeon preference - current evidence does not support instability as a factor - distraction-stabilise eliminate dynamic whch is prob presetn in all forms - pros/cons of surgery
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DACSM sx subjective if dynamic or static outcomes generally siimlar accross tehcniques disc: static (vslot) dymanic - D-S osseous: static (dorsal/hemi) +/- stabilise
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List the direct decompressive techniques for treatment of CSM
Ventral slot (72%) Inverted cone Dorsal laminectomy (79-95%, 30% recurrence) increase obidity Hemilaminectomy
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List the indirect decompression-distraction techniques for treatment of CSM
Pins and PMMA (73%) Screw Bar-PMMA PMMA plug (82%, long term 62%) Locking plate (73%) Distractible titanium cage polyetheretherketone (PEEK) cage with locking plates Traction screw with locking plates
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Direct decompression (4) single static ventral +/- dynmaic review short term uscess 80%, recurrenc2 20% difference between tehcnique outcomes??
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Indirect (6) all have problems goals = adeute distraction and maintian longterm wit osseous fusion most coomon complications = implant fail before fusion ideally use distractor rather than manual
**1. PMMA + Pins** single, increased failure if 2 v-slot then threaded positive profile pins, bone graft angles: 35 C5-6, 45 C7 monocoruical screw performed similar biomehcnically > reduced PMMA amount to reduce oeisiohageal irritation > modifications: corticcancellous bone to distract + u-shape wire spacer 71% sucess long term penetration risk 25-57% **6. disc arthroplasty** in humans no consensus aim to preserve all motion to reduce ASS (no fusion) probs: long-term lacking, high subsidence rate + still reduce IVD mobility
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What is a motion-preWhat is a motion-preserving technique for treating CSM? What are the benefits?serving technique for treating CSM? What are the benefits?
A technique to distract the spine while preserving moton - Allows direct decompression - Allows reestabishment of normal disc space with preserved motion to decrease risk of domino effect (adjacent segment disease) --
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What are some key points in the application of a PMMA plug? How can you reduce the rates of migration?
Discectomy, leaving approx 3-5mm of dorsal annulus intact Anchor holes in the adjacent vertebral end plates Bone graft into ventral disc space once PMMA has hardened A retention screw can help to prevent migration
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What complications are possible with CSM treatment? (8) | 15% complication rate
- Neuro deterioration (70% after continuous dorsal laminectomy, up to 42% with ventral techniques) - Improper implant placement (25-57%) > check with CT - Domino effect (20%) da costa 2007 with distract-stable - laminectomy membrane - Implant failure (7.5-30%) - Collapse of IVD - Insufficient decompression 6/7 dobberman on PM - - **Recurrence 24%** (jeffery 2001) - mortality 0-6%
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What MRI findins are associated with a poorer outcome for CSM?
Spinal cord hyperintensity on T2W with concurrent hypointensity on T1W images
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CSM **prognosis** Post-op: cage/analgesia/ice restrict exercise 2-3 months physio non-ambul (nursing/ucath/turn)
70-90% improve despite technique chosen in short term medical success in 50% no other factors affect outcome: duration, non-ambl Sx may not alter longterm outcome, though does appear to consistently improve outcome MST 36mth (de costa) if med or sx - prob due to progressive nature of the dz despite Tx (therefore deterioeation not necessarily due to sx fail) *more studies required on long-term, with increased power and more objective caution interpreting results of any Tx
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What are extradural synovial cysts?
Cysts originating from the zygapophyseal joints of the vertebral articulations and are located extradurally. Divided histologically into - synovial cysts (epithelial lining) - ganglion cysts (mucinous degeneration or articular cartilage)
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What is the main predisposing factor of extradural synovial cysts?
Degenerative changes of the zygapophyseal joint
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What are the treatment options for extradural synovial cysts?
Dorsal laminectomy Hemilaminectomy Percutaneous cyst rupture with corticosteroid injection (humans) Must remove enture cyst and periarticular soft tissues to minimize risk of recurrence
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CS cysts
Thoracolumbar synovial cysts: These cysts are seen in middle-aged and older large-breed dogs and usually cause unilateral spinal cord compression. caudal lumbar vertebral column/lumbosacral synovial cysts: Affected dogs are typically large-breed, middle-aged or older dogs, although lumbar cysts have also been reported in a 2-year-old Boxer.87,231 Clinical signs include pelvic limb lameness or weakness
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cyst Dx how look on MRI?
A presumptive diagnosis of extradural synovial cysts can be achieved via imaging, with MRI being the imaging modality of choice. well-circumscribed extradural mass(es) on one or both sides of the vertebral foramen. hyperintense in T2W hypointensity, isointensity, or hyperintensity in T1W (depending on cyst contents)
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CSM: traction resposnive what did da costa study say? 3 problems? | dynamic
compression that improves with with traction usually due to releif of compresion by AP or ligament, therefore inctease dural tube diameter expect to benefit from distraction-stabilisation sx de costa: MRI suggest that almost any compression whether static or dynamic will improve with traction >not based on evidence-based criteria >traction not standardised >cocept highly subjective according to current literature
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Surgical management and long-term outcome of dogs with cervical spondylomyelopathy with an anchored intervertebral titanium device **King 2020** 50% subsidence | 90% initially, but then 70% longer term, with 2 euthed
10 dogs with (DACSM) and 1 dog with osseous-associated Design Retrospective case series. myelography with or without advanced imaging , Sx with C-LOX implant. Long-term follow-up was available in 8/11 with owner questionnaire. 2 euth. Seven (70%) dogs with DACSM improved neurologically but had persistent neurological dysfunction Postoperative radiographs revealed cage subsidence in 5 (50%) dogs, and loosening of a single cranial or caudal vertebral body screw in 4 (40%) dogs with DACSM. Five major complications occurred in 4 (40%) patients Adjacent segment disease occurred in three dogs (30%) with DACSM conclusion: comparable to previously described distraction–stabilisation techniques.
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Association of neurologic signs with high-field MRI findings in 100 dogs with osseous-associated cervical spondylomyelopathy Marília de Albuquerque Bonelli 2021 prospective study found durastion/worsneing over 1.9 months > not confirmed in this study | retrosepctive study
100 dogs with OACSM and MRI more than one site (78%) and foraminal stenosis (91%). Dogs with multiples sites > more likely to have severe spinal cord compression There was correlation (weak) between neurologic grade and severity of spinal cord compression disc degeneration in 80% extradural intraspinal cysts (25%) majority of dogs with severe imaging signs were < 3 years of age. > older dogs not have more severe imaging changes or clinical signs
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Comparison of Cervical Stabilization with Transpedicular Pins and Polymethylmethacrylate versus Transvertebral Body Polyaxial Screws with or without an Interbody Distractor in Dogs Marinho 2022
transpedicular pin+PMMA vs transvertebral body polyaxial screw for cervical stabilisation, ex vivo - no significant difference in angular range of motion at C6-C7 between groups - significantly reduced vs intact spine regardless of method - no significant increase in ROM of adjacent vertebrae
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Instrumented cervical fusion in nine dogs with caudal cervical spondylomyelopathy Bok 2019 [
instrumented cervical fusion for DA-CSM. MST 27 months. - titanium cage (SynCage-C) with 2x ventral locking plate augmentation - pain scores improved 9/9, neuro score 8/9 at median 27.4m (9-51) - bone ingrowth 79.5±14.3% → spinal fusion in 9/9 - complications: subsidence 1/9, 4/9 implant failure → 2/9 plate removal - adjacent segment pathology: 7/9 dogs Dogs have a natural lordotic position that increases the risk of ventral extrusion of intervertebral implants from shearing forces
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Short-Term Clinical and Radiographical Outcome after Application of Anchored Intervertebral Spacers in Dogs with Disc-Associated Cervical Spondylomyelopathy Rohner 2019
neuro improvement: 18/37 immediate post-op, 28/37 at 6w, 25/25 at 3m (19/25 normal) - complications: 22/25 screw loosening/breakage, 15/25 subsidence, 4/25 revision - 3/37 mortality – gastric perf, cervical disc-extrusion, progressive cervical pain Clinical Significance short-term clinical improvement in 33/37 treated cases. The high incidence of screw loosening > new locking system was required. The C-LOX device seems to be a valuable alternative The absence of a control group > impossible to directly compare the C-LOX implant to other existing distraction–fusion techniques
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Jeffery and colleagues found an 80% short-term success of DA-CSM surgery in their meta-analysis, butapproximately 20%recurrence inlong-termfollow-up.15,29
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Ultrasound-guided paravertebral perineural glucocorticoid injection for signs of refractory cervical pain associated with foraminal intervertebral disk protrusion in four dogs Wolf 2021
1mg/kg injections - successful in 3 of 4 dogs. Dog which was unsuccessful was unclear if disc protrusion was the cause of the lameness. Successful cases required 2-3 injections prior to long term resolution of signs
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Biomechanical effects of a titanium intervertebral cage as a stand-alone device, and in combination with locking plates in the canine caudal cervical spine Rick Beishuizen
ex vivo biomechanical properties titanium intervertebral cage +/- plates - placement of cage: increased disc height index vs post-discectomy restoration of ROM in flexion/extension, lateral bending, rotation restoration of elastic zone stiffness in flexion/extension - addition of plates → reduction of total ROM in flexion/extension, lateral bendingmore research is necessary Need more study on long term, the risk of cage migration, non-union and subsidence and bony ingrowth through the cage.
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Cervical Distraction-Stabilization Using an Intervertebral Spacer Screw and String-of Pearl (SOP™) Plates in 16 Dogs With Disc-Associated Wobbler Syndrome **Solano 2015**
Application of the FITS device in combination with 2 ventral SOP™ locking plates and autogenous cancellous bone graft was associated with excellent outcomes in dogs treated for DAWS in this small case series Fifteen of the 16 dogs had significantly improved neurologic status (P =.01) at 6 weeks. Seven of the 16 dogs were examined at 24-36 months with 6 considered normal and 1 had mild ataxia. Postoperative radiographic intervertebral distraction was significant (P = .01). Radiographic bridging was recorded in 10/16 dogs at 6 weeks and in 7 dogs available for follow-up at 5-36 months. Computed tomography in 3 dogs at 24-36 months and postmortem with histology in 1 dog confirmed bone-bridging. Complications were not considered clinically significant and included implant loosening (2 dogs, both single plates) and minor end-plate subsidence (8 dogs).
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Bonelli 2021 – association between neuro signs and DA-CSM - 51/63 (81%) foraminal stenosis, 40/63 (63%) T2W-hyperintensity, 24/63 (38%) ligamentum flavum hypertrophy – most >6y old 55/63 (88%) articular process degeneration – correlated with IVD degeneration - neuro severity moderately correlated with spinal cord compression | BMC vet
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Kinematics of a Novel Canine Cervical Fusion System Zindl 2021
kinematics of Fitzateur canine cervical-fusion system - combination locking pedicle screw-rod system + intervertebral spacer (traction screw) - intervertebral spacer increases stiffness of construct - Hettlich 2014 (with PMMA); Schollhorn 2013 (with locking plates) Fransson 2007 (intervertebral plug) - implant → significantly reduced motion at implanted site - concomitant (non-significant) increase at adjacent site (C6-C7)
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Joffe 2019 – custom interbody fusion device for DA-CSM - 3D-printed titanium alloy + ventral plates - progressive fusion in 2/2 dogs by 6 months - 2/2 clinical improvement; 1/2 no subsidence, 1/2 mild subsidence