Ch 88 Salivary glands Flashcards

(45 cards)

1
Q

four major salivary glands

A

parotid, mandibular, sublingual, and zygomatic

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2
Q

Parotid Gland

A
  • positioned superficial to the vertical ear canal, rostrally by the masseter muscle and TMJ, caudally by the sternomastoideus and cleidocervicalis muscles, ventrally by the mandibular salivary gland
  • deeper surrounding structures, including, but not limited to, the facial nerve, maxillary and temporal arteries, internal maxillary vein
  • duct: travels over the lateral aspect and ventral third of the masseter muscle and opens into the oral cavity at PM4
  • arterial supply: parotid artery, a branch of the external carotid artery
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3
Q

Zygomatic Gland

A
  • ventral and rostrolateral to the globe and medial to the zygomatic arch
  • One major and up to four minor salivary ducts
  • major duct opens at last upper molar
  • supplied by a branch of the infraorbital artery
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4
Q

Mandibular and Sublingual Salivary Gland

A
  • intimately associated and thus considered anatomically as a pair.
  • two glands have a common capsule
  • mandibular gland lies on medial aspect of the linguofacial and maxillary vein junction, mandibular lymph nodes ventral surface and the medial retropharyngeal lymph node and larynx on its medial surface
  • duct: exits into the oral cavity at the sublingual caruncle
  • major blood supply: branch of the facial artery
  • sublingual salivary gland is composed of monostomatic and polystomatic portions.
  • polystomatic salivary tissue consists of small clusters of glandular tissue rostral to the lingual nerve that typically empty directly into the oral cavity.
  • duct courses alongside the mandibular duct and usually exits at the sublingual caruncle
  • blood supply: glandular branch of the facial artery and sublingual branch of the lingual artery
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5
Q

Minor Salivary Glands

A
  • buccal, labial, lingual, tonsillar, palatine, and molar
  • molar gland is well developed in cats and is located just deep to the buccal mucosa at the angle of the mandible.
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6
Q

List the functions of saliva

A

Lubricate ingesta

Facilitates making a food bolus

THermoregulation

Cleansing

Buffering

Reduction of bacterial growth

Protection of oral surface epithelium

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7
Q

Describe the two phases of saliva production

A

Phase 1: Acinar cells absorb Na which draws water in, producing Na-rich saliva

Phase 2: Saliva enters the collecting ducts. Active reabsorption of Na with secretion of HCO and K. Occurs mainly in intralobular duct. Forms saliva rich in bicarb and K

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8
Q

WHat structures are closely associated with the parotid salivary gland?

A

Facial nerve
Maxillary and temporal arteries
Internal maxillary vein
Regions surround external acoustic meatus and stylomastoid formen

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9
Q

Where so the parotid and zygomatic salivary glands enter the oral cavity?

A

Parotid: Small papilla at the level of the upper 4th premolar
Zygomatic: Caudolateral aspect of last upper molar

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10
Q

What is the anatomical delineartion between the monostomatic and polystomatic portions of the sublingual salivary gland?

A

the lingual nerve
- Caudal is monostomatic
- Rostral is polystomatic

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11
Q

Secretions from what glands have a higher proportion of mucus?

A

Sublingual and zygomatic

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12
Q

What causes the stimulation of saliva production?

A

Autonomic nervous system
- Stimulation of parasympathetic nervous system stimulated the production of salvia by vasodilation of blood supply and by stimulation of cyclic guanosine monophosphate (cGMP) which directly upregulates the acinar cells

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13
Q

What is sialadenosis?

A

Non-inflammatory, non-neoplastic bilateral swelling of the salivary glands. Most common mandibular glands

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14
Q

What is the treatment for sialadenosis?

A

Phenobarbital 1-2mg/kg PO BID.

Clinical signs should improve within 1-2 days. This response may support a diagnosis of limbic epilepsy (cause of sialadenosis is unknown)

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15
Q

List 2 proposed caused of noninfectious sialadenitis / necrotising sialometaplasia

A

Hyperstimulation of the vagus nerve, resulting in a neural reflex syndrome similar of hypertrophic osteopathy. Can have concurrent oesophageal or GI disease

Limbic epilepsy - response to phenobarbital reported

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16
Q

How can you differentiate sialadenitis from sialadenosis?

What breeds are predisposed to sialadenitis?

A

Sialadenitis will cause pain upon palpation of effected glands and vomiting
Terrier breeds are predisposed to sialadenitis

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17
Q

What breeds are predisposed to sialocoeles?

A

Poodles, GSD, Australian Silkies and Dachshunds

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18
Q

four main presentations are:

A
  • exophthalmos (zygomatic sialocele)
  • labored breathing (pharyngeal sialocele)
  • dysphagia (sublingual sialocele or ranula)
  • intermandibular or cranioventral cervical swelling (cervical sialocele)
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19
Q

diagnosis

A
  • fluid-filled mass that contains a viscous, honey-colored, clear or blood-tinged fluid
  • Cytological: moderate numbers of nondegenerate nucleated cells, homogenous pink- to violet-staining mucin, foamy Macrophages
20
Q

Zygomatic Sialoceles

A
  • exophthalmos, protrusion of the third eyelid, or a painless orbital swelling
  • sialography, cross-sectional imaging

Tx: sialadenectomy or Use of a sclerosing agent

21
Q

Pharyngeal Sialoceles

A
  • caudal dorsal or lateral pharynx, just rostral to the level of the epiglottis
  • Miniature Poodles and male overrepresented
  • concurrent ipsilateral cervical sialoceles in 43% of affected dogs
  • Pharyngeal sialoceles pose a risk for airway obstruction

tx: Immediate drainage or temporary tracheostomy if respiratory distress, marsupialisation and removal of mandibular and sublingual gland-duct complex

22
Q

Sublingual Sialoceles

A
  • Sublingual sialoceles, also called ranulas, likely result from leakage of the rostral sublingual salivary glands or duct
  • esulting in difficulty with eating
  • ranula should be drained and marsupialized into the oral cavity. Incomplete removal of the sublingual salivary chain can result in recurrence
23
Q

Cervical Sialocele

A
  • fluctuant in nature, nonpainful, and occasionally changes in size, Diagnosis is made primarily by aspirating
  • mucin-specific stain, such as periodic acid–Schiff, help to confirm saliva
  • radiographs, sialography, CT, MRI, ultrasonography, culture, and biopsy
  • ddx branchial cleft cyst can be differentiated from a sialocele > demonstration of a true secretory lining on histo
  • most cervical sialoceles originate from the sublingual gland-duct complex
  • determining side: chronic, placed in dorsal recumbency > fluid accumulation usually displaces laterally to the affected side.
  • may require sialography, CT, MRI, or an exploratory surgery
  • If any question remains, bilateral sialadenectomy can be performed (dry mouth is not expected)
  • Conservative treatment of sialoceles > high rate of recurrence
24
Q

What is the reported rate of recurrence of sialocoele after surgical removal of the gland?

A

5%

complications: seroma, infection, recurrence, sublingual swell, bleeding

25
Where do sialoliths most commonly occur? | demonstrate a swelling on the lateral aspect of the face
Parotid duct | composition: calcium oxalate, phosphate, magnesium, or nonmineral
26
List the possible treatments of sialoliths
Surgical removal of effected duct-gland complex Incision through oral mucosa directly over stone Resection and anastomosis of duct Marsupialisation of dilated duct
27
What glands are most commonly effects by neoplasia? What are the most commonly reported neoplasms? (All are rare) What is the reported rate of LN involvement?
Mandibular and parotid glands most commonly effected Adenocarcinoma and acinic carcinoma most common LN involvement in 17% dogs and 39% cats
28
salivary gland neoplasia
- staging recommended > prognosis is not correlated with histologic grade but is associated with stage of disease - owner to understand whether the procedure is being performed for diagnosis, cytoreduction, palliation, curative intent, prevention, or metastasectomy - Sentinel lymph node extirpation can be performed - prognosis is largely unknown
29
Sublingual and Mandibular Sialadenectomy
- ventral approach permits removal of the entire sublingual gland-duct complex compared to lateral Ventral Approach - platysma muscle is incised to facilitate identification of the external jugular bifurcation; the mandibular gland sits at or just cranial to this bifurcation - The capsule over both glands is incised and bluntly dissected, vessels on the medial side ligated - The gland complex retracted caudally to allow blunt dissection of the sublingual gland under the digastricus muscle. - hemostat placed from rostral to caudal under the digastricus muscle, the glands are excised - remaining ducts and sublingual glands are pulled under the digastricus muscle, dissection are continued to the level of the lingual nerve (the mylohyoideus muscle is incised for best exposure) - If a ranula is present, however, dissection should continue rostral to the lingual nerve under the mylohyoideus to the sublingual caruncle - incisional drainage of the sialocoele with or without drain placement
30
Zygomatic Sialadenectomy
- aponeurosis of the masseter muscle is reflected off of the ventral aspect of the zygomatic arch, and the orbital fascia is reflected dorsally. - portion of the arch is removed, as necessary, with a bone saw - Orbital fat is dissected and retracted - gland resides medial to the zygomatic arch and adjacent to the globe -
31
Parotid Sialadenectomy
- facial nerve paresis or paralysis is a common complication. - starting at a point below the external acoustic meatus and extending ventrally - platysma and parotidoauricularis muscles are incised - ligation and division of the caudal auricular vein, the parotid gland is bluntly dissected -
32
conservative mgmt options
1. Intralesional injections of sclerosing agents (polidocanol) successfully used for orbital mucocele 2. radiation therapy 3. N-acetylcysteine (gland preserving) 4. medical antibiotics and nsaid
33
What additional step during parotid sialadenectomy should be performed if the patient presented with lateral cheek swelling?
Dissection and removal of accessory parotid gland just dorsal to the parotid duct
34
Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: A multi-institutional, retrospective, Veterinary Society of Surgical Oncology study Bush 2023
Retrospective. 72. surgically excised canine salivary gland carcinoma The overall (MST) was 1886 days. recurrence (42%), overall (DFI) of 191 days. Metastatic disease occurred in (31.9%) dogs node metastasis present (28.9%) dogs > lymphadenectomy; these dogs had a shorter MST at 248 days Nodal metastasis was a negative prognostic factor Thirty-four dogs received adjuvant therapy following surgery. Chemotherapy, radiation or nonsteroidal antiinflammatory The perioperative complication rate was 23.6%: facial nerve injury 10% and swelling or seroma formation
35
Intraoral approach for zygomatic sialoadenectomy in dogs: An anatomical study and three clinical cases Viitanen 2023
Intraoral approach for zygomatic sialoadenectomy. Cadaver and 3 cases. compare this surgical approach to a modified lateral orbitotomy Removal of the ZSG was complete in 8/10 and 10/10 dogs using the IOA and LOA, respectively case series had no complications. salivary duct catheterised and injected with methylene blue. IOA: reduced surgical time, no preoperative clipping was necessary and less tissue dissection was needed. minimizing invasiveness of the approach. Need to compare different techniques clinically.
36
The use of methylene blue to assist with parotid sialadenectomy in dogs I. Gordo 2020
Methylene blue was either administered via cannulation of the parotid duct or directly injected into the abnormal gland. R esults: In all cases, the gland stained dark blue within seconds without any evident leakage. Complete parotid gland resection and removal of the parotid duct was achieved successfully in all dogs Subjectively, the staining was useful to identify innervation outside the coloured gland and facilitated dissection
37
Tumor size as a predictor of lymphatic invasion in oral melanomas of dogs Carrol 2020 | kuntz
59 samples of oral melanomas significant relationship was identified between the size of oral melanomas and a single variable of histologic grade, lymphatic invasion, lymphatic invasion can confidently be ruled out for tumors < 0.65 cm in diameter (100% sensitivity) and ruled in for tumors ≥ 2.45 cm in diameter (100% specificity). Lymphatic invasion has been described as the gold standard for identification of malignancy invasion is negatively associated with patient survival in dogs with oral melanomas. Of the 52 melanomas investigated, a significant (P = 0.014) difference was observed in the MST of dogs with (7.3 months) and without (10.5 months) lymphatic invasion.
38
Nasopharyngeal sialoceles in 11 brachycephalic dogs Davide De Lorenzi | 2018
may cause obstruction of airway Surgical deroofing of the sialoceles was performed under endoscopic guidance with biopsy forceps in 5 cases and by diode laser in 6 cases. No recurrence was diagnosed chronic nonphysiologic mechanical stress causing changes in minor nasopharyngeal salivary glands. Direct visualization by nasopharyngoscopy is the best technique for detection of NPS,
39
Comparison of three surgical approaches for zygomatic sialoadenectomy in canine cadavers Dörner 2021 | 2021
Cadaveric. Comparison of three surgical approaches for zygomatic sialoadenectomy lateral + ostectomy vs without ostectomy + ventral or dorsal to the zygomatic arch. Ostectomy > excellent surgical view and good exposure with more tissue trauma. Dorsal nonostectomy > not allow complete gland extraction, relatively blind dissection ventral nonostectomy approach enabled complete extraction in all 10 dogs. zygomatic gland crossed by a branch of the deep facial vein.
40
Intracanalicular injection of N-acetylcysteine as adjunctive treatment for sialoceles in dogs: 25 cases (2000–2017) Ortillé 2020
retrospective (no control group) Intracanalicular injection of 10% N-acetylcysteine. 25 dogs. The zygomatic gland > [92%] dogs, most considered idiopathic performed with local anesthesia, + ab’s and NSAID recurrence [22%] dogs, all managed medically. N-acetylcysteine, a cysteine prodrug and glutathione precursor = mucolytic and antioxidant agent. Expect disruption of thick salivary secretions > aim to preserve function of gland (vs surgical removal) could have a role as a first therapeutic approach >, potentially reducing the need for surgical intervention
41
External beam radiotherapy for the treatment of feline salivary gland carcinoma: six new cases and a review of the literature Blackwood 2019
Five were treated after surgical excision of the primary tumour, but four had gross disease (primary or metastatic) at the time of starting radiotherapy. No cat died as a result of distant metastatic disease. Survival time was known for three cats (55 days, 258 days and 570 days 5 cats also recieved chemo RT side effects were very mild: all cats had VRTOG grade 1 toxicity at the end of therapy surgery and radiotherapy is superior to radiotherapy alone. However, the benefits of postoperative radiotherapy compared with surgery alone are only clear in patients with high-risk tumours (ie, those with large and invasive primary tumours, close or incomplete margins, high histopathological grade, histological evidence of neural or vascular invasion, or positive lymph nodes). This radiation therapy may help improve locoregional control and survival in cats
42
Outcomes of surgically treated sialoceles in 21 cats: A multi-institutional retrospective study (2010–2021) Marti 2024
Retrospective. surgically treated sialoceles in 21 cats dysphagia and ptyalism + rannula Surgical = sialoadenectomy and/or marsupialization (4 cats). Intraoperative complications 3 cats (mandibular lymph node inadvertently removed), postoperative 5 cats. resolution of clinical signs in all cats. No recurrence > follow-up period (30–968 days). sublingual and mandibular most commonly affected. post-op complications: 23.8% higher than canine retrospective studies (15%). swelling Over half of the cats in the current study had undergone previous drainage of the sialocele The aetiology: traumatic 2, neoplastic 1 and unknown in most
43
Feline minor salivary gland adenocarcinoma: retrospective case series and literature review Laureano 2023
caudal labial masses. Curative intent surgery was performed in three cats, whereas palliative surgery (debulking) owing to extensive soft tissue invasion was performed in one cat. Survival times were in the range of 210–1730 (mean 787) days. All four cats were euthanized owing to local recurrence and decreased quality of life, regardless of treatment modality. propose that early aggressive surgical treatment with wide surgical margins should be performed for cats with salivary gland adenocarcinoma of minor salivary gland origin. Surgery increased the quality and duration of life
44
Clinical findings, surgical treatment and outcome in dogs with parotid duct ectasia: 14 cases (2010-2023) Martinez 2024
Salivary duct ectasia, defined as dilation of the salivary duct, has been rarely reported in veterinary literature Fourteen dogs were included. Lateral facial swelling was the most common clinical presentation. CT revealed a tortuous cavitary tubular fluid-filled structure consistent Surgical treatment included marsupialisation of the parotid duct papilla, surgical exploration of the duct alone, parotid duct marsupialisation with surgical exploration of the duct, parotidectomy or en-bloc parotid duct resection No recurrence of clinical signs was noted during the follow-up period (range 21 to 2900 days The treatment method should be selected based on the location of the stricture and the extent of the ductal dilation. If the stricture is present near the parotid duct orifice or in the parotid duct near the oral cavity, reimplantation or marsupialisation represent two valid options (Baurmash, 2007; Han et al., 2020; Yoon et al., 2009). Whereas if the obstruction is near the parotid gland, parotidectomy or duct ligation are preferable In the authors’ opinion, parotidectomy should be reserved for animals where the aetiology or diagnostic imaging findings indicate that main lesion is in, or close to, the parotid gland, as it carries a high risk of facial or trigeminal nerve injury
45
Complications between ventral and lateral approach for mandibular and sublingual sialoadenectomy in dogs with sialocele Cinti 2021
- ventral and lateral approaches for mandibular/sublingual sialoadenectomy, n=140 complications: lateral 20%, ventral 31% - no difference in incidence; overall 24% - recurrence more likely after lateral approach and with prolonged sx - wound-related complications more likely after ventral approach