Ch 107 Pericardial surgery Flashcards

(36 cards)

1
Q

What are the 2 layers of the pericardium?

A

Outer fibrous layer
Inner serous layer (closed mesothelial lined sac with parietal and visceral layers)

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2
Q

anatomy

A
  • envelopes the heart; root of the aorta and pulmonary artery; and termination of the venae cavae, pulmonary veins, and azygos vein.
  • visceral layer of serous pericardium known as the epicardium.
  • The epicardium is attached firmly to the myocardium
  • caudoventral apex of fibrous pericardium anchors ventrally at the muscular insertion of the diaphragm (sternopericardiac ligament)
  • pericardium is supplied by paired pericardial branches of the internal thoracic arteries
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3
Q

List the functions of the pericardium

A
  • Keeps the heart in position
  • Restrains cardiac filling
  • Enhances diastolic ventricular couplig
  • Protects against atrial rupture
  • Prevent spread of infection or neoplasia to heart from pleural cavity
  • Provides a gliding surface for heart motion

pericardium is noncompliant and has a small reserve volume, intrapericardial pressure rises rapidly when the volume of its contents increases acutely.

With slow accumulation, the pericardium stretches

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4
Q

What does pericardial fluid contain?
What is a normal volume?

A

Pericardial fluid is an ultrafiltrate of the serum
- phospholipids for lubrication
- Protein 1.7-3.6g/dL
- Colloid osmotic pressure approx 25% of serum

Normal volume 1-15ml

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5
Q

What are the physiologic effects of cardiac tamponade? (7)

A
  • Decreased cardiac output
  • Increased central venous pressure
  • Activation of compensatory RAAS and sympathetic adrenomedullary catecholamine release
  • As atrial wall stretching is limited, atrial natriuretic peptide is not produced and therefore does not counteract effects of RAAS
  • Increase in systemic venous and portal pressures causing jugular vein distention, liver congenstion, ascites and peripheral oedema
  • Compression of coronary arteries causes poor myocardial perfusion
  • Cardiogenic shock and death
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6
Q

cardiac tomponade

A

Cardiac tamponade:
Increased pericardial pressure → increased diastolic pressure → reduced stroke volume
- pericardial pressure = right ventricular filling pressure (R-sided tamponade)
→ left ventricular filling pressure (L-sided tamponade)
→ decreased cardiac output, increased systemic venous pressure
→ activation of RAAS → Na+ and H2O retention
+ sympathetic stimulation/catecholamine release → +ve ino- + chronotropic effects and vasoconstriction
- no atrial wall stretch → no atrial natriuretic peptide → no counteracting RAAS effects
→ increased systemic venous and portal pressure
→ jugular vein distension, liver congestion, ascites, peripheral oedema
+ compression of coronary arteries → myocardial hypoxia/ischemia
+ decreased cardiac output and arterial hypotension → cardiogenic shock → death

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7
Q

What is pulsus paradoxus?

variations of pressure quality associated with respiration phase

A

A variation in systolic arterial pressures up to 10mmHg from increasing venous return during inspiration in a relatively nonexpandable heart (due to pericardial effusion) causing intraventricular septal shift to the left, reducing CO

Can also be seen with obstructive lung disease, restrictive cardiomyopathy or hypovolaemic shock and is therefore not pathognomonic for pericardial effusion

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8
Q

Pulsus paradoxus:

A

Paradoxical arterial pressure variation during severe cardiac tamponade
Inspiration → decreased pericardiacl pressure and right ventricular pressure
→ venous return to right atrium, ventricle and pulmonary flow
- heart volume limited by pericardium – left intraventricular septum shifts to left
→ decreased left ventricular EDV, left heart output and arterial pressure
→ variation in systolic arterial pressure

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9
Q

The Beck’s triad, a classic indicator of cardiac tamponade, consists of three main symptoms: hypotension (low blood pressure), jugular venous distension (JVD) or bulging neck veins, and muffled heart sounds

A
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10
Q

What is the risk associated with partial pericardial defects?

A

Cardiac herniation

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11
Q

What have pericardial cysts been associated with?

A

PPDH
Other cases have been on a stalk at the apex of the pericardium
Suggests they result from entrapment of omentum, falciform ligament or liver in pericardium during development

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12
Q

What 2 syndromes can be associated with pericardial rupture?

pathophys

A

During healing, a stricture can develop causing vena caval compression
- Budd Chiari Syndrome: ascites and hepatomegaly
- Caval syndrome: Swelling of head and neck

Caval angiography for diagnosis. RIght 5/6th IC thoracotomy for resection of fibrotic sac +/- angioplasty with pericardial patch graft

severe ascites

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13
Q

rupture Tx

A
  • caudal vena cava may appear to be kinked
  • Caval angiography for diagnosis.
  • RIght 5/6th IC thoracotomy for resection of fibrotic sac +/- angioplasty with pericardial patch graft
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14
Q

Pericardial Effusion
Etiology

A
  • transudative: congestive heart failure, peritoneopericardial diaphragmatic hernia, hypoalbuminemia, or increased vascular permeability
  • exudate: infectious or noninfectious pericarditis
  • hemorrhagic: trauma, neoplasia, anticoagulant intoxication, or rupture of the left atrium secondary to mitral valve disease, idiopathic
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15
Q

What are the most common neoplastic causes of pericardial effusion?

A

HSA of right atrial appendage
Chemodectoma, usually along ascending aorta (brachycephalics most common)
mesothlioma (difficult to distinguish from idiopathic)

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16
Q

What breed is overrepresented for pericardial effusion?

A

Golden retreiver

17
Q

What is an expected central venous pressure of a dog with pericardial effusion?

A
  • Classic findings: muffled heart sounds, weak femoral pulses, tachycardia, and distention of jugular and peripheral veins.
  • Chronic: CHF and acities
  • acute manifestation because of acute bleeding

With cardiac tamponade, central venous pressure frequently exceeds 10 to 12 mm Hg

18
Q

Describe the following ECG

A

Electrical alternans
- Amplitude of QRS and ST-T complexes changes from 1 complex to another due to heart swinging in fluid filled pericardial sac
- Strongly suggestive of pericardial effusion

19
Q

Pericardial Fluid Cytology and Analysis

A
  • usually do not differentiate the underlying cause
  • serosanguineous pericardial effusions are rapidly depleted of clotting factors, fluid samples will not clot in an activated clotting time tube unless active hemorrhage is present
  • cytology not reliable to dx neoplasia
20
Q

What is the sentivity and specificity of echocardiogram for cardiac mass detection?

Neither CT/MRI found to improve detection of cardiac masses.

A

82 and 100%

  • anechoic space between the epicardium and pericardial sac
  • Collapse of the right atrium or ventricle during diastole
  • allows visualization of cardiac masses or myocardial infiltration
21
Q

RADS

A
  • With chronic effusion and pericardial distention, the cardiac silhouette becomes globoid in shape
  • pleural effusion, which often accompanies pericardial effusion
22
Q

What can be measured in the plasma of dogs with pericardial effusion which is assoc with HSA?

A

Cardiac troponin I
- Conc over 0.25ng/ml 82% senstivite and 100% specific for cardiac HSA

23
Q

Where do you perform a pericardiocentesis?

ECG > touche myocardium, premature complex will occur

A

Right 5/6th ICS with a 20g needle/catheter

24
Q

pericardiocentesis - complications

A

adverse events in 10%:
- dysrhythmias,
- cardiopulmonary arrest
- continued bleeding

Blood vs effusion: effusate should not clot, and its PCV &laquo_space;peripheral blood

20 g needle, extension set, three-way stopcock, and large syringe.

25
What are the surgical options for pericardial effusion? (4)
Pericardiectomy - Subtotal or complete (complete does not improve outcomes) - through a median sternotomy or ICT Thoracoscopic pericardial window - 3x3cm window in large breed dogs (too large risk cardiac herniation) - Transdiaphragmatic (subxiphoid with right 4th and 7th ICS or right and left 7th ICS) or intercostal approach - biopsy masses Thoracoscopic subtotal pericardiectomy - Transdiaphragmatic approach with instrument cannulas in left and right 9th ICS Percutaneous Balloon Pericardiotomy
26
pericardectomy
- can be curative for idiopathic pericardial effusion and possibly palliative for neoplastic - decreases the surface area of pericardium, thus reducing fluid production - increases the surface area for absorption by allowing fluid into the pleural cavity
27
What is the prognosis for pericardial effusion? - neoplastic, idiopathc, pericardiocentesis, pleural effusion
Neoplastic: - HSA MST 16d - Aortic body tumours, MST 730d with Sx vs 42d - Mesothelioma usually deveolps unremitting pleural effusions 1.5-5m post pericardiectomy. MST 10.5-13.6m Idiopathic - Excellent - Subtotal pericardiectomy 100% surviva at 3yr (Dunning et al) - Another study 12% dies periop, 16% died within 1 yr, 72% long term survival - Pericardial window MST 13.1m, 35% survival at 3yr - MST 22m pericardiocentesis ONLY - outcome is variable - 9 of 14 dogs (one to three treatments), most alive follow-up 3 years late - palliative for HSA pleural effusion - most common complication undergoing pericardiectomy - if lasts > 30 days, more likely to have a poor prognosis
28
Constrictive Pericarditis
- Chronic inflammation of the pericardium results in extensive fibrous tissue proliferation and pericardial thickening. - Severe lesions can constrict the heart, which compromises cardiac filling and CO - caused by any condition that results in chronic pericarditis. pathophys - noncompliant pericardium abruptly limits ventricular filling and produces near equilibration of all cardiac chambers. As the condition worsens, cardiac output declines - RCHF from activation of the RAAS
29
What is the Kussmaul sign?
Paradoxical, persistent increase in jugular venous pressure during inspiration - Assoc with constrictive pericarditis - Negative intrathoracic pressure during inspiration is not transmitted to the cardial chambers
30
How is restrictive pericarditis diagnoses?
Cardiac catheterisation - Measurement of pulmonary capillary wedge, atrial and ventricular pressures - Increased and equilibration or near-equilibration of diastolic filling pressures in all chambers
31
What is the Tx and prognosis for constrictive pericarditis?
Subtotal pericardiectomy - Relieved clinical signs in 6/10 dogs - Prognosis more guarded if epicardium involved - required decortication - Prognosis poor if develops after treatment of pericardial effusion
32
The development of ventricular fibrillation as a complication of pericardiectomy in 16 dogs Raleigh 2022 | kuntz
Retrospective, ventricular fibrillation as a complication of pericardiectomy in 16 dogs thoracoscopy (12), ICT (3) and MS (1). Electrosurgical devices used in 15 of 16 dogs. VF appeared initiated during electrosurgical use in 8/15 dogs 14 /16 (87%) dogs died from intraoperative VF incidence of VF = 3% In most > fatal complication of pericardiectomy. Three dogs were successfully converted to a sinus rhythm mechanisms for electrosurgical induction of VF - high current during T wave > immediately induces VF - multiple pulses of lower current (over 1-5 s) to epicardial cells - very low current over 90-300 s > increase in heart rate.
33
Systematic review of the treatment options for pericardial effusions in dogs Logan M. Scheuermann 2021
Systematic review > pericardial effusions in dogs. Most case studies (68.2%) or retrospective case series (25.2%) = low level of evidence. variability of the outcomes > not sufficient evidence to recommend one treatment option over another. subtotal pericardiectomy > longer survival time and DFI than thoracoscopic window > quality of evidence low idiopathic pericarditis/pericardial effusion → long-term survival with pericardectomy - difference between subtotal and thoracoscopic window uncertain - complete examination at time of surgery of heart and pericardium > to try ensure rule out neoplasia as affects survival outcomes neoplastic pericardial effusion → no prolongation of MST or DFI after sx vs conservative (hemangiosarcoma or mesothelioma) - when cardiac mass was present – pericardiectomy resulted in less recurrence of CS - no difference between subtotal and thoracoscopic window - Medications Yunnan Baiyao, aminocaproic acid, and chemotherapies > no clear benefit
34
Outcomes of dogs with recurrent idiopathic pericardial effusion treated with a 3-port right-sided thoracoscopic subtotal pericardiectomy Kurt P. Michelotti 2019
Retrospective case series. Animals: Sixteen client-owned dogs. Thoracoscopic subtotal pericardiectomy can be readily performed with only 2 instrument ports, both on the same side of the dog, and without 1-lung ventilation. no surgical complications. The median duration of postoperative follow-up was 191.5 days (range, 5–1345). The median survival time (MST) after surgery was 365 days (range, 5–1345); MST of dogs with a histopathological diagnosis of neoplasia (n = 4) was 76 days, whereas dogs with no evidence of neoplasia had an MST of 367 days (n = 12, P = .14). Recurrent pleural effusion was the ultimate cause of death or reason for euthanasia in 8 of 16 dogs.
35
Outcome in dogs with presumptive idiopathic pericardial effusion after thoracoscopic pericardectomy and pericardioscopy Carvajal 2019
Multi-institutional retrospective study (2011-2017). Animals: Eighteen dogs Nine dogs had pericardioscopic abnormalities consistent with masses, nodules, or adhesions. Median survival time (MST) for the 9 dogs with abnormalities identified by pericardioscopy was 66 days, whereas MST for the 9 dogs with unremarkable pericardioscopic examination results was not reached (P = .0067). Median survival time for dogs based on histopathologic diagnosis alone was not different between dogs with a diagnosis of neoplasia and dogs with a diagnosis of pericarditis Thoracoscopic pericardectomy/pericardioscopy and targeted biopsy of the pericardium and pleura are recommended in dogs with echocardio graphic idiopathic pericardial effusion
36
Epicardial exposure provided by a novel thoracoscopic pericardectomy technique compared to standard pericardial window Laura A. Barbur 2018
describe a novel technique for thoracoscopic pericardectomy using a pericardial window with vertical pericardial fillets (PW1F). (2) To compare epicardial exposure between a standard pericardial window (PW) and PW1F.