Ch 92 small intestine Flashcards
(93 cards)
A carnivores SI is approx how long?
Approx 5 times the length of its trunk
1 - 1.5m in cats
2 - 5m in dogs
Anatomy
- duodenum along the right side of the abdomen (contains intrasmural bile duct, major and minor duodenal papillae)
- caudal duodenal flexure > triangular attachment of the initial part of the ascending duodenum is called the duodenocolic ligament
- left of the root of the mesentery duodenojejunal flexure
- mesojejunoileum is more commonly known as the mesentery > short peritoneal attachment known as the root of the mesentery
- root of the mesentery includes the cranial mesenteric artery, intestinal lymphatics, and large mesenteric plexus of nerves
- Nearly all of the intestinal blood supply is supplied through the cranial mesenteric artery, anastamoses with celiac and caudal mesenteric
- cranial mesenteric vein arborizes in the mesentery and collects blood from the jejunum, ileum, and caudal duodenum before terminating in the distal portal vein. The gastroduodenal vein drains the proximal duodenum
- nerve fibers to the mesenteric portion of the small intestine come from the vagus and splanchnic nerves
- ranial mesenteric ganglion is located on the sides and caudal surface of the cranial mesenteric artery
- clustered around the root of the mesentery are five or six large mesenteric lymph nodes
Where does the root of the mesentery attach?
L2
Within which layers of the SI does the vascular network run?
Beneath the serosa and within the submucosa
small intestine is structurally composed of four layers:
the mucosa,
- villi that increase the surface area approximately 8-fold in dogs and up to 15-fold in cats
- surface cells are of two types: columnar cells = absorption, and goblet cells = mucus-producing
- lymphoid follicles are grouped together to form aggregated follicles known as Peyer’s patches.
submucosa
- supporting skeleton of the gut
- Small blood vessels, lymphatics, and the submucosal nerve plexus
muscularis
- outer longitudinal layer and a thicker inner circular layer
serosa
- composed of the peritoneum
How often does the inner intestinal lining (villus epithelium) completely replace itself?
every 2-6 days
What are the 2 types of contraction seen in the small intestine?
Segmental contraction - Mixes ingesta
Peristaltic contraction - Moves ingesta aborally
local and vagally mediated (parasympathetic nervous system regulates)
What percentage of the water presented to is does the jejunum and ileum absorb?
Jejunum - 50% of presented water absorbed
Ileum - 75% of presented water absorbed
How do glucose and galactose enter the enterocyte?
Fructose?
Taken up by cotransport with Na via the transporter GLUT1
Fructose via GLUT2
physiology
- most water-soluble compounds such as amino acids and monosaccharides require membrane carriers to allow absorption through the intestinal mucosa.
- Cells at the base of the villus are dividing, undifferentiated epithelial cells (fluid secretion)
- differentiate into immature enterocytes as they pass up the crypt
- tip of the villus, lose secretory capacity > digestion and absorption.
- Absorption of sodium: passively across the jejunum or coupled with Na+-K+/ATPase–mediated active transport of monosaccharides or amino acids
- Digestion is achieved using a combination of enzymes from the small intestinal luminal brush border cells and the pancreas (trypsin, amylase, lipase) and, for fat digestion, bile released from the gallbladder
What electrolyte derangements are common with GI obstruction?
Hypochloraemia, Hyponatraemia and Hypokalaemia
- metabolic acidosis common
- Vomiting > excessive loss of gastric fluids rich in potassium, sodium, and hydrochloric acid,
- resulting in a hypochloremic, hypokalemic metabolic alkalosis
Fluid Therapy
- nimals with gastrointestinal disease often present with preexisting imbalances that must be corrected before surgery
- Preoperative treatment of hypovolemia resulting from intestinal obstruction or ileus consists of intravenous infusion of balanced electrolyte solutions and correction of severe acid-base and electrolyte abnormalities
- Surgical fluid losses occur from tissue damage during dissection and from evaporative losses, which are significant during intraabdominal surgical procedures
Fluid and electrolyte needs should be reassessed frequently after surgery.
Antibiotic Prophylaxis
- normally contains Gram-positive and Gram-negative organisms.
- antibiotic should be appropriate for the bacteria at surgical site (i.e., the proximal versus distal small intestines).
- in the tissues at the time of surgery
- first-generation cephalosporins remain one of the most effective
surgical approach
- midline
- laparoscopic-assisted: ventral midline subumbilical trocar cannula using a modified Hassan technique or a single-port device, bowle is exteriorised through skin (certain bowel segments (proximal duodenum, duodenal flexure) have limited mobility and cannot be adequately exteriorized)
How can fluoroscein be used for assessing SI viability?
Give 10-15mg/kg IV - results in wide distribution within minutes and full urinary excretion 24-36hr. Using a Woods lamp in darkened surgical suite, patchy areas with non-fluorescence >3mm indicates loss of vascularity
Assessment of Intestinal Viability
- many clinical criteria can either overestimate or underestimate
- presence of peristalsis, vascular pulsations, and intestinal color do not necessarily correlate with the histologic severity
- objective measurements of viability, such as surface oximetry or fluorescein infusion
Choice of Suture Material for Enteric Closure
- Monofilament synthetic absorbable (polydioxanone, polyglyconate) or nonabsorbable (nylon or polypropylene) sutures and staples are excellent choices
- Monofilaments are less susceptible to bacterial adhesion and allow easier clearance of bacteria by host defense mechanisms compared to mutifilament
- Absorbable knotless barbed suture
- inflammation at an incision site prolong the lag phase of wound healing and delay return of strength (all material do this to some degree)
What suture pattern can correct mucosal eversion when closing the GIT?
Modified Gambee pattern - Must be able to properly identify the submucosal layer for this pattern to be appropriate
Choice of Suture Pattern for Enteric Closure
- good submucosal apposition can result in primary intestinal healing with direct bridging of the defect.
- Submucosal apposition is poorer with two-layer closure than single-layer closure
- Two-layer closures also result in avascular necrosis of the inverted cuff of tissue (prolongs the lag phase of wound healing) and increased intraluminal protrusion (prone to obstruction)
- everting patterns are more likely to elicit adhesion formation.
- Approximating suture patterns: histologically in 66% of simple interrupted closures, and inversion, eversion, or misalignment of tissues is seen in 38% of simple continuous closures
- Simple interrupted, simple continuous, and modified Gambee
- full-thickness 3 to 5 mm from the tissue edge and 3 to 5 mm apart, with extraluminal knots
- STUDY: comparing simple interrupted and continuous patterns found a low and comparable rate of enteric leakage with either pattern
- surgeon’s knot provides excellent grip and security, particularly when using the slippery monofilament materials recommended for intestinal surgery
- too loose healing by second intention, too tight/crushing inhibits angiogenesis and impedes healing as well.
Suture Line Reinforcement
- omentum
- omentum sutured in placed around an anastomosis is more likely to prevent leakage than chance contact
- forms an adherent sheath that is capable of preventing perforation and fatal leakage and of revascularizing the region - serosal
- jejunal serosal patch has been called the surgical parachute
- shown, experimentally and clinically, to reliably seal contaminated and grossly infected intestinal perforations in dog
- sustained significantly higher intraluminal pressures before leakage,
- use of a serosal patch did not influence the rate of continued peritonitis or death
- Gallbladder serosal patch for defects in the proximal duodenum has shown promise in experimental studies
What are the properties of omentum which make it good for reinforcing your suture line?
Omentum has an extensive vascular and lymohatic supply and exhibits angiogenic, immunogenic and adhesive properties
What has been shown as the length of bowel and volume of saline to use for a leak test to simulate peristaltic pressure in small-medium dogs with digital occlusion? With Doyens?
- 10cm segment of bowel
- 16-19ml saline with digital occlusion
- 12-15ml saline with Doyens
healthy, nonanesthetized dogs showed maximum
intraluminal pressures induced by peristalsis to be
between 15 and 25 mmHg
All anastomoses can be made to leak with sufficient pressure
Intestinal Resection and Anastomosis
indications: for removal of ischemic, necrotic, neoplastic, granulomatous, or stenosed segments of intestine
- hand-sewn single-layer, simple interrupted approximating suture pattern
- 3-0 or 4-0 monofilament suture
- first and second sutures placed at the mesenteric and antimesenteric borders
- modified continuous pattern (imited retrospective report compares favorably with reports of complications from other techniques)
disparity between the luminal diameters of bowel ends
- sutures on the larger lumen side can be spaced farther apart than those of the smaller side (for mild cases)
- intestine with the smaller lumen can be transected at an angle
- spatulated
- lumen diameter of the larger segment can also be reduced