Ch. 18 Flashcards Preview

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Flashcards in Ch. 18 Deck (20):
1

Fever, fatigue, jaundice after eating shellfish, no chronic hepatitis

Hepatitis A

2

Elevated ALT/AST with potential for insulin resistance development

Hepatitis C

3

Scarring and rosette formation in hepatocytes with ANA, anti-SLA/LP, anti-LKM1, and ACL-1 abs

Autoimmune hepatitis

4

Elevated bilirubin, yellow liver, AST>ALT, lipid droplets in hepatocytes

Hepatic steatosis

5

Hepatic ballooning, Mallory-Denk bodies with hyperbilirubinemia, and elevated ALT/AST/AlkPhos

Alcoholic hepatitis

6

Chicken wire web formation leading to Laennec cirrhosis of the liver with portal fibrosis

Steatofibrosis

7

Hepatomegaly, abnormal skin pigmentation, arthritis, + Prussian blue stain, HFE or HAMP/HJV mutation

Hemochromatosis

8

Liver disease leading to movement disorders and + Rhodamine or Orcein stains with ATP7B mutation

Wilson disease

9

Cytoplasmic globular inclusions in hepatocytes due to unfolded protein response with PiZZ genotype

Alpha1-AntiTrypsin disease

10

Accumulation of bile pigment in the hepatic parenchyma with jaundice, DAKE deficiencies, elevated AlkPhos and GGT, and Feather Degeneration

Cholestasis

11

Influx of neutrophils into the bile duct

Ascending cholangitis

12

Hyperbilirubinemia in an infant for > 3 weeks with jaundice, dark urine, and acholic stools

Neonatal cholestasis

13

Florid duct lesions, feathery degeneration, Mallory-Denk bodies with elevated AlkPhos and GGT in a middle aged woman

Primary biliary cirrhosis

14

Onion skin fibrosis, biliary beading, pANCA abs, and elevated AlkPhos in middle aged man

Primary Sclerosing Cholangitis

15

Benign neoplasm developing from hepatocytes with no dysplasia

HNF1-a type hepatocellular adenoma

16

Benign neoplasm developing from hepatocytes with a high degree of dysplasia

ß-catenin type hepatocellular adenoma

17

Malignant growth with WNT and FOXG1 activations

Hepatoblastoma

18

Malignant growth causing elevated a-fetoprotein, fatigue, weight loss, ab pain, and hepatomegaly with ß-catenin and p53 mutations

Hepatocellular carcinoma

19

What's the difference between small-cell and large-cell change hepatocellular carcinomas

Small-cell = high Nuc:Cyt ratio with nuclear hyperchromasia
Large-cell = normal Nuc:Cyt ratio

20

Firm gray nodule in bile duct wall causing obstruction, RUQ pain, and cholangitis

Cholangiocarcinoma (adenocarcinoma)