Hepatitis Tx Flashcards Preview

Zak, GI 2 > Hepatitis Tx > Flashcards

Flashcards in Hepatitis Tx Deck (8)
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1
Q

What is the MOA of INF-a drugs for HBV?

A

Inhibit viral DNA integration into host DNA via ZAP

2
Q

What is the MOA of Nucleoside/nucleotide drugs?

A

Inhibit reverse transcriptase and DNA polymerase from the virus

3
Q

Which drug would you use for HBV first line that is easy on the kidney?

A

Entecavir

4
Q

Which drug would you use for wild-type HBV first line that causes proximal renal tubule disease?

A

Tenofovir

5
Q

Which HCV drug inhibits NS5B?

A

Sofosbuvir

6
Q

Which HCV drugs inhibits NS5A?

A

Ledipasvir, Elbasvir, Velpatasvir

7
Q

What is the Genotype 1 drug regimen for HCV Tx?

A

Ledipasvir + Sofosbuvir

8
Q

What are the Genotype 2 drug regimens for HCV Tx?

A

Velpatasvir + Sofosbuvir

Elbasvir + Grazoprevir