Flashcards in Diarrhea/Constipation Tx Deck (21):
What are the opioid agonists for diarrhea Tx?
Loperamide, Diphenoxylate, Eluxadoline
What is the MOA of Loperamide?
Decrease GI transit time
What is the MOA of Diphenoxylate?
Inhibit GI motility
What is mixed with Diphenoxylate to prevent addiction?
What is the MOA of Eluxadoline?
Opioid agonist in GI (C-IV)
What is the SE associated with Eluxadoline?
Pancreatitis in pts with no gallbladder
What is MOA of Alosetron?
Inhibits GI 5-HT3R
When is Alosetron used?
When severe IBS-D is unresponsive to other Tx
What is the major SE of Alosetron?
Constipation --> Ischemic colitis
What is the MOA of Crofelemer?
Inhibits Cl secretion by CFTR
When is Crofelemer used?
In non-infectious diarrhea in HIV/AIDs pts
What type of drugs are used for abdominal pain?
When would you not give a saline agent for constipation?
In pts with renal disease, CHF/HTN
Which constipation drug family would you give to a pt with severe liver disease?
Which drug can be taken daily in small doses for constipation?
What is the difference between Methylnaltrexone and Naloxegol?
Methylnaltrexone is IV
Naloxegol is PO
What is the MOA of Methylnaltrexone and Naloxegol?
Opioid receptor antagonists (OIC)
What is the MOA of Linaclotide?
Stimulates secretion of Cl/HCO3 from CFTR channel into GI lumen
When is Linaclotide used?
What is the MOA of Lubiprostone?
PGE1 derivative that increases GI Cl channel secretion