Diarrhea/Constipation Tx Flashcards Preview

Zak, GI 2 > Diarrhea/Constipation Tx > Flashcards

Flashcards in Diarrhea/Constipation Tx Deck (21):
1

What are the opioid agonists for diarrhea Tx?

Loperamide, Diphenoxylate, Eluxadoline

2

What is the MOA of Loperamide?

Decrease GI transit time

3

What is the MOA of Diphenoxylate?

Inhibit GI motility

4

What is mixed with Diphenoxylate to prevent addiction?

Atropine (C-V)

5

What is the MOA of Eluxadoline?

Opioid agonist in GI (C-IV)

6

What is the SE associated with Eluxadoline?

Pancreatitis in pts with no gallbladder

7

What is MOA of Alosetron?

Inhibits GI 5-HT3R

8

When is Alosetron used?

When severe IBS-D is unresponsive to other Tx

9

What is the major SE of Alosetron?

Constipation --> Ischemic colitis

10

What is the MOA of Crofelemer?

Inhibits Cl secretion by CFTR

11

When is Crofelemer used?

In non-infectious diarrhea in HIV/AIDs pts

12

What type of drugs are used for abdominal pain?

Antimuscarinic's

13

When would you not give a saline agent for constipation?

In pts with renal disease, CHF/HTN

14

Which constipation drug family would you give to a pt with severe liver disease?

Osmotic agents

15

Which drug can be taken daily in small doses for constipation?

PEG-3350

16

What is the difference between Methylnaltrexone and Naloxegol?

Methylnaltrexone is IV
Naloxegol is PO

17

What is the MOA of Methylnaltrexone and Naloxegol?

Opioid receptor antagonists (OIC)

18

What is the MOA of Linaclotide?

Stimulates secretion of Cl/HCO3 from CFTR channel into GI lumen

19

When is Linaclotide used?

IBS-C, CIC

20

What is the MOA of Lubiprostone?

PGE1 derivative that increases GI Cl channel secretion

21

When is Lubiprostone used?

IBS-C, CIC, OIC