Nausea/Vomiting Tx Flashcards Preview

Zak, GI 2 > Nausea/Vomiting Tx > Flashcards

Flashcards in Nausea/Vomiting Tx Deck (19):
1

Which 5-HT3R antagonists have the longer half life?

Palonosetron, Gransetron ER

2

Which 5-HT3R antagonist is has the greatest risk of causing a prolonged QT interval?

Dolasetron

3

Which NK1R antagonists are given prior to surgery?

Aprepitant, Fosaprepitant

4

What are the H1R antagonists used for?

NVP, motion sickness, vertigo

5

What are the 5-HT3R antagonists used for?

CINV, PONV, RINV, NVP

6

What are the NK1R antagonists used for?

CINV, PONV

7

What are the D2R antagonists use for?

Gastroparesis, dysmotility

8

Which D2R antagonist also stimulates Ach release?

Metoclopramide

9

When pts are on what other medication are D2R antagonists contraindicated?

Anti-HTN meds

10

What are the M1R antagonists used for?

Motion sickness

11

What are the cannabinoid agonists used for?

Tx-resistant CINV

12

What is the difference in metabolism in the cannabinoids?

Dronabinol --> single metabolite
Nabilone --> many metabolites

13

What is the 3-drug regimen for CINV?

NK1R antag, 5-HT3R antag, Dexamethasone

14

What is the 2-drug regimen for CINV?

5-HT3R antag, Dexamethasone

15

What is the 1-drug regimen for CINV?

Dexamethasone OR 5-HT3R antag OR D2R antag

16

Which drugs are used for motion sickness?

Scopolamine, Dimenhydrinate, Meclizine

17

Which drugs are used for vertigo?

Meclizine, Cyclizine

18

Which drug is used for diabetic gastroparesis?

Metoclopramide

19

Which drug is first line for NVP?

Doxylamine