Flashcards in Chapter 10: Adrenergic Pharmacology Deck (52)
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1
alpha-methyltyrosine
inhibits tyrosine hydroxylase (RL step) to prevent formation of catecholamines
Not really used clinically because there are better medications for hypertension
2
reserpine
irreversibly inhibits VMAT so that vesicles cannot store dopamine and NE
Not really used clinically since it is irreversible
But can be used to assess what concentration of a drug is needed
3
Guanethidine
acts as a "false neurotransmitter" and is transported into neurons by NET....essentially displaces NE
can lead to postural hypotension or hypotension after exercise
TX: hypertension
Don't use with MAOI
4
Guanadrel
Same as Guanethidine
Tx: hypertension
5
Amphetamine
MOA: displace catecholamines from storage, block NE reuptake by NET, weakly inhibit MAO
TX: ADHD & narcolepsy
Lots of side effects (addiction potential, loss of appetite, irritability, ED)
6
Methylphenidate
MOA: displaces catecholamines from storage vesicles, blocks NE reuptake by NET, weakly inhibit MAO
TX: ADHD
A lot of side effects
7
Pseudophedrine
MOA: inhibits catecholamine storage in vesicles
TX: allergic rhinitis & nasal decongestion
"Sudafed" - over the counter decongestant
DO NOT USE W MAOIs
8
Cocaine
MOA: inhibit NET reuptake (allows accumulation of NE in synpatic cleft)
TX: sometimes local anesthetic; drug abuse
9
Imipramine
Same as Cocaine
10
Amitriptyline
Basically same as Cocaine; used as an antidepressant
11
Phenelzine
MAOI for depression tx
12
Iproniazid
MAOI for depression tx
13
Tranylcypromine
MAOI for depression tx
14
Selegiline
MAOI used for Parkinson tx
15
Why can't you use MAOIs with SSRIs?
BAD NEWS! SEROTONIN SYNDROME! = seizures, coma, death
16
What type of foods must you avoid if taking MAOIs?
Fermented foods that contain tyrosine - think red wine or aged cheese.
Why? Risk of hypertensive crisis.
17
Nemonic for 3 major MAOIs?
When you're in the PITS, take MAOIs
P - phenelzine
I - iproniazid
T - tranylcypromise
S - selegiline
18
Alpha 1 agonist function?
increase peripheral resistance to maintain or increase blood pressure
19
Methoxamine
MOA: alpha 1 agonist
TX: hypotension, shock
Very limited clinical use for Shock
20
Phenylephrine
Oxymetazoline
Tetrahydrozoline
the "POT" triad
MOA: alpha 1 agonist
TX: nasal congestion
Use over the counter for nasal congestion, eye congestion
Rebound symptoms are common is used for over 3 days...sick. literally.
*when you smoke pot your eyes get red and runny! use POT!
21
Alpha 2 agonist function?
Inhibits sympathetic outflow from the CNS --> lowers blood pressure
22
Clonidine
MOA: alpha 2 agonist
TX: hypertension, opioid withdrawal, cancer pain
23
Dexmedetomidine
MOA: alpha 2 agonist
TX: sedation of surgical and ICU patients
ANESTHESTIC - LIKE!
24
Methyldopa
MOA: alpha 2 agonist
TX: hypertension in Preggo Ladies
25
Beta 1 agonist function?
stimulates heart and raises BP via renin
26
Beta 2 agonist function?
relaxes smooth muscle and increases gluceoneogenesis
Think of bronchodilation for ASTHMA
27
Isoprotenol
Non-selective B1 B2 agonist, meaning it can help with asthma buttt
you will also have adverse heart effects
- increased HR, irregular respirations, etc.
28
Dobutamine
This is the dude with the weird racemic mixture crap! Basically A1 agonist/antagonist actions cancel each other out so you're left with:
B1 agonist behavior
TX: IV for urgent & severe heart failure
29
Metaproterenol
MOA: B2 selective agonist
Asthma
30
