Chapter 17: Analgesics Flashcards Preview

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Flashcards in Chapter 17: Analgesics Deck (67)
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1

Morphine

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

2

Codeine

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

3

Oxycodone

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

4

Hydrocodone

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

5

Tramadol

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

6

Methadone

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

7

Fentanyl

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

8

Alfentanil

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

9

Sufentanil

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

10

Ramifentanil

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

11

Meperidine

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

midriasis - pupils big and wide

12

Levorphanol

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

13

Propoxyphene

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

14

Butorphanol

Partial μ-receptor agonist

15

Buprenorphine

Partial μ-receptor agonist

16

Nalbuphine

κ-agonist with partial μ-antagonist activity

17

Naloxone

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

18

Naltrexone

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

19

Alvimopan

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

20

Methylnaltrexone

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

21

Acetaminophen

NSAID - Affect prostaglandin synthetic pathway

22

Aspirin

NSAID - Affect prostaglandin synthetic pathway

23

Naproxen

NSAID - Affect prostaglandin synthetic pathway

24

Ibuprofen

NSAID - Affect prostaglandin synthetic pathway

25

Indomethacin

NSAID - Affect prostaglandin synthetic pathway

26

Diclofenac

NSAID - Affect prostaglandin synthetic pathway

27

Piroxicam

NSAID - Affect prostaglandin synthetic pathway

28

Celecoxib

NSAID - Affect prostaglandin synthetic pathway

29

Diclofenac

NSAID - Affect prostaglandin synthetic pathway

30

Keterolac

NSAID - Affect prostaglandin synthetic pathway

31

Amitirptyline

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

32

Nortriptyline

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

33

Imipramine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

34

Desipramine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

35

Duloxetine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

36

Venlafaxine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

37

Carbamazepine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

38

Oxcarbazepine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

39

Gabapentin

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

40

Pregabalin

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

41

Lamotrigine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

42

Mexiletine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

43

Ketamine

Blocks NMDA receptor-dependent postsynaptic depolariztion

44

Dextromethorphan

Blocks NMDA receptor-dependent postsynaptic depolariztion

45

Sumatriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

46

Rizatriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

47

Naratriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

48

Zolmitriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

49

Almotriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

50

Eletriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

51

Which drugs prevent morphine induced constipation, but have no effect on morphine analgesia?

Alvimopan and Methylnaltrexone

52

Which drugs do you have to avoid if there is use of a MOAI, in order to avoid seretonin syndrome?

Dextromethorphan and Meperidine

53

Which drugs active metabolite, M6G, is excreted in the kidney?

Morphine

54

Which of these drugs is the most potent: Fentanyl, Alfentanil, Sufentanil?

Sufentanil

55

Which of these drugs is the least potent: Fentanyl, Alfentanil, Sufentanil?

Alfentanil

56

Due to its long duration of action, which drug is used to achieve long lasting pain relief in cancer patients?

Methadone

57

Which opioid causes mydriasis rather than miosis?

Meperidine

58

Which pain control drug may precipitate withdrawl in patients who have received opioids chronically?

Nalbuphine

59

Which u-opioid receptor agonist has minimal abuse potential?

Tramadol

60

Which drug has an unusually rapid metabolism and elimination rate?

Ramifentanil

61

Which drug cannot be given via an epidural or intrathecally, because the glycine in the formulation may cause neurotoxicity?

Ramifentanil

62

Which drugs produce morphine-like analgesia with milder euphoric effects?

Butorphanol and Buprenorphine

63

Which drug’s usage is limited due to it’s psychomimetic effects?

Ketamine

64

Which drug is used for anesthesia, that has minimal risk of respiratory depression?

Ketamine

65

Which drug is used to treat neuropathic pain as well as the cough?

Dextromethorphan

66

Which drug can be used to treat opioid and alcohol addiction?

Naltrexone

67

Which drug can only be used to treat acute oipoid toxicity?

Naloxone