Chapter 30: Endocrine Pancreas & Glucose Homeostasis Flashcards Preview

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Flashcards in Chapter 30: Endocrine Pancreas & Glucose Homeostasis Deck (26)
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1

Acarbose: mechanism of action

alpha glucosidase inhibitor

2

Miglitol

alpha glucosidase inhibitor

3

Voglibose

alpha glucosidase inhibitor

4

Acetohexamide

First generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

5

Chloropropamide

First generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

6

Tolazamide

First generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

7

Tolbutamide

First generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

8

Glimepiride

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

9

Glipizide

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

10

Glibenclamide

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

11

Glyburide

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

12

Gliclazide

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

13

Gliquidone

Second generation sulfonylurea: inhibits the ATP/K+ pump in B cells to promote insulin secretion

14

Nateglinide

Meglitidine: inhibits the ATP/K+ pump in B cells to promote insulin secretion

15

Repaglinide

Meglitidine: inhibits the ATP/K+ pump in B cells to promote insulin secretion

16

Metformin

Insulin Sensitizer: Bigaunides. Activated AMP Dependent protein kinase. Blocks synthesis of fatty acids and inhibits hepatic gluconeogenesis and glycogenolysis. Increases insulin recepto activity and responsiveness in liver and skeletal muscle

17

Pramlintide

Amylin analogue: released from B cell along with insulin. Acts on CNS to slow gastric emptying and reduce glucose and glucagon release after meals. Makes you feel full too.

18

Exenatide

GLP-1 analogue. Enhances insult secretion. Inhibits glucagon secretion. Decrease appetite. Delay gastric emptying.

19

Liraglutide

GLP-1 analogue. Enhances insult secretion. Inhibits glucagon secretion. Decrease appetite. Delay gastric emptying.

20

Sitagliptin

DDP-4 inhibitor. DDP-4 blocks GLP-1. Enhances insult secretion. Inhibits glucagon secretion. Decrease appetite. Delay gastric emptying.

21

Saxagliptin

DDP-4 inhibitor. DDP-4 blocks GLP-1. Enhances insult secretion. Inhibits glucagon secretion. Decrease appetite. Delay gastric emptying.

22

Pioglitazone

TZD: Insulin Sensitizer: binds to PPAR-y to make adipose, liver, and muscle more sensitive to insulin.

23

Rosiglitazone

TZD: Insulin Sensitizer: binds to PPAR-y to make adipose, liver, and muscle more sensitive to insulin.

24

Diazoxide

Binds to SUR1 subunit of ATP/K+ channel in the pancreatic B cells. Keeps channel open so that insulin secretion is DECREASED.

25

Octreotide

Somatostatin analogue - inhibits GHRH release

26

Glucagon

produced by alpha cells and stimulates gluconeogenesis and glycogenolysis in liver. INCREASES BLOOD SUGGGAAAAA