Chapter 11 Part II (QUIZ) Flashcards Preview

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Flashcards in Chapter 11 Part II (QUIZ) Deck (49)
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1

Sickle cell anemia is autosomal ______ with an mutation/instability of the _____ globin

recessive
B-globin

2

8% of African Americans are ______ or _____

heterozygous carriers

3

sickling --> _______ obstruction

microvascular obstruction

4

locations of sickle cell anemia occurs in areas of _____; bone marrow, spleen; usually has symptoms of _____ and _____/inflammation

stasis
dehydration
infection

5

thrombosis, chronic low-level pain, joint pain, priapism, fever, malaise, splenomegaly/infarction, gallstones are symptoms of

sickle cell anemia

6

heterozygous carriers for sickle cell anemia are RARELY _____ ; homozygous: ___% survive beyond 5th decade

symptomatic
50%

7

MC cause of death in someone with SCA (2)

acute chest syndrome
stroke

8

MC location of congestion/infarction for SCA

bone marrow

9

vertebral involvement in SCA is called _______; microvascular endplate infarctions with central endplate depression

Lincoln log vertebra (H-shaped vertebra)

10

thalassemia is autosomal ________ with abnormal ______ PRODUCTION

recessive
hemoglobin

11

hemoglobin shape in thalassemia (2)

microcytic (small)
hypochromic (pale)

12

areas of endemic malaria (2)

africa
SE asia

13

B-thalassemia is on chromosome ____

11

14

A-thalassemia is on chromosome ___

16

15

mutation in thalassemia is excess of the ________ globin chain

opposite

16

in thalassemia, there is damage to _____ called HEMOLYSIS and damage to ____

RBCs
erythroblasts

17

in ______ thalassemia, there is decreased B-globin chain synthesis and excess of unpaired A chains

B-thalassemia

18

aka B-thalassemia trait; features are ASYMPTOMATIC or MILD; normal life span of RBC; treatment is often not necessary

B-thalassemia minor

19

type of B-thalassemia that has severe hemolysis/anemia with SKELETAL DEFORMITIES; leads to eventual IRON OVERLOAD

b-thalassemia major

20

the eventual iron OVERLOAD in b-thalassemia is called _______ and leads to lethal ______

hemochromatosis
cardiomyopathy

21

a-thalassemia involves ____ a-globin gene, and _____ B-globin

mutated
excess

22

a-thalassemia is ____ severe than b-thalassemia

less

23

__-thalassemia is HIGHLY variable, with __ total globin chains

a-thalassemia
4 (higher # = more severe)

24

function is to neutralize oxidants that may cause hemolysis

glutathione (GSH)

25

enzyme needed for GSH synthesis

G6PD

26

a type of hemolytic anemia in which a deficiency --> DECREASE GSH --> HEMOLYSIS

glucose 6-phosphate dehydrogenase deficiency (G6PD)

27

MC method of decrease GSH production is

deficiency of G6PD

28

who is most affected with G6PD?

males (x-linked)

29

MC environmental stimulus that creates oxidative stress with G6PD (asymptomatic until environmental stimulus)

infection
(others are ADRs and fava beans)

30

oxidation in G6PD is associated with _____ PHAGOCYTOSIS

splenic