Chapter 20 Arthritis and Other Connective Tissue Diseases Flashcards Preview

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Flashcards in Chapter 20 Arthritis and Other Connective Tissue Diseases Deck (18):
1

Rheumatic disease definition

any disease or condition involving the musculoskeletal system.

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Arthritis definition

inflammation of one or more joints

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Osteoarthritis

Noninflammatory arthritis
Not systemic
Not an autoimmune disease
Most common type of arthritis
Progressive loss of cartilage

4

Inflammatory arthritis types

Rheumatoid arthritis
Systemic lupus erythematosus

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Osteoarthritis clinical manifestations

Heberden's nodes
Bouchard’s nodes
Joint effusions
Atrophy of skeletal muscle

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Osteoarthritis labs

erythrocyte sedimentation rate and C-reactive protein may be slightly elevated

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Tests used to dx Osteoarthritis

MRI, CT, Radiograph, labs

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Rheumatoid Arthritis

Connective tissue disease
Destructive to joints
Chronic, progressive, systemic inflammatory autoimmune disease
Rh factors attach synovium

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Early RA sx

manifestations—joint stiffness, swelling, pain, fatigue, and generalized weakness and morning stiffness

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Late RA sx

joints become progressively inflamed and painful

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Syndromes associated with RA

Sjögren’s syndrome
Felty’s syndrome
Caplan’s syndrome

12

RA labs

assessment—rheumatoid factor, antinuclear antibody titer, erythrocyte sedimentation rate, serum complement, serum protein

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RA diagnostic assessments

x-ray, CT, arthrocentesis, bone scan

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RA drug therapy

Disease-modifying antirheumatics
NSAIDs
Biologic response modifiers
Glucocorticoids
Immunosuppressive agents

15

Lupus Erythematosus

Chronic, progressive, inflammatory connective tissue disorder
Autoimmune
Remissions and exacerbations
Often involves kidneys

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Clinical Manifestations of LE

Polyarthritis
Osteonecrosis
Muscle atrophy
Fever and fatigue
Renal involvement
Pleural effusions
Pericarditis
Raynaud’s phenomenon
Butterfly rash

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LE diagnostics

Skin biopsy (confirms dx)
CBC
Immunologic lab tests

18

LE drug therapy

Plaquenil
Tylenol or NSAIDs
Chronic steroid therapy
Immunosuppressive agents