Chapter 3 Flashcards
(108 cards)
what influences gene expression
transcription factors
gene expression influences
effector function
examples of effector functions
- production of AMPs
- increase phagocytosis
- cytokines production
- proliferation
- activating other cells
self vs non-self vs altered self are considered what
ligands
self ligands are
healthy human cells
healthy human cells do what
do not initiate a response
non-self ligands are
microbial cells
microbial cells in non-self ligands activate what
immune system
altered self ligands are
infected or cancerous cells
infected or cancerous cells initiate
an immune response
in self ligands, if you have a response what do you have
an autoimmune disease
tissue resident macrophage can signal through
channels
functions of tissue resident macrophages
- long lived
- capacity to self renew
- scavengers- hanging in the tissues to clean up dead and dying cells
- phagocytosis
SR-A1
SR-A6
SR-B2
SR-E2
SR-E3
are what
scavenger receptors
+ or - phagocytosis and signaling
+ for phagocytosis
- for signaling
for toll like receptors what is neg and pos for signaling and phagocytosis
-: phagocytosis
+ for signaling
the mannose receptor has how many extracellular domains of 4 types
10
receptor binds ligand and the surface sugars of a bacterium are bound by two?
CTLD domains
macrophage ingests bacterium by
receptor- mediated endocytosis
bacterial degradation begins in the
endosome
endosome fuses with lysosome to form
phagolysosome in which bacterium is further degraded
what happens to the mannose receptor at the end of this
the mannose receptor is returned to the cell surface and is recycled
what is the structure if toll-like receptor 4
leucin-rish repeats which bind PAMPS
TIR domain which is the signaling domain
TLR ligands include
plasma membrane receptors
endosomal receptors
