Chapter 9 Flashcards
(86 cards)
do antibodies in different locations function the same or differently
differently
antibodies in the blood, lymph, and extracellular fluids function how
by binding microbes -> aggregation, neutralization, and complement activation
antibodies in mucusal surface function how
by trapping microbes in the mucus layer
b cell activation generating high affinity receptors would include what
somatic hypermutation and affinity maturation
what cells do somatic hypermutation
TFH cells
what cells do affinity maturation
FDCs
b cell activation becoming antibody factories (plasma cells) include
class switching
what cells are involved in class switching
TFH cells
where does cross-linking BCR inducing signaling occur
secondary lympoid organs
BCR binds multiple what on the surface of microbes
epitopes
what does the binding of epitopes result in
cross-linking BCRs
after the BCR binds multiple epitopes on the surface of microbes creating cross linking what happens
kinase of ITAMS on Ig alpha/beta
after the BCR binds multiple epitopes on the surface of microbes creating cross linking what happens and kinase of ITAMs on Ig alpha/ beta what happens
activation signals are sent to the nucleus and create in gene expression
what does CR2 do
bind to Ag via C3d
what is CD19
signaling domain
what is CD81
membrane localization of complex
CR1 (b cell) binds what and on what
C3b on pathogen
once CR1 binds Csb on pathogen what is recruited
factor I
what does factor I do
cleaves C3b-> iCsb -> C3d
what does C3d bind
CR2
B cell signaling for whole microbe
- BCR bind to antigen
- coreceptor bind C3d
- signaling from BCR and coreceptor converge
b cell signaling for part of microbe
- BCR bind a component of microbe
- C3d binds to same component and CR2
- converge on signaling
2 ways to activate B cellls is
thymus independent and dependent
thymus independent includes what b cells
B1 and B2
