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Flashcards in CHAPTER: Neuro Path Deck (27):
1

2 histo findings and where each are found for Alz - which correlates with the degree of dementia?

NF tangles = tau = intra-cell
# tangles correlates with degree of dementia
AB amyloid - plaques @ gray matter
Complication amyloid angiopathy -> intracranial hemm

2

What are Pick bodies? How does their location in the brain contribute to symptoms?

Pick = tau
@ frontal cortex = behavioral changes
@ temporal cortex = language changes (aphasia)
Can progress to dementia

3

Presentation of Lewy body dementia

Dementia :
1. Visual hallucinations
2. Parkinson features (tremor) - once LBs infiltrate SN

4

Presentation osmotic demyelination syndrome before it progresses to locked in syndrome

Acute paralysis
Change speech
Diplopia
Lose consciousness
Think PONS

5

What happens if you correct HYPERna too fast?

Cerebral edema + herniation

6

Presentation of MS

Sudden vision loss w/ blown pupils
INP
Hemiparesis / sensory loss
Bladder/bowel problems
SIN:
Scanning speech
Intention tremor
Nystagmus

7

Dx MS labs + imaging

Labs: oligoclonal Ig in CSF + myelin basic protein (from demyelin)
Perventi spots on MRI separated in space + time

8

You know GB presents with ascending paralysis - what are other presentations

↑ICP b/c ↑protein in CSF -> papilledema
Facial paralysis
Autonomic dysreg: ↑HR, ↓BP

9

What CNS change might occur after chicken pox//measles infection or rabies//small pox vaccine

Peri-vent demyelin
Lesions all at 1 time (vs MS)

10

Inheritance, problem and presentation of Charcot Marie Tooth disease

AD - can't make proteins for myelin or peripheral nerves
1. High arch foot
2. LE weakness

11

Inheritance, enzyme def, accum proteins of Krabbe

AR - lysosomal storage
X galactocerebrosidase
↑GC + psychosine = causes damage

12

Symptoms + histo findings Krabbe

Peripheral neuropathy
Mental delay
Optic atrophy
Globoid cells on histo

13

Inheritance, enzyme def, accum of proteins of MCLD

AR - lysosomal storage
X Aryl-sulfatase A
↑Sulfatides

14

Symptoms of MCLD

Peripheral AND central demyelinaiton
Ataxia + dementia

15

Inheritance adrenoleukodystrophy

XL - can't breakdown very long chain FAs

16

Most common origin partial seizures

Medial temporal lobe

17

3 substances released that cause migraines

Sub P
Calcitonin gene related peptide - CGRP
Vasoactive peptides

18

What's the difference between trigeminal neuralgia vs cluster headaches?

Trigem = lasts seconds
Cluster = mins/hrs

19

Describe nystamgus of peripheral vs central vertigo

Peripheral = delayed horizontal
Central = immediate nystagmus in any direction (brain stem or cerebellar lesion)

20

Tumor syndrome that presents with
Hemangioblastomas in the brain + spine
Cavernous hemangiomas in skin/organs
Bilat RCC
Pheo

VHL - chr 3

21

Disease + inheritance of:
Cafe au lait
Lisch nodules = iris hamartomas
Cutaneous neurofibromas
Optic gliomas
Pheo

NF1- chr 17
AD w/ full penetrance but variable expression
Parent and child with same disorder but different symptoms

22

Problem + symptoms of Sturge Weber

Somatic mutation - bad neural crest cells
1. Port wine birth mark on V1/2 dist of face
2. Angiomas in brain -> seizures
3. ↑IOP -> early glaucoma

23

Adult tumor that presents in frontal lobes

Oligodendroglioma

24

Adult tumor with thin walled capillaries and little parenchyma in the middle

Hemangioblastoma - makes sense! Think VHL

25

Which adult tumor is S100 +

Schwannoma

26

Kid tumor that is HW rosettes and can cause drop mts

Medulloblastoma

27

What kid tumor looks like germ cell tumors

Pinealoma