Immuno Drugs Flashcards Preview

LCK STEP > Immuno Drugs > Flashcards

Flashcards in Immuno Drugs Deck (14):
1

Diseases you give IL 2 for (increase NK activity)

RCC
Met melanoma

2

Diseases you give G-CSF (filgrastim) + GM-CSF (sargramostim) for

Recovery bone marrow

3

Diseases you give IFN alpha for

Chronic Hep B + C
HHV 8
Melanoma

4

Diseases you give IFN beta for

MS

5

Diseases you give IFNg for

CGD

6

Diseases you give romiplostim, eltrombopag, oprelvekin (IL 11) for

TCP

7

Den-OS-umab

Binds RANK-L
X osteoclast maturation
Osteoporosis

8

Abs vs VEGF - what are they (2), which disease use them for

Use for age macular degen b/c wet bleeding from neovasc causing rapid vision loss
1. RAN-ibizumab
2. BEVA-cizumab - also for CRC + RCC

9

mAb give for paroxysmal nocturnal hemoglobinuria

Eculizumab = vs C5
PNH - patient doesn't have GPI to anchor protection proteins
No CD55 - C5 doesn't give a fuck (DAF) - lysis at night when blood pH goes up

10

You give TNFa Abs for many AI disease - name the 4 Abs you could use

Adalimumab
Infliximab
Certolizumab
Etanercept "intercepts" TNFa = decoy receptor

11

2 drugs that affect calcineurin + SEs

Cyclosporine
1. Nephro > neurotox (but both still risk)
2. Gingival hyperplasia
3. Histuism
Tacrolimus
1. Neuro > nephrotox
2. Diabetes

12

mTOR I + SEs

Sirolimus // ripamycin
Think sirolimus + cyclosporine combo
1. Pan-SIR-topenia
**NOT nephrotox - use for kidney transplant pts

13

IL2 Abs

DAC-lizumab
BAS-iliximab

14

2 drugs that stop purine synthesis for immune suppression

Azothio-purine (= 6MP)
**Watch for combo with allopurinol - ↓XO will ↑6MP - see ↓all bone marrow products
MMF Xs IMP deH