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LCK STEP > Cytokines to Know > Flashcards

Flashcards in Cytokines to Know Deck (17):
1

Name 5 cytokines secreted by macrophages

IL 1, 6, 8, 12, TNF alpha

2

Which cytokine increases APRs?

IL 6

3

2 cytokines secreted by ALL T cells

IL 2 + 3

4

What cytokine do Th1 cell secrete? 4 fxns

IFNg
1. Activates NK cells
2. Increases MHC expression + antigen presentation by all cells (show me what you've got!!!)
3. Activates macrophages
4. Blocks Th2 conversion

5

3 cytokines secreted by Th2 cells?

IL 4, 5, 10

6

IL 1

= osteoclast activating gactor
FEVER b/c increase PGE2 at hypothalamus
Activates endo to express adhesion molecules
Recruit WBC

7

IL 8

Neutrophil chemotaxis to clear infections
"clean up on aisle 8"

8

IL 12

Th1 differentiation
NK activation

9

TNF alpha

Septic shock
Endo activation, vasc leak, WBC recruit
Is what causes WEIGHT LOSS in cancer

10

IL 2

Stim
1. Helper + cytotox T cells
2. Reg T cells
3. NK cells

11

IL 3

Bone marrow stem cell differentiation

12

IL4

Th2 differentiation
Switch to IgE (and IgG)

13

IL 5

IgA switch
Eosinophils

14

IL 10

atTENuate the immune response (along w/ TGF beta)

15

Hot
Tbone
stEAK

IL 1 - hot (fever)
2 - stim T cells
3 - bone marrow prod
4 - IgE
5 - IgA (5 am = red sunrise = eosinophils)
6 - IgG + aKute phase reactant

16

Difference in fxn between IFN a/b and IFN g

IFNa/b - made and released by virally infected cells so that local neighbors enter non-infectious state by *degrading viral nucleic acids + protein*
IFNg activates macro, Th1, NK (also anti-tumor by making tumors increase MHC 1 expression
"Alpha activates, B be less"

17

Which cytokine maintains granulomas

Think TB
Infected macrophage secretes IL 12 -> activated T/NK cells -> secrete *IFNg* -> binds Janus kinases 1+2 -> STAT1 TF -> activate genes for M.TB killing
Defective IFNg R -> disseminated TB disease