Teratogens Flashcards Preview

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Flashcards in Teratogens Deck (17):
1

ACE + ARB

Renal damage

2

Aminoglycosides

Oto-tox

3

Anti-epileptic drugs: valproate, carbamazepine, phenytoin, phenobarbital

B/c folate antag - neural tube defects - if mom has to stya on this drug, you need to + high dose folate supplement
CArdiac defects
Cleft palate
Skeletal abnormalities

4

Diethylstilbestrol

Vaginal clear cell adenocarcinoma
Congenital Mullerian anomalies

5

TMP, MTX

Aka anti-folate drugs = neural tube defects

6

Isotretinoin

Vit A -> many defects and high rate spon abortion
Must be on birth control to be on acutane

7

Lithium

Ebstein's anomoly = atrialization of the RV

8

Methimazole

For hyperT -> stop peroxidase rxns in colloid
Aplasia cutis congenita - hole on top of your head doesn't close

9

Tetracyclines

Discolored teeth
Inhibit bone growth
Teeth-racycline

10

Thalidomide

1950s for AM sickness -> limb defects
Tha-limb-domide
Now used in cancer

11

Warfarin

Small and lipophilic molecule so crosses placenta -> bone, hemorrhage, eye
Instead use HWM heparin

12

Cocaine

Placenta abruption b/c vasoconstrictor

13

Smoking

Nicotine = vasoconstrict; CO impairs O2 delivery to fetus
Low birth weight
Early deliverly
Placental problems

14

Maternal diabetes

Caudal regression syndrome - anal atresia to sirenomelia (mermaid baby)
Transposition of the great vessels

15

Mercury (why no raw fish)

Neurotox

16

Second hand smoke effects on newborn

SIDS
Otits media
Asthma

17

Valproate

Neural tube defects (-celes)