Flashcards in Cholesterol Metabolism Deck (26):
Member of _____ protein family of transporters can transport cholesterol
ATP-binding Cassette (abc)
ABC transporter such as ABCG5 and ABCG8 couple _____ to transport of unwanted or excessive _____ and plant sterols from enterocyte back into gut lumen.
What's the ligands for LDL receptors?
apoB100 and apoE
LDL receptor expression is induced by ___ in the cell
Low free cholesterol level
Familial hypercholesterolemia is caused by mutation in ___
LDL receptor- related protein (LRP) 's ligand is _____, and binds to ___ or ____
LDL receptor- related protein (LRP) is not affected by increase in _____
Intracellular cholesterol concentration
Superoxide radicals, nitric oxide, hydrogen peroxide and other oxidants promotes the oxidation of ____, therefore ______ such as vitamin c, vitamin E and carotenoids offer protection against _____ diseases.
Define reverse cholesterol transport
Transport of cholesterol from peripheral tissues back to liver for metabolism
_____ is a major player in the process of reverse cholesterol
HDL has 3 forms:
Pre beta HDL
Hepatic lipase hydrolyzes _____ and is activated by _____
_____ activates HL, promoting at conversion to less mature HDL. This accounts for the lower HDL level
Defective ABCA1 reduces ____, and accumulate _____ in liver and peripheral tissue, cause _____ disease
Ezetimibe is a drug that blocks cholesterol absorption in the ______, causing a portion of dietary cholesterol to be carried into fece rather than chylomicron.
Mature HDL is primarily cleared through ______ expressed in many cell types
Hmg-coA reductase converts ____ to _____
Hmg-coA synthase used in cholesterol synthesis is present in _____ and is distinct from the mitochondrial hmg-coA synthase involved in ketone body generation
Hmg coA synthase converts ___ to ___
Hmg-coA reductase resides on the ______ with its n-terminal catalytic domain facing the cytosol.
While SR-BI is used primarily for HDL, ____ are present of macrophages
SR-AI and SR-AII
The continued uptake of oxidized ____ particle by the SR-AI and SR-AII will results in the formation of ____
______ accounts for 2/3 of plasma cholesterol
Cholesterol synthesis occurs in the _____
Cycliczation of squalene to lanosterol is preceded by ___ formation involve oxygen and ____