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Flashcards in Nitrogen Metabolism Deck (27):
0

Most amino acid degradation occurs in the ______

Liver

1

During transamination, amino group of an amino acid is transferred to ____, forming _____

A-ketoglutarate
Glutamate

2

All amino acid, except _____ can participate in transamination

Lysine
Threonine

3

Transamination reaction are catalyzed by ____, and requires ___ as coenzyme

Aminotransferase
Pyridoxal phosphate(PLP)

4

alanine amino transferase converts alanine to ______

Pyruvate

5

Aspartate amino transferase converts aspartate to _____

Oxaloacetate

6

Oxidative deamination occurs in the ____

Mitochondria

7

Glutamate dehydrogenase is inhibited by ____ and activated by ______

ATP GTP NADH
ADP GDP

8

Glutamine is made from glutamate using the enzyme ______, the enzyme adds a ____ to glutamate

Glutamate synthetase
NH4+ ammonia

9

Glutamine is converted back to glutamate by _____ in the liver

Glutaminase

10

_____ converts IMP to AMP, _____ converts IMP to GMP

Adenylsuccinate synthetase
IMP dehydrogenase

11

The base of IMP (inosine mono phosphate) is ___

Hypoxanthine

12

Hypoxanthine + PRPP = ______
Catalyzed by ____

IMP
HGPRT

13

Xanthine is converted to Uric acid by ____

Xanthine oxidase

14

Endonuclease converts ___ to ____

Nucleus acid
Monophosphate

15

___ and ____ convert mono phosphate to nucleoside

Phosphatase
5-nucleotidase

16

____ converts guanosine to guanine

Purine nucleoside phosphorylase (PNP)

17

_____ converts inosine to hypoxanthine

Purine nucleoside phosphorylase (PNP)

18

In the kidney, glutamine is converted to ____ and ____ by glutaminase, in the intestine, glutamine is used for ______

Glutamate NH3
Energy

19

In a normal healthy individual, amino acid is supplied in 3 sources:

Dietary protein
Glucose
Body protein

20

Amino acid is depleted when its carbon skeleton is used for ____, to make body protein, its also depleted by compounds that need ___

Energy
Nitrogen

21

Synthesis of urea occurs in 4 stages
1.
2.
3.
4. Urea cycle

Transamination
Oxidative deamination
Transport of ammonia

22

Removal of _____ is an obligatory step in oxidative degradation of amino acids

Amino group

23

Under starvation, urea production is ____

Increased

24

Carbamoyl phosphate synthetase converts _______ to carbmoyl phosphate

Ammonia+Co2+ATP

25

Carbamoyl phosphate synthetase is activated by _______, which is activated by argnine

N-acetylglutamate

26

_____ provides nitrogen in the urea cycle

NH3
Aspartate