Metabolic Regulation Flashcards Preview

Biochemistry 2 > Metabolic Regulation > Flashcards

Flashcards in Metabolic Regulation Deck (28):
0

Somatostatin inhibit the release of

Growth hormone
Insulin
Glucagon
Thyroid hormone

1

Site of pro glucagon synthesis include

Alpha cell of islet of Langerhans in the pancreas
L-cells if the intestine

2

Somatostatin is used in treatment of secretory neoplasm such as _____ of pituitary and associated gigantism or _____

GH-secreting tumor
Acromegaly

3

Insulin suppress glucagon release from pancreatic a-cell through ____ function

Paracrine

4

Counter regulatory hormone often specifically refers to hormones that oppose action of ______

Insulin

5

Counter regulatory hormone raise blood glucose level by promoting ______, ____ , and ______

Glycogenolysis
Gluconeogensis
Ketogenesis

6

Counter regulatory hormone that oppose the action of insulin includes ______

Glucagon
Growth hormone
Catecholamines
Glucocorticoid

7

Glucagon promotes Glycogenolysis
Gluconeogensis Ketogenesis by generating _____ in target cell

cAMP

8

Somatostatin (SS-14), a cyclic peptide, is produced from the _____

Preprosomatostatin

9

Prosomatostatin (SS-28) is seen in _____ and is 7-10 times more potent than ______

Gut
Somatostatin (SS-14)

10

Growth hormone is secreted by ____ cells in the anterior pituitary

Somatotroph

11

____ stimulates and ______ inhibits the release of growth hormone from the anterior pituitary

GHRH
Somatostatin

12

IGF-1 inhibits ________ release and stimulates _____ release

GHRH
Somatostatin

13

GHRH and somatostatin is released from ______

Hypothalamus

14

GH increases the availability of fatty acids for _____, and decreases the oxidation of ____ and ____

Oxidation
Glucose amino acids

15

GH decreases ______ esterification in _____ tissue

Fatty acid
Adipose

16

Free fatty acid and glycerol are released into the blood to be metabolized by the ____

Liver

17

GH increase the sensitivity of the adipocyte to _____ action of catecholamine and decrease its sensitivity to the ____ action of insulin.

Lipolytic
Lipogenic

18

In liver, IGF-1 increases ___ up takes and initiates cell propagation

Thymidine

19

IGF-1 is more potent than ____ in growth promoting action

Insulin

20

During fasting state, GH enhances hepatic _______ , leading to increased level of acetyl-coA

Fatty acid oxidation

21

____ is the precursor for catecholamines

Tyrosine

22

Norepinephrine is synthesized in adrenal _____ and various area of the ___ and in ____ nerve endings

Medulla
CNS
Adrenergic

23

The major function of catecholamines is to facilitate the body to adapt to _________

Acute and chronic stress

24

Thyroid hormone amplifies the ___ action of epinephrine and increase ____ release to liver

Lipolytic
Glycerol

25

Thyroid hormone increase the conversion of cholesterol to ____

Bike salt

26

Thyroid hormone increase ____ uptake by the muscle

Glucose

27

T3 is more active than ____, T4 can be converted to T3 by ____

T4
Deiodination