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Flashcards in Integration Of Fuel Metabolism Deck (18):
0

In the conversion of G-6-P to glycogen, the key regulatory enzyme is _____

Glycogen synthase

1

Glycogen synthase is activated by the ________ that occurs when insulin is ____ and glucagon is _____

Dephosphorylation
Elevated
Decreased

2

Glucokinase is a liver enzyme that has a High Km for ______

Glucose

3

Glycolysis is needed for both ____ production and ___ synthesis

Energy
TG

4

Reduced energy consumption increases level of ______ and decrease the level of ____ , slowing down citric acid cycle

NADH
ADP

5

Increased cytosolic _____ promotes synthesis of fatty acid and cholesterol

Acetyl-coA

6

LPL in adipose tissue has higher _____ than those in muscle, and is most active in ___ state

Km
Fed

7

_____ stimulates the secretion of LPL from adipose tissue

Insulin

8

The ___ tissue cannot utilize the glycerol derived from TG as it lacks ______

Adipose
Glycerol kinase

9

In fed state, insulin increase the number of glucose transporter in _______, promoting absorption of glucose

Adipocyte

10

The oxidation of glucose in adipocyte produces the energy and ___ for TG synthesis

Glycerol 3-phosphate

11

High NADH/NAD+ ratio diverts oxaloacetate into ____ to exit mitochondria and participate in _____

Malate
Gluconeogensis

12

High ____ level inhibits isocitrate dehydrogenase, leading to citrate accumulation and product inhibition of citrate synthase

NADH

13

As blood glucose drops, insulin level ____, the number of _____ transporter in the muscle plasma membrane is reduced, leading to reduced glucose uptake

Decrease
Glut4

14

Low level of ____ causes activation of CPTI

Malonyl-coA

15

During fasting, as blood insulin level fall and glucagon level rise, the level of cAMP _____ in adipose cells, consequently, protein kinase A is activated and cause phosphorylation of _____

Increases
Hormone sensitive lipase (HSL)

16

Glucokinase is a liver enzyme that has high Km for _____, because of the enzyme's ___ affinity for glucose, the enzyme is most active in fed state.

Glucose
Low

17

The lipoprotein triacylglycerols in chylomicron and VLDL are hydrolyzed to fatty acid and glycerol by _____

Lipoprotein lipase (LPL)