Cholinergic/ Parasympathetic

Question 1

Acetylcholine

Answer 1

prototype

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

Question 2

bethanechol

Answer 2

not hydrolyzed by AChE

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

Question 3

carbachol

Answer 3

not hydrolyzed by AChE

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

Question 4

methacholine

Answer 4

tx for asthma before

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

Question 5

pilocarpine

Answer 5

DOC for emergency lowering of intraoccular pressure

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

Question 6

arecoline

Answer 6

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

Question 7

muscarine

Answer 7

from mushrooms

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

Question 8

edrophonium

Answer 8

Tensilon
prototype
dx for myasthenia gravis

quaternary amine - short duration
indirect acting cholinergic agonist
parasympathetic effect

Question 9

physostigmine

Answer 9

antidote for anti-ACh poisoning (atropine, phenothiazene, TCA)

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

Question 10

neostigmine

Answer 10

antidote for tubocurarine poisoning

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

Question 11

pyridostigmine

Answer 11

Mestinon

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

Question 12

carbamate insecticides

Answer 12

carbacyl, methylcarbamate

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

Question 13

isoflurophate

Answer 13

tx for glaucoma

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 14

echothiphate

Answer 14

tx for glaucoma

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 15

malathion

Answer 15

pesticide

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 16

parathion

Answer 16

pesticide

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 17

tabun

Answer 17

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 18

sarin

Answer 18

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 19

soman

Answer 19

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

Question 20

atropine

Answer 20

prototype
active isomer: L-hyoscyamine

muscarinic blocker
cholinergic antagonist
sympathetic effect

Question 21

scopolamine

Answer 21

aka hyoscine
Buscopan
CI: pregnancy

muscarinic blocker
cholinergic antagonist
sympathetic effect

Question 22

homatropine

Answer 22

muscarinic blocker
cholinergic antagonist
sympathetic effect

Question 23

cyclopentolate

Answer 23

muscarinic blocker
cholinergic antagonist
sympathetic effect

Question 24

tropicamide

Answer 24

muscarinic blocker
cholinergic antagonist
sympathetic effect

Question 25

ipratropium

Answer 25

muscarinic blocker (M3 lungs) cholinergic antagonist sympathetic effect

Question 26

tiotropium

Answer 26

muscarinic blocker (M3 lungs) cholinergic antagonist sympathetic effect

Question 27

pirenprizine

Answer 27

tx for peptic ulcer muscarinic blocker cholinergic antagonist sympathetic effect

Question 28

benztropine

Answer 28

tx for parkinsons muscarinic blocker cholinergic antagonist sympathetic effect

Question 29

trihexyphenidyl

Answer 29

tx for parkinsons muscarinic blocker cholinergic antagonist sympathetic effect

Question 30

biperiden

Answer 30

tx for parkinsons muscarinic blocker cholinergic antagonist sympathetic effect

Question 31

darifenacin

Answer 31

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 32

fesoterodine

Answer 32

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 33

oxybutynin

Answer 33

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 34

solifenacin

Answer 34

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 35

tolterodine

Answer 35

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 36

trospium chloride

Answer 36

tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 37

other muscarinic blockers:

Answer 37

antihistamines, antipsychotics, TCA tx for overactive bladder muscarinic blocker cholinergic antagonist sympathetic effect

Question 38

nicotine

Answer 38

stimulate then block ganglionic blocker cholinergic antagonist sympathetic effect

Question 39

hexamethonium

Answer 39

block w/out prior stimulation ganglionic blocker cholinergic antagonist sympathetic effect

Question 40

mecamylamine

Answer 40

block w/out prior stimulation ganglionic blocker cholinergic antagonist sympathetic effect

Question 41

trimethaphan

Answer 41

block w/out prior stimulation ganglionic blocker cholinergic antagonist sympathetic effect

Question 42

lobeline

Answer 42

ganglionic blocker cholinergic antagonist sympathetic effect

Question 43

tubocurarine

Answer 43

isoquinoline: atracurium, tubocurarine steroidal: pancuronium, rocuronium low dose: competitive block receptor high dose: block ion channel non depolarizing, competitive, reversible neuromuscular blocker cholinergic antagonist sympathetic effect

Question 44

succinylcholine

Answer 44

contract then rest depolarizing, irreversible, non-competitive neuromuscular blocker cholinergic antagonist sympathetic effect