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MOD 4 - Pharmacology > CNS - Parkinsons & Opioids > Flashcards

CNS - Parkinsons & Opioids Flashcards

1
Q

carbidopa

A

Cinemet
DOPA decarboxylase inh

DOPA decarboxylase - degrades L-Dopa in periphery
anti-parkinsonism

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2
Q

entacapone

A

catechol o methyl transferase (COMT) inh

COMT - degrades L-Dopa in periphery

antiparkinsonism

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3
Q

tolcapone

A

catechol o methyl transferase (COMT) inh

COMT - degrades L-Dopa in periphery & brain

antiparkinsonism

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4
Q

selegiline

A

mao-b inh
mao b = degrades dopamine in brain

antiparkinsonism

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5
Q

rasagiline

A

mao-b inh
mao b = degrades dopamine in brain

antiparkinsonism

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6
Q

pramipexole

A

dopaminergic agonist
antiparkinsonism

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7
Q

ropinirole

A

dopaminergic agonist
antiparkinsonism

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8
Q

bromocriptine

A

dopaminergic agonist
antiparkinsonism

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9
Q

pergolide

A

dopaminergic agonist
antiparkinsonism

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10
Q

amantadine

A

Symmetrel (antiviral)
release dopamine in unaffected neurons

s/e: livedo reticularis (purple rash)

antiparkinsonism

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11
Q

benztropine

A

Cogentin
centrally acting anticholinergic
dec Ach = no contraction of Nm

antiparkinsonism

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12
Q

receptor for psychomimetic effects of opioid

A

kappa

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13
Q

receptor for ddiction/dependence a of opioid

A

mu

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14
Q

receptor for sedation of opioid

A

kappa

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15
Q

receptor for euphoria of opioid

A

mu

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16
Q

receptor for hallucinations of opioid

A

sigma

17
Q

opioid moa

A

dec camp (looks like a2)

18
Q

morphine

A

strong/full agonist
opioid

19
Q

methadone

A

strong/full agonist
opioid

20
Q

meperidine

A

strong/full agonist
opioid

21
Q

fentanyl

A

short acting but more potent than morphine

strong/full agonist
opioid

22
Q

codeine

A

dextrometorphan

moderate/partial agonist
opioid

23
Q

oxycodone

A

hydrocodone

moderate/partial agonist
opioid

24
Q

propoxyphene

A

weak agonist
opioid

25
Q

tramadol

A

weakest agonist/dual acting

26
Q

buprenorphine

A

mixed agonist-antagonist
opioid

27
Q

nalbuphine

A

mixed agonist-antagonist
opioid

28
Q

naloxone

A

antidote for morphine overdose

antagonist
opioid

29
Q

naltrexone

A

antagonist
opioid

30
Q

to avoid opioid overdose

A

give mixed agonist-antagonist
NOT tapered dose

31
Q

withdrawal timeline: physical symptoms at peak

A

72 hours

32
Q

withdrawal timeline: physical symptoms start to lessen

A

1 week

33
Q

withdrawal timeline: psychological and emotional symptoms

A

2 weeks

34
Q

withdrawal timeline: cravings and depression

A

1 month

MOD 4 - Pharmacology (19 decks)

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