Classic Labs/Findings Flashcards Preview

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Flashcards in Classic Labs/Findings Deck (35):
1

Anticentromere antibodies

Scleroderma (CREST)

2

Anti-desmoglein (epithelial) antibodies

Pemphigus vulgaris (blistering)

3

Anti-glomerular basement membrane antibodies

Goodpasture syndrome (glomerulonephritis and hemoptysis)

4

Antihistone antibodies

Druge induced SLE (hydralazine, isoniazid, phenytoin, procainamide)

5

Anti-IgG antibodies

Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity)

6

Antimitochondrial antibodies

1° biliary cirrhosis (female, cholestasis, portal hypertension)

7

Antineutrophil cytoplasmic antibodies (ANCAs)

Microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (MPO-ANCA/p-ANCA)
Granulomatosis with polyangiitis (Wegener; PR3-ANCA/c-ANCA)

8

Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)

SLE (type III hypersensitivity)

9

Antiplatelet antibodies

Idiopathic thrombocytopenic purpura

10

Anti-topoisomerase antibodies

Diffuse systemic Scleroderma

11

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

Celiac disease (diarrhea, weight loss)

12

"Apple core" lesion on barium enema x-ray

colorectal cancer (usually left-sided)

13

Atypical lymphocytes

EBV

14

Azurophilic peroxidase +, granular inclusions in granulocytes and myeloblasts

Auer rods (AML, especially promyelocytic M3 type)

15

Bacitracin response

Sensitive: S. pyogenes (group A)
Resistant: S. agalactiae (Group B)

16

Bamboo spine on X-ray

Ankylosing spondylitis (chronic inflammatory arthritis HLA-B27)

17

Basophilic nuclear remnants in RBC's

Howell-Jolly bodies (splenectomy or non-functional spleen)

18

Basophilic stippling of RBC's

Lead poisoning or sideroblastic anemia

19

Bloody or yellow tap on lumbar puncture

Subarachnoid hemorrhage

20

Boot-shaped heart on X-ray

Tetralogy of Fallot (due to RVH)

21

Branching gram-positive rods with sulfure granules

Actinomyces israelii

22

Bronchogenic apical lung tumor on imaging

Pancoast tumor (can compress sympathetic chain and cause Horner syndrome)

23

"Brown" tumor of bone

Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

24

Cardiomegaly with apical atrophy

Chagas disease (Trypanosoma cruzi)

25

Cellular crescents around Bowman capsule

Rapidly progressive crescentic glomerulonephritis

26

Chocolate cyst of ovary

Endometriosis (frequently both ovaries)

27

Circular grouping of dark tumor cells surrounding pale neurofibrils

Homer-Wright rosettes (neuroblastoma, medulloblastoma)

28

Colonies of mucoid Pseudomonas in lungs

Cystic fibrosis (Autosomal recessive CFTR mutation -->fat soluble vitamin deficiency and mucous plugs)

29

Decreased AFP in amniotic fluid/maternal serum

Down syndrome or other chromosomal abnormalities

30

Degeneration of dorsal column fibers

Tabes dorsalis (3° syphilis), subacute combined degeneration (dorsal columns, lateral corticospinal, spinocerebellar tracts affected)

31

"Delta wave" on EKG, short PR interval, supraventricular tachycardia

Wolf-Parkinson-White syndrome (Bundle of Kent bypasses AV node)

32

Depigmentation of neurons in substantia nigra

Parkinson disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)

33

Desquamated epithelium casts in sputum

Curschmann spirals (bronchial asthma, can result in whorled mucous plugs)

34

Disarrayed granulosa cells arranged around collections of eosinophilic fluid

Call-Exner bodies (granulosa cell tumor of the ovary)

35

Dysplastic squamous cervical cells with "raisinoid" nuclei and hyperchromasia?

Koilocytes (HPV: predisposes to cervical cancer)