Classic Labs/Findings III Flashcards Preview

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Flashcards in Classic Labs/Findings III Deck (29):
1

Low serum ceruloplasmin

Wilson disease (hepatolenticular degenration)

2

"Lumpy bumpy" appearance of glomeruli on immunofluorescence

Poststreptococcal glomerulonephritis (due to deposition of IgG, IgM, and C3)

3

Lytic ("punched out") bone lesions on x-ray

Multiple myeloma

4

Mammary gland ("blue domed") cyst

Fibrocystic change of the breast

5

Monoclonal antibody spike

Multiple myeloma (usually IgG or IgA)
Monoclonal gammopathy of undetermined significance (consequence of aging)
Waldenstrom (M protein = IgM) macroglobulinemia
Primary amyloidosis

6

Mucin-filled cell with peripheral nucleus

"Signet ring" (gastric carcinoma)

7

Narrowing of bowel lumen on barium X-ray

"String sign" (Crohn's disease)

8

Nodular hyaline deposits in glomeruli

Kimmelsteil-Wilson nodules (diabetic nephropathy)

9

Necrotizing vasculitis (lungs) and necrotising glomerulonephritis

Granulomatous with polyangiitis (Wegener, Pr3-ANCA and c-ANCA)
Goodpasture syndrome (anti-basement membrane antibodies)

10

Needle-shaped, negatively birefringent crystals

Gout (monosodium urate crystals)

11

Novobiocin response

Sensitive: Staph epidermidis
Resistant: Staph saprophyticus

12

Nutmeg appearance of liver

Chronic passive congestion of liver due to right heart failure or Budd Chiari syndrome

13

Optochin response

Sensitive: Strep pneumoniae
Resistant: Strep viridans (mutans, sanguis)

14

Onion skin periosteal reaction

Ewing sarcoma (malignant small blue cell tumor)

15

Periosteum raised from bone, creating triangular area

Codman triangle on x-ray, Ewing sarcoma, pyogenic osteomyelitis

16

Podocyte fusion or effacement on electron microscopy

Minimal change disease (child with nephrotic syndrome)

17

Polished, ivory-like appearance of bone at cartilage erosion

Eburnation (osteoarthritis resulting in bony sclerosis)

18

Protein aggregates in neurons from hyperphosphrylation of tau protein

Neurofibrillary tangles (Alzheimer disease) and Pick bodies (Pick disease)

19

Psammomma bodies

Meningiomas
Papillary thyroid carcinoma
Mesothelioma
Papillary serous carcinoma of endometrium and ovary

20

Pseudopalisading tumor cells on brain biopsy

Glioblastoma multiforme

21

RBC casts in urine

Glomerulonephritis

22

Rectangular crystal-like, cytoplasmic inclusions in Leydig Cells

Reinke crystals (Leydig cell tumor)

23

Recurrent infections, eczema, thrombocytopenia

Wiskott-Aldrich syndrome

24

Renal epithelial casts in urine

Intrinsic renal failure (e.g., ischemia or toxic injury)

25

Rhomboid crystals, positively birefringent

Pseudogout (calcium pyrophosphate dihydrate crystals)

26

Rib notching

Coarctation of the aorta

27

Ring-enhancing brain lesions in AIDS

Toxoplasma gondii, CNS lymphoma

28

Sheets of medium-sized lymphoid cells with scattered pale, tingible body-laden macrophages ("starry sky" histology)

Burkitt lymphoma (t[8,14] c-myc activation associated with EBV; "starry sky" made up of malignant cells)

29

Silver-staining spherical aggregation of tau proteins in neurons

Pick bodies (Pick disease: progressive dementia, changes in personality