Classic Presentations IV Flashcards Preview

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Flashcards in Classic Presentations IV Deck (28):
1

Painless erythematous lesions on palms and soles

Janeway lesions (infective endocarditis, septic emboli/microabscesses)

2

Painless jaundice

Cancer of the pancreatic head obstructing bile duct

3

Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria

Henoch-Schonlein purpura (IgA vasculitis affecting skin and kidneys)

4

Pancreatic, pituitary, parathyroid tumors

MEN 1 (autosomal dominant)

5

Periorbital and/or peripheral edema, proteinuria, hypoabuminemia, hypercholestrolemia

Nephrotic syndrome

6

Pink complexion, dyspnea, hyperventilation

"Pink puffer" (emphysema: centriacinar [smoking], panacinar [alpha-1-antitrypsin deficiency])

7

Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances, hypophosphatemic rickets

Fanconi syndrome (multiple combined dysfunction of the proximal convoluted tubule)

8

Puritic, purple, polygonal planar papules and plaques

Lichen planus

9

Ptosis, miosis, anhidrosis

Horner syndrome (sympathetic chain lesion)

10

Pupil accommodates but doesn't react

Argyll Robertson pupil (neurosyphilis)

11

Rapidly progressive limb weakness that ascends following GI/upper respiratory infection

Guillain-Barre syndrome (acute inflammatory demylinating polyradiculopathy subtype)

12

Rash on palms and soles

Coxsackie A, 2° syphilis, Rocky Mountain spotted fever

13

Recurrent cold (noninflamed) abscesses, unusual eczema, high serum IgE

Hyper-IgE syndrome (Job syndrome: Neutrophil chemotaxis abnormality)

14

Red "currant jelly" sputum in alcoholic or diabetic patients

Klebsiella pneumoniae pneumonia

15

Red "currant jelly" stools

Acute mesenteric ischemia (adults), intussusception

16

Red, itchy, swollen rash of nipple/areola

Paget disease of breast (Sign of underlying neoplasm)

17

Red urine in the morning, fragile RBC's

Paroxysmal nocturnal hemoglobinuria

18

Renal cell carcinoma (bilateral) hemangioblastomas, angiomatosis, pheochromocytoma

von Hippel Lindau disease (dominant tumor suppressor gene mutation)

19

Resting tumor, rigidity, akinesia, postural instability, shuffling gate

Parkinson disease (loss of dopaminergic neurons in substantia nigra pars compacta)

20

Retinal hemorrhages with pale centers

Roth spots (bacterial endocarditis)

21

Severe jaundice in neonate

Crigler-Najjar syndrome (congenital unconjugated hyperbilirubinemia)

22

Severe RLQ pain with palpation of LLQ

Rovsing sign (acute appendicitis)

23

Severe RLQ pain with rebound tenderness

McBurney sign (acute appendicitis)

24

Short stature, cafe au lait spots, thumb/radial defects, increased incidence of tumors/leukemia, aplastic anemia

Fanconi anemia (genetic loss of DNA crosslink repair; often progresses to AML)

25

Single palmar crease

Down syndrome

26

Situs inversus, Chronic sinusitis, bronchiectasis, infertility

Zach Fredman syndrome
But really Kartagener syndrome (dynein arm defect affecting cilia)

27

Skin hyperpigmentation, hypotension, fatigue

1° adrenocortical insufficiency ([e.g. Addison disease] causes increased ACTH and increased alpha-MSH production)

28

Slow, progressive muscle weakness in boys

Becker muscular dystrophy (X-linked missense mutation in dystrophin; less severe than Duchenne)