Flashcards in Clinical Correlation: Transplantation Deck (6):
what are the two kinds of transplant surgery and examples of each?
-heterotopic: kidney, pancreas
-orthotopic:lung, liver, kidney
Describe: Induction therapy vs. maintenance therapy:
-monoclonal Ab or polyclonal Ab or none: basiliximab or thymoglobulin
-higher doses of maintenance agents
-primary agent: calcineurin inhibitor: tacrolimus or cyclosporine
-antiproliferative agent: mycophenolic acid or azathioprine or sirolimus
List the means of monitoring a patient post-tx:
-tests of funx : pulmonary funx, serum creatinine
-signs of organ damage: enzymes
-imaging of organ
-tissue examination: biopsy
what are the common findings in chronic allograft disease?
-obliterative arteriopathy (loos of blood vessels)
What diseases/conditions are tx patients at higher risk for?
-renal failure (non-renal tx)
-bone disease: osteopenia nand osteoporosis, avascular necrosis
-reproduction (note: some immunosuppressives are teratogenic)