Clinical Correlation: Transplantation Flashcards Preview

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Flashcards in Clinical Correlation: Transplantation Deck (6):
1

what are the two kinds of transplant surgery and examples of each?

-heterotopic: kidney, pancreas

-orthotopic:lung, liver, kidney

2

Describe: Induction therapy vs. maintenance therapy:

induction therapy:
-monoclonal Ab or polyclonal Ab or none: basiliximab or thymoglobulin
-higher doses of maintenance agents

maintenance therapy:
-primary agent: calcineurin inhibitor: tacrolimus or cyclosporine
-antiproliferative agent: mycophenolic acid or azathioprine or sirolimus
-steroids

3

List the means of monitoring a patient post-tx:

-immunosuppression
-tests of funx : pulmonary funx, serum creatinine
-signs of organ damage: enzymes
-imaging of organ
-tissue examination: biopsy

4

what are the common findings in chronic allograft disease?

-interstitial fibrosis
-parencyhmal atrophy
-obliterative arteriopathy (loos of blood vessels)

5

What diseases/conditions are tx patients at higher risk for?

-malignancy
-metabolic disease
-renal failure (non-renal tx)
-bone disease: osteopenia nand osteoporosis, avascular necrosis
-reproduction (note: some immunosuppressives are teratogenic)

6

complications of tx include:

-acute rejection
-chronic graft dysfunction
-infection
-malignancy
-medical complications