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Flashcards in Immunocompromise II Deck (8):

Late Component Complement Deficiency (LCCD) results from deficiency of any of the following: C5-C9. What are its characteristics?

-incs risk of meningococcal infx 5000 to 10,000 fold
-age of onset of meningococcal infx is much later in LCCD (17 yo vs 5 yo)
-serogroups causing meningicoccal disease in pts with LCCD are uncommon
-50% pts with LCCD get recurrent infx
-mortality from meningococcal disease in LCCD is 1/10 of that in general population -vaccination against meningococcus benefits these pts


Neutrophil deficits (quantity/quality) result in infx from our own microbiome. What pathogens cause the most common infectious complications from deficits in neutrophils?

-gram-negative bacteria


what is the main complication for neutropoenia versus neutrophil dysfunction?

-neutropoenia: sepsis

-neutrophil dysfunction:localized dysfunction


Neutropoenia results in increased risk for infection dur to which two road groups of pathogens?

-aspergillus (environmental fungus)


What is a complication of chemotherapy-induced neutropoenia?

-Febrile Neutropoenia (FNP)


How does chemotherapy impact primary defenses (weaken them)?

-disrupted mucosal barriers: gram negative bacilli cause GI infx
-venous catheters cause skin organisms to enter (gram positive cocci)
-broad spectrum antibiotics --> fungi become more dangerous in later FNP


Recovery of neutrophil count can result in what 2 major immune reconstitution syndromes?

-asymptomatic pulmonary infiltrates
-hepatosplenic candidiasis (granulomatous response)


What infections are hospitalized patients at greater risk of developing?

-bacteroemia (due to venous catheters)
-hospital-acquired MRSA and VRE
-surgical site infections