Flashcards in Sepsis Deck (10):
What is SIRS?
How is it defined?
Systemic Inflammatory Response Syndrome
>= 2 of :
-temp >38 or 90bpm
-RR>20/min or PaCO2 12000 cells/mm^3 or 10% immature (band) forms
What are the causes of SIRS?
-non-infectious causes of SIRS:
What is sepsis?
SIRS (severe inflammatory response syndrome) due to proven/probable infection.
Define severe sepsis
Define severe shock
1. Severe sepsis:
-hypotension (syst bp 40 from baseline)
-hypoperfusion (lactic acidosis)
2. Septic shock:
-severe sepsis with hypotension that doesn't respond to fluid resuscitation and requires pressors
List the following in order of increasing disease severity:
infection, sepsis, septic shock, severe sepsis, SIRS
Explain the 'stranger-danger' principle:
danger=DAMPs (cell death)
--> bind TLRs (innate cells)--> activates:
What effects to cytokines have?
-increase vascular permeability
-increased local blood flow
-infiltration of PMNs, compliment, antibacterial proteins
= Sx of inflammation (redness, warmth, pain)
What anti-inflammatory cytokines help keep the immune response local and controlled?
What cytokine agonists aid in anti-inflammation?
What antiinflmmatory hormones are released?
How do you treat sepsis?
1. broad-spectrum antibiotics
2. source control