Herpesviridae Virology Flashcards Preview

Immunology > Herpesviridae Virology > Flashcards

Flashcards in Herpesviridae Virology Deck (17):
1

What is Herpesviridae?

dsDNA virus with an envelope; 8 herpesviruses known

*replication in nucleus of infected cell (episomal ie DNA not incorporated to host genome)

2

What two types of infection do herpes viruses cause?

lytic and latent infection

3

What cells are infected by the following members of the herpesviridae family?

HSV 1,2, VZV
CMV, HHV6
HHV-7
EBV
HHV-8

HSV 1,2, VZV: sensory and cranial nerve ganglia

CMV, HHV6: monocytes, macrophages, CD34+ cells

HHV-7: CD4+ cells (helper)

EBV: Memory B cells (mono)

HHV-8: B cells

4

What are precipitating factors for herpes reactivation?

sunlight
fever
local trauma
menstruation
emotional stress

5

What antivirals are used to treat Herpes?

acyclovir, famiclovir, valacyclovir

*impact shedding and duration of sores

6

What 3 conditions are a result of infection with VZV?

-chickenpox
-Zoster (shingles)
-Congenital Varicella (v uncommon)

7

What is the rx for VZV?

- if chickenpox in healthy kid, nothing

-severe disease in immune compromised people: acyclovir

8

What are the preventative measures for VZV infection?

-VZIG (immune globulin, 96 hrs pre-exposure at least)

-Varicella (chickenpox) vacine.
-Zoster (shingles) vaccine- to keep latent

9

What condition does HHV-6 cause?

Roseola infantum: fever 3-4 d, resolves then get rash

often Asx

10

What disease does EBV cause most often?

-in childhood mostly Asx

-Mono in adultes/teens: fever, lymphadenopathy, fatigue, sore throat, hepatosplenomegaly, atypical lymphocytes

-associated with 'Burkitt's Lymphoma' AND nasopharyngeal carcinoma

**oncovirus

11

How is EBV infection diagnosed and treated?

-Monospot (heterophile Ab) SEROLOGY

-supportive rx, protect spleen, no vaccine

12

What disease does CMV cause?

-mono-like illness, hepatitis, Asx (usually)

-severe illness in : AIDS, Tx, Neonates

13

What condition cause CMV cause in neonates?

CID- cytomegalic inclusion disease : jaundice, hepatosplenomegaly, petechial rash, microcephaly, cerebral calcifications, chorioretinitis

14

Who is treated for CMV and what is the treatment of choice?

only immunocompromised patients are treated for CMV inection.

Ganciclovir, Foscarnet

15

What is the alternative name for HHV-8?

Kaposi's Sarcoma-Associated Herpesvirus (KSHV)

16

What does HHV-8 infection cause in healthy versus immunocompromised people?

healthy: febrile exanthem, mono?

immune compromised: Kaposi's sarcoma, Castleman's disease, Primary effusion lymphoma

17

How is Kaposi's Sarcoma diagnosed?

-skin lesion biopsy...

usually seen in HIV positive individuals (90-100% KS in HIV+)