Flashcards in Herpesviridae Virology Deck (17):
What is Herpesviridae?
dsDNA virus with an envelope; 8 herpesviruses known
*replication in nucleus of infected cell (episomal ie DNA not incorporated to host genome)
What two types of infection do herpes viruses cause?
lytic and latent infection
What cells are infected by the following members of the herpesviridae family?
HSV 1,2, VZV
HSV 1,2, VZV: sensory and cranial nerve ganglia
CMV, HHV6: monocytes, macrophages, CD34+ cells
HHV-7: CD4+ cells (helper)
EBV: Memory B cells (mono)
HHV-8: B cells
What are precipitating factors for herpes reactivation?
What antivirals are used to treat Herpes?
acyclovir, famiclovir, valacyclovir
*impact shedding and duration of sores
What 3 conditions are a result of infection with VZV?
-Congenital Varicella (v uncommon)
What is the rx for VZV?
- if chickenpox in healthy kid, nothing
-severe disease in immune compromised people: acyclovir
What are the preventative measures for VZV infection?
-VZIG (immune globulin, 96 hrs pre-exposure at least)
-Varicella (chickenpox) vacine.
-Zoster (shingles) vaccine- to keep latent
What condition does HHV-6 cause?
Roseola infantum: fever 3-4 d, resolves then get rash
What disease does EBV cause most often?
-in childhood mostly Asx
-Mono in adultes/teens: fever, lymphadenopathy, fatigue, sore throat, hepatosplenomegaly, atypical lymphocytes
-associated with 'Burkitt's Lymphoma' AND nasopharyngeal carcinoma
How is EBV infection diagnosed and treated?
-Monospot (heterophile Ab) SEROLOGY
-supportive rx, protect spleen, no vaccine
What disease does CMV cause?
-mono-like illness, hepatitis, Asx (usually)
-severe illness in : AIDS, Tx, Neonates
What condition cause CMV cause in neonates?
CID- cytomegalic inclusion disease : jaundice, hepatosplenomegaly, petechial rash, microcephaly, cerebral calcifications, chorioretinitis
Who is treated for CMV and what is the treatment of choice?
only immunocompromised patients are treated for CMV inection.
What is the alternative name for HHV-8?
Kaposi's Sarcoma-Associated Herpesvirus (KSHV)
What does HHV-8 infection cause in healthy versus immunocompromised people?
healthy: febrile exanthem, mono?
immune compromised: Kaposi's sarcoma, Castleman's disease, Primary effusion lymphoma