Clozapine (Clozaril)

Question 1

What is the brand name of Clozapine?

Answer 1

Clozaril

Question 2

What type of medication is Clozapine?

Answer 2

Antipsychotic

Question 3

What is the primary action of Clozapine?

Answer 3

It acts as an antagonist at dopamine D2 receptors and has effects on serotonin receptors.

Question 4

What is Clozapine primarily indicated for?

Answer 4

Treatment-resistant schizophrenia.

Question 5

True or False: Clozapine can be used to treat anxiety disorders.

Answer 5

False

Question 6

What is a major adverse effect of Clozapine?

Answer 6

Agranulocytosis

Question 7

Fill in the blank: Clozapine should be used cautiously in patients with a history of _______.

Answer 7

bone marrow suppression

Question 8

What should be monitored regularly in patients taking Clozapine?

Answer 8

White blood cell count

Question 9

True or False: Clozapine can cause seizures.

Answer 9

True

Question 10

What is a common side effect of Clozapine that affects weight?

Answer 10

Weight gain

Question 11

List one drug interaction that can occur with Clozapine.

Answer 11

Interactions with other CNS depressants.

Question 12

What is a contraindication for the use of Clozapine?

Answer 12

Hypersensitivity to Clozapine or other ingredients.

Question 13

What are the nursing considerations for a patient starting Clozapine?

Answer 13

Monitor for agranulocytosis and educate about signs of infection.

Question 14

True or False: Clozapine can be prescribed for bipolar disorder.

Answer 14

False

Question 15

What is the risk of myocarditis associated with Clozapine?

Answer 15

Increased risk of myocarditis and cardiomyopathy.

Question 16

What should patients be informed about regarding the risk of seizures with Clozapine?

Answer 16

Patients with a history of seizures are at higher risk.

Question 17

Fill in the blank: Clozapine is often used when other antipsychotics have _______.

Answer 17

failed

Question 18

What is the mechanism of action of Clozapine related to serotonin?

Answer 18

It antagonizes serotonin 5-HT2A receptors.

Question 19

True or False: Clozapine requires regular blood monitoring.

Answer 19

True

Question 20

What is the target ANC level for patients on Clozapine?

Answer 20

At least 1500 cells/mm³

Question 21

What is one important dietary consideration for patients on Clozapine?

Answer 21

Avoiding alcohol due to potential interactions.

Question 22

What is the main pharmacokinetic property of Clozapine?

Answer 22

It has a long half-life.

Question 23

List one symptom of agranulocytosis to watch for in patients taking Clozapine.

Answer 23

Fever or sore throat.

Question 24

What can happen if Clozapine is abruptly discontinued?

Answer 24

Withdrawal symptoms may occur.

Question 25

True or False: Clozapine can be used in elderly patients without caution.

Answer 25

False

Question 26

What is an important counseling point regarding Clozapine and smoking?

Answer 26

Smoking can decrease Clozapine levels.

Question 27

Fill in the blank: Clozapine is contraindicated in patients with _______ disorders.

Answer 27

severe cardiac

Question 28

What is the recommended starting dose for Clozapine?

Answer 28

25 mg once daily.

Question 29

How often should the white blood cell count be monitored during the first six months of Clozapine treatment?

Answer 29

Weekly.

Question 30

What is the maximum recommended dose of Clozapine per day?

Answer 30

900 mg.

Question 31

What is the potential effect of Clozapine on metabolic parameters?

Answer 31

It may cause metabolic syndrome.

Question 32

True or False: Clozapine has a lower risk of extrapyramidal symptoms compared to other antipsychotics.

Answer 32

True

Question 33

What serious condition can Clozapine potentially lead to that affects the heart?

Answer 33

Myocarditis

Question 34

What is the significance of Clozapine's black box warning?

Answer 34

It highlights the risk of agranulocytosis.

Question 35

What patient population should be particularly cautious when using Clozapine?

Answer 35

Patients with a history of seizures.

Question 36

What is the main reason for requiring a patient to enroll in a Clozapine registry?

Answer 36

To monitor for blood dyscrasias.

Question 37

Fill in the blank: Clozapine has been shown to reduce _______ in treatment-resistant schizophrenia.

Answer 37

suicidal behavior

Question 38

What is a potential effect of Clozapine on the gastrointestinal system?

Answer 38

Constipation