Valbenazine ( Ingrezza)

Question 1

What is the generic name of Ingrezza?

Answer 1

Valbenazine

Question 2

What is the primary action of Valbenazine?

Answer 2

Valbenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor.

Question 3

What condition is Valbenazine primarily indicated for?

Answer 3

Valbenazine is indicated for the treatment of tardive dyskinesia.

Question 4

True or False: Valbenazine can be used to treat schizophrenia.

Answer 4

False

Question 5

What is a common adverse effect of Valbenazine?

Answer 5

Somnolence (drowsiness) is a common adverse effect.

Question 6

Fill in the blank: Valbenazine is contraindicated in patients with a history of __________.

Answer 6

hypersensitivity to Valbenazine or any of its components.

Question 7

List one drug interaction that may occur with Valbenazine.

Answer 7

Valbenazine may interact with strong CYP3A4 inhibitors.

Question 8

What is the mechanism by which Valbenazine alleviates tardive dyskinesia symptoms?

Answer 8

By inhibiting VMAT2, Valbenazine decreases the release of dopamine.

Question 9

True or False: Valbenazine is safe to use during pregnancy.

Answer 9

False; the safety of Valbenazine during pregnancy has not been established.

Question 10

What is the recommended starting dose of Valbenazine?

Answer 10

The recommended starting dose is 40 mg once daily.

Question 11

What should be monitored in patients taking Valbenazine?

Answer 11

Patients should be monitored for signs of sedation or drowsiness.

Question 12

Fill in the blank: Valbenazine is primarily metabolized by the __________ enzyme.

Answer 12

CYP2D6

Question 13

What is the maximum recommended dose of Valbenazine?

Answer 13

The maximum recommended dose is 80 mg once daily.

Question 14

True or False: Valbenazine can be taken with or without food.

Answer 14

True

Question 15

What is an important consideration when prescribing Valbenazine to elderly patients?

Answer 15

Elderly patients may be more sensitive to the sedative effects.

Question 16

What type of patients should be cautioned when using Valbenazine?

Answer 16

Patients with a history of depression or suicidal thoughts.

Question 17

Fill in the blank: Valbenazine may increase the risk of __________ when used with other CNS depressants.

Answer 17

sedation

Question 18

What should be done if a patient misses a dose of Valbenazine?

Answer 18

The patient should take the missed dose as soon as they remember, but not if it is almost time for the next dose.

Question 19

True or False: Valbenazine is a first-line treatment for tardive dyskinesia.

Answer 19

True

Question 20

What is the significance of the VMAT2 inhibition by Valbenazine?

Answer 20

It reduces the release of dopamine, which helps to manage tardive dyskinesia symptoms.

Question 21

What is a rare but serious adverse effect of Valbenazine?

Answer 21

QT prolongation is a rare but serious adverse effect.

Question 22

Fill in the blank: Patients taking Valbenazine should avoid __________ due to potential interactions.

Answer 22

strong CYP3A4 inhibitors

Question 23

What is the pharmacological classification of Valbenazine?

Answer 23

Valbenazine is classified as an antipsychotic.

Question 24

True or False: Valbenazine can be used in combination with other antipsychotics.

Answer 24

True, but caution is advised due to potential interactions.

Question 25

What is the primary route of administration for Valbenazine?

Answer 25

Oral administration.

Question 26

What is an important counseling point for patients taking Valbenazine?

Answer 26

Patients should be advised not to drive or operate heavy machinery until they know how Valbenazine affects them.

Question 27

What should be done if a patient experiences severe side effects while on Valbenazine?

Answer 27

The patient should contact their healthcare provider immediately.

Question 28

Fill in the blank: Valbenazine is not recommended for use in patients with __________ disease.

Answer 28

severe hepatic

Question 29

What is the effect of Valbenazine on motor function in patients with tardive dyskinesia?

Answer 29

Valbenazine helps to improve motor function by reducing involuntary movements.

Question 30

True or False: Valbenazine can be abruptly discontinued without tapering.

Answer 30

False; discontinuation should be done gradually if possible.

Question 31

What is the typical duration of treatment with Valbenazine for tardive dyskinesia?

Answer 31

Treatment duration may vary but is often long-term.