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Nutrition > Cobalamin > Flashcards

Flashcards in Cobalamin Deck (21):
1

is it a trace element, vitamin, or mineral? Cobalamin

vitamin b12

2

what are its four properties? Cobalamin

high molecular weight, red cyrstalline, in complexes of animal protein, increases proteins biological value

3

whats the result of antibiotics in animals? Cobalamin

increases growth of animal by 15-20% by inhibiting growth of microorganisms that destroy b12

4

what are the first two steps of its unique absorption? Cobalamin

stomach: HCI & intrinsic factor --> binds to haptocorrin (R factor), a salivary glycoprotein

5

what is the third step of its unique absorption? Cobalamin

then split by protease and rebinds to intrinsic factor in duodenum of small intestine and carries to receptors in ileum where absorbed

6

what are the details of the first step of its unique absorption (stomach: HCI and Instrinsic factor)? Cobalamin

HCl acid splits off B12 from protein complexes in food and salivary
protein by denaturing it; proton inhibitor

7

what happens to the elderly in the absorption? Cobalamin

they may produce less acid;

8

what are the details of the second step of its unique absorption (binds to haptocorrin (R factor), a salivary glycoprotein)? Cobalamin

Protects from HCl acid of stomach as it moves through

9

Most deficiencies are due to what? Cobalamin

defects in absorption than diet defects

10

what are its two functions? Cobalamin

Coenzyme involved in transfer of methyl (-CH3) groups; General growth factor and anemia prevention

11

what are the details of its function as: Coenzyme involved in transfer of methyl (-CH3) groups? Cobalamin

Removes a methyl to activate the folate coenzyme (THF); Folate donates methyl to activate Vitamin B12

12

what are the details of its function as: General growth factor and anemia prevention? Cobalamin

Protein and fat metabolism, DNA formation

13

what are the three deficiency symptoms? Cobalamin

Pernicious anemia, Irreversible degeneration of nervous system, Abnormal blood lipids

14

what happens with the deficiency symptom of pernicious anemia? Cobalamin

fatigue

15

what happens with the deficiency symptom of Irreversible degeneration of nervous system? Cobalamin

High dose levels given in brain atrophy

16

what are the four things that can cause inadequate absorption? Cobalamin

Lack of hydrochloric acid or intrinsic factor, Partial or complete removal of stomach, Lack of blood protein that transport, Tapeworm, Elderly

17

what happens with deficiency due to a vegan diet? Cobalamin

May not exhibit anemia due to large intake of folates

18

what are 3 things that cause a deficiency? Cobalamin

Inadequate absorption, Vegan diets, Anemia of folate deficiency

19

how long can deficiency symptom take to appear? Cobalamin

3-6 yrs

20

whats the recommended daily intake? Cobalamin

2.4 micro grams

21

do most diets contain enough? Cobalamin

yes