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Flashcards in Thiamin Deck (46):
1

is it a trace element, vitamin, or mineral? Thiamin

vitamin B1

2

whats its coenzyme form?Thiamin

TPP, Thiamin Pyrophosphate

3

what quantities are stored in the body? Thiamin

30-70 mg

4

what is it easily destroyed by? Thiamin

heat or oxidation

5

what part of this is destroyed by what enzyme? Thiamin

Weak bridge, thaminase

6

what eight food sources is thaminase found in? Thiamin

tea, raw fish, clams, shrimp, mussels, fish paste, betel nut, fermented tea

7

what does it add to become active? Thiamin

two phosphate groups

8

what are its four functions? Thiamin

Carbohydrate metabolism, Maintenance of nervous system, Affects cardiovascular system, Normal appetite

9

in its function of carbohydrate metabolism what is an indicator of status? Thiamin

Level of enzyme, transketolase

10

what are the five deficiency symptoms related to its function of nervous system maintenance? Thiamin

-Neuritis -Irritability -Mental depression -Anorexia -Paresthesia

11

what happens in Paresthesia? Thiamin

neuritis

12

what is neuritis? Thiamin

inflammation of nerves

13

where does Carbohydrate metabolism take place? Thiamin

TCA cycle

14

what are the two deficiency symptoms in its function in the cardiovascular system? Thiamin

weak muscle, heart failure

15

at what level does normal appetite occur? Thiamin

Occurs >0.2 mg/1000 calories

16

how does it affect someones appetite? Thiamin

Does not increase appetite over normal

17

what disease did Takaki cure the Japanese navy of and how did he do it? Thiamin

less rice & more vegetables

18

what disease did Eijkman cure pigeons of and how did he do it? Thiamin

fed pigeons same diet as prisoners

19

what did Grijns suggest in relation to Beri Beri disease? Thiamin

rice have vital substance in hulls

20

what did Funk discover and what did he name it? Thiamin

isolated and named it vital amine

21

how many people suffer symptoms of Beri Beri disease? Thiamin

1.5 million

22

what are the three places where people can be especially prone to Beri Beri? Thiamin

 Countries where polished rice is a staple
 Victims of political trade embargos  Displaced persons in refugee camps

23

what are the three reasons people get Beri Beri? Thiamin

 Failure to enrich rice  Washing of rice
 Soaking of rice

24

whats going on with the Karentribe in relation to Beri Beri? Thiamin

Thailand-Burma border; Infantile mortality is major

25

who are the three groups of people that prone to get Beri Beri in the US? Thiamin

alcoholics, low carbohydrate diets, low carbohydrate diets + tea + raw fish

26

what are the three symptoms of Beri Beri? Thiamin

Neurological changes, Mental confusion, Cardiovascular failure

27

with the symptom of Mental confusion in Beri Beri what are the five things that can happen? Thiamin

Irritability, depression, headache, fear, coma

28

with the symptom of neurological changes what are the six things that can happen? Thiamin

 Muscle weakness and wasting
 CNS creates unsteady gait
 Peripheral neuritis
 Decreased speed and coordination  Paresthesia
 Constipation

29

with the symptom of neurological change in Beri Beri, Decreased speed and coordination is one of the things that can happen so what specifically happens with this? Thiamin

loss of knee/ankle jerk

30

with the symptom of neurological change in Beri Beri one of the things that can happen is constipation, what specifically happens here? Thiamin

decreased tonus of GI tract

31

what are the two different types of Beri Beri? Thiamin

infantile and adult

32

what are the three symptoms of infantile beri beri? Thiamin

Cyanosis, tachycardia, weak cry, convulsion

33

how long does infantile beri beri last and what can be a serious consequence? Thiamin

2-5 months, frequently fatal

34

who normally gets infantile beri beri? Thiamin

Often breast fed mother with low thiamin diet

35

what is cyanosis? Thiamin

symptom of infantile beri beri where blue lips occur

36

what is tachycardia? Thiamin

symptom of infantile beri beri where irregular heart beat occurs

37

what are the two different types of adult beri beri? Thiamin

Wet (Edematous), Dry (Wasting)

38

what are the two things that happens with adult Wet (Edematous) beri beri? Thiamin

 Swelling of limbs
 Accumulation of fluid in heart -> heart failure

39

what happens with dry (wasting) adult beri beri? Thiamin

Gradual loss of body tissues

40

what are the recommended requirements? Thiamin

 0.5 mg/1000 cal (minimum 1 mg for any caloric intake)  M 1.2 mg, F 1.1 mg

41

when are the two cases when you should increase your thiamin intake above the recommended amounts? Thiamin

 Pregnancy, growth, old age (problems in absorption)  Alcohol

42

what are the two reasons people who drink alcohol should increase their thiamin intake above the recommended amounts? Thiamin

 Thiamin necessary to breakdown to acetaldehyde
 Interferes with thiamin absorption

43

what is the one case where you should decrease your intake below the recommended amounts? Thiamin

High fat diet

44

why should a person with a high fat diet decrease their recommended level of this? Thiamin

Means low carbohydrates (need thiamin for
metabolism)

45

what is the toxicity symptoms? Thiamin

none known

46

what are the three main food sources? Thiamin

 Pork products  Whole grains  Enriched foods