Thiamin Flashcards

(46 cards)

1
Q

is it a trace element, vitamin, or mineral? Thiamin

A

vitamin B1

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2
Q

whats its coenzyme form?Thiamin

A

TPP, Thiamin Pyrophosphate

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3
Q

what quantities are stored in the body? Thiamin

A

30-70 mg

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4
Q

what is it easily destroyed by? Thiamin

A

heat or oxidation

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5
Q

what part of this is destroyed by what enzyme? Thiamin

A

Weak bridge, thaminase

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6
Q

what eight food sources is thaminase found in? Thiamin

A

tea, raw fish, clams, shrimp, mussels, fish paste, betel nut, fermented tea

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7
Q

what does it add to become active? Thiamin

A

two phosphate groups

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8
Q

what are its four functions? Thiamin

A

Carbohydrate metabolism, Maintenance of nervous system, Affects cardiovascular system, Normal appetite

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9
Q

in its function of carbohydrate metabolism what is an indicator of status? Thiamin

A

Level of enzyme, transketolase

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10
Q

what are the five deficiency symptoms related to its function of nervous system maintenance? Thiamin

A

-Neuritis -Irritability -Mental depression -Anorexia -Paresthesia

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11
Q

what happens in Paresthesia? Thiamin

A

neuritis

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12
Q

what is neuritis? Thiamin

A

inflammation of nerves

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13
Q

where does Carbohydrate metabolism take place? Thiamin

A

TCA cycle

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14
Q

what are the two deficiency symptoms in its function in the cardiovascular system? Thiamin

A

weak muscle, heart failure

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15
Q

at what level does normal appetite occur? Thiamin

A

Occurs >0.2 mg/1000 calories

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16
Q

how does it affect someones appetite? Thiamin

A

Does not increase appetite over normal

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17
Q

what disease did Takaki cure the Japanese navy of and how did he do it? Thiamin

A

less rice & more vegetables

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18
Q

what disease did Eijkman cure pigeons of and how did he do it? Thiamin

A

fed pigeons same diet as prisoners

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19
Q

what did Grijns suggest in relation to Beri Beri disease? Thiamin

A

rice have vital substance in hulls

20
Q

what did Funk discover and what did he name it? Thiamin

A

isolated and named it vital amine

21
Q

how many people suffer symptoms of Beri Beri disease? Thiamin

22
Q

what are the three places where people can be especially prone to Beri Beri? Thiamin

A

 Countries where polished rice is a staple

 Victims of political trade embargos  Displaced persons in refugee camps

23
Q

what are the three reasons people get Beri Beri? Thiamin

A

 Failure to enrich rice  Washing of rice

 Soaking of rice

24
Q

whats going on with the Karentribe in relation to Beri Beri? Thiamin

A

Thailand-Burma border; Infantile mortality is major

25
who are the three groups of people that prone to get Beri Beri in the US? Thiamin
alcoholics, low carbohydrate diets, low carbohydrate diets + tea + raw fish
26
what are the three symptoms of Beri Beri? Thiamin
Neurological changes, Mental confusion, Cardiovascular failure
27
with the symptom of Mental confusion in Beri Beri what are the five things that can happen? Thiamin
Irritability, depression, headache, fear, coma
28
with the symptom of neurological changes what are the six things that can happen? Thiamin
```  Muscle weakness and wasting  CNS creates unsteady gait  Peripheral neuritis  Decreased speed and coordination  Paresthesia  Constipation ```
29
with the symptom of neurological change in Beri Beri, Decreased speed and coordination is one of the things that can happen so what specifically happens with this? Thiamin
loss of knee/ankle jerk
30
with the symptom of neurological change in Beri Beri one of the things that can happen is constipation, what specifically happens here? Thiamin
decreased tonus of GI tract
31
what are the two different types of Beri Beri? Thiamin
infantile and adult
32
what are the three symptoms of infantile beri beri? Thiamin
Cyanosis, tachycardia, weak cry, convulsion
33
how long does infantile beri beri last and what can be a serious consequence? Thiamin
2-5 months, frequently fatal
34
who normally gets infantile beri beri? Thiamin
Often breast fed mother with low thiamin diet
35
what is cyanosis? Thiamin
symptom of infantile beri beri where blue lips occur
36
what is tachycardia? Thiamin
symptom of infantile beri beri where irregular heart beat occurs
37
what are the two different types of adult beri beri? Thiamin
Wet (Edematous), Dry (Wasting)
38
what are the two things that happens with adult Wet (Edematous) beri beri? Thiamin
 Swelling of limbs |  Accumulation of fluid in heart -> heart failure
39
what happens with dry (wasting) adult beri beri? Thiamin
Gradual loss of body tissues
40
what are the recommended requirements? Thiamin
 0.5 mg/1000 cal (minimum 1 mg for any caloric intake)  M 1.2 mg, F 1.1 mg
41
when are the two cases when you should increase your thiamin intake above the recommended amounts? Thiamin
 Pregnancy, growth, old age (problems in absorption)  Alcohol
42
what are the two reasons people who drink alcohol should increase their thiamin intake above the recommended amounts? Thiamin
 Thiamin necessary to breakdown to acetaldehyde |  Interferes with thiamin absorption
43
what is the one case where you should decrease your intake below the recommended amounts? Thiamin
High fat diet
44
why should a person with a high fat diet decrease their recommended level of this? Thiamin
Means low carbohydrates (need thiamin for | metabolism)
45
what is the toxicity symptoms? Thiamin
none known
46
what are the three main food sources? Thiamin
 Pork products  Whole grains  Enriched foods