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Flashcards in Combank path - cardio Deck (27):

What is occurring within 2-4 days post MI?

Abundant neutrophil emigration takes place to lyse dead myocardial cells and extensive coagulative necrosis takes place


What occurs 7-8 weeks post MI and what is the patient at risk for during this time?

Dense type I collagen replaces the primitive type III collagen; heart is at risk of a ventricular aneurysm b/c the scar tissue has diminished contractile properties that can become weak and bulge out to cause an aneurysm


What occurs 4-12 hours post MI?

Early coagulative necrosis is seen as neutrophils begin to migrate towards the recently infected area to degrade the tissue. Content of necrotic cells such as troponins, CK-MB, and CPK are then released into the bloodstream from the myocardial cells


What occurs 5-10 days post MI?

Macrophages begin to replace neutrophil degradation; there is extensive granulation tissue that is necrotic, soft and brown yellow; this soft necrotic tissue renders the heart susceptible to free wall rupture, tamponade, papillary muscle rupture and septum rupture


Name the valvular disorder --- harsh systolic crescendo decrescendo murmur heard best at right upper sternal border

Aortic stenosis


What is one way that aortic stenosis is differentiated from mitral regurgitation?

aortic stenosis radiates to the carotids


What is the classic triad of symptoms that is associated with aortic stenosis?

angina, syncope, heart failure


What is the most common cause of aortic stenosis in the United States?

Aortic valve calcification -- increases with age


What is the most common cause of mitral stenosis?

Rheumatic fever


What type of drugs have been shown to reduce mortality in post MI patients?

beta blockers


What is Wolff-Parkinson-White syndrome?

an accessory conduction pathway from atrial to ventricles causes premature ventricular excitation; this leads to paroxysmal tachycardia; ECG findings show short PR interval and an upward deflection before the QRS called a delta wave


A banana shaped left ventricle on echocardiogram indicates?

Hypertrophic cardiomyopathy


What type of axis deviation would show on ECG for hypertrophic cardiomyopathy?

left axis deviation


What type of dysfunction does hypertrophic cardiomyopathy cause?

asymmetrical interventricular septal hypertrophy and hypertrophy of the LV produces a diastolic dysfunction (ventricle can't fill!)


What is hemochromatosis?

an AR d/o causing increased iron absorption in the intestines


What are the most common signs of hemochromatosis at the time of presentation?

hepatomegaly, skin pigmentation, arthritis


Which cardiomyopathy can result from hemochromatosis?

dilated cardiomyopathy due to iron deposition within the myocardium


When should surgical repair of an AAA be performed

if aneurysm is ruptured; grows > 1 cm in one year; grows beyond 5.5 cm for men or 4.5 cm for women


What is Friederich's ataxia?

AR trinucleotide repeat d/o (GAA) that causes poor mitochondrial function; staggering gait, nystagmus, pes cavus and hammer toes are characteristic findings


What is the most common cause of death in Friedreich's ataxia?

hypertrophic cardiomyopathy


What is multiple myeloma?

hematologic malignancy that causes neoplastic proliferation of plasma cells resulting in overproduction of monoclonal IgG, IgA and or light chains


The secreted monoclonal immunoglobulin proteins caused by multiple myeloma can form what type of amyloid and where can they deposit?

AL amyloid; can infiltrate the myocardium causing normal sized ventricular cavities to become stiff, this leads to restrictive cardiomyopathy


Digoxin toxicity is increased by quinidine because?

it decreases digoxin's renal clearance


T/F hypercalcemia and hypokalemia increase digoxin toxicity



What class of drugs is known to increase survival of CHF?

ACE inhibitors


What is Beck's Triad and in what cardiac condition is it seen in?

Becks Triad consists of hypotension, decreased heart sounds, jugular venous distension; classically seen in cardiac tamponade


A syphilitic aneurysm is characterized by?

obliterative endarteritis of the vasa vasorum of the media; usually affects the proximal ascending aorta resulting in aortic dilation and aortic valve insufficiency