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RUSVM Pharmacology > Distribution > Flashcards

Flashcards in Distribution Deck (18):
1

"Compartments" Concept

Groups of tissues/ fluids for which the rates of update/clearance of a drug are similar; distribution of drugs involves movement between different compartments

2

Factors that affect distribution

Physiochemical properties of the drug

Concentration gradient between blood and tissue

Blood flow : tissue mass

Affinity of drug for tissue

3

Body fluids compromise ________ % of body weight

57%

4

Intracellular fluid constitutes _________%

40%

5

Extracellular fluid constitutes _____%

17%

6

Apparent Volume of Distribution

Apparent volume necessary to contain the entire amount of a drug if were evenly distributed throughout the body at the concentration present

7

Examples of tissues with high relative blood flow

Brain, Heart, Kidney, Endocrine Organs

8

Examples of tissues with low relative blood flow

Bone, Fat , inactive muscle

9

Blood Brain Barrier

Tight junctions between capillary endothelial cells and glial cells surrounding the pre capillaries force drugs to cross cell membrane to enter, CSF is constantly produced keeping space around the CNS "washed"

10

What mechanisms are responsible for drug efflux out of the CNS?

Active Transport mechanisms ___________________________

P-gp

11

Plasma protein binding is an important means of

Distribution

12

Acidic drugs bind primarily to

Albumin

13

Basic drugs primarily bind to

Alpha1-acid glycoproteins, beta-globulins and some others

14

Plasma protein binding is generally (reversible/irreversible)

Reversible

15

Bound drug is generally confined to the

Blood

16

Bound drug is (active/inactive)

Inactive

17

Other factors that affect drug distribution

Stereochemistry

Tissue binding

Rate of Metabolism

Rate of Excretion

Redistribution

18

Distribution

Transfer of drugs from the bloodstream to tissues around the body