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Flashcards in General Principles Deck (27):
1

Transmembrane movement

Diffusion through lipid membranes and aqueous protein channels in the cell membrane

2

Basic drugs ionize in (acidic/basic) environments.

Basic drugs ionize in (acidic/basic) environments.

3

Lipid/Water Partition Coefficient

Measure of the diffusional mobility of a particular molecule

4

pKa is equal to

pKa is equal to the pH of the medium at which the dissolved drug is 50% ionized and 50% nonionized

5

Gene that encodes the permeability glycoprotein system (p-gp)

MDR-1 /  ABCB-1 Gene

6

Secondary Active Transport

Uses stored energ in the Na electrochemical gradient generated by using ATP

7

Paracellular movement

Diffusion through intercellular aqueous channels

8

The cell membrane is composed of a 

The cell membrane is composed of a lipid bilayer and embeded proteins

9

Most drugs are (weak/strong) acids or bases

Most drugs are (weak/strong) acids or bases

10

Membranes are more permeable to (nonionized/ionized) forms of drugs.

Membranes are more permeable to (nonionized/ionized) forms of drugs.

11

Components of the ADME process

Absorption

Distribution

Metabolism

Elimination

12

Permeability glycoprotein system (P-gp)

Drug transporter that removes drugs after being absorbed into specific cells or tissue sites

___________________

Associated with the multple drug resistance family

13

Active transport

Carrier-mediated transport, movement is against the gradient and requires energy

14

Drug Efflux

Membrane pump that "bounces" drug out of a cell

15

Ion Trapping

Weak acids are absorbed from an acidic environment and sequestered in an alkaline medium

______________

Weak bases are absorbed from an alkaline environment and sequestered in an acidic environment

16

Transport mechanisms across cell membranes

Simple/Passive Diffusion

Facilitated Diffusion (Passive Transport)

Active Transport

Pinocytosis

17

Ionization equation for a weak acid

pKa = pH + log N/I

18

Acidic drugs ionize in (acidic/basic) environments.

Acidic drugs ionize in (acidic/basic) environments.

19

Ionization equation for a weak base

pKa = pH + log I/N

20

Disposition

Study of movment of drugs across biological membranes in the body from teh time of absorption until elimination

21

Pinocytosis

Type of endocytosis, drug binds to the surface of the membrane that then invaginates and interiorizes the drug, requires ATP

22

Channel Mediated

Transport across the membrane involves opening of ion channel proteins

23

Facilitated Diffusion

Movement with the concentration gradient, no energy required

24

What are the factors that determine whether a drug will pass through a membrane

pKa

Ionization

Solubility

pH of medium

25

Carrier-Mediated Transport

Transfer of substance across the membrane involves attachment to a specific macromolecular carrier

26

Movement with a concentration gradient moves from

Movement with a concentration gradient moves from high to low concentration

27

Primary Active Transport

Uses energy directly from ATP