Diabetes Insipidus (DI) Flashcards Preview

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Flashcards in Diabetes Insipidus (DI) Deck (13):
1

Nephrogenic diabetes insipidus is caused by

Impaired responsiveness of the kideny to ADH

2

Chlorpropamide

Thiazide Diuretic

Oral hypoglycemic sulfonylurea drug

Restricts sodium chloride intake

Not very effective in the treatment of CDI in cats and dogs

Requires the presence of endogenous ADH to act

3

Central Diabetes Insipidus is treated with

Desmopression, DDAVP

Thiazide Diuretics 

4

Actions of ADH

Stimulate reabsorption of water → increased water in ECF and decreased ECF osmolality

Stimulate the thirst center and increase water intake → increased ECF and decreased ECF osmolality

5

Drug of choice for Central Diabetes Insipidus in dogs and cats

Desmopressin, DDAVP

6

Desmopressin, DDAVP

Synthetic ADH analog

Minimal vasoconstrictor action

Given parenterally or nasal drops on conjunctival sac

7

Drug of choice for Nephrogenic Diabetes Insipidus

Thiazide Diuretics

8

T/F: Natural ADH is more potent and has longer duration of action than Desmopressin, DDAVP

False

9

Types of Diabetes Insipidus

Central Diabetes Insipidus

Nephrogenic Diabetes Insipidus

10

Central Diabetes Insipidus is caused by

ADH deficiency

11

Diabetes insipidus is commonly associated with what clinical manifestations?

Polyuria and Polydipsia

12

How is ADH stimulated to be secreted

  1. Volume contraction increases ECF osmolality
  2. Increased ECF stimulate osmoreceptors
  3. Osmoreceptors stimulate ADH Secretion

 OR

  1. Hypotension stimulate volume receptors
  2. Volume receptors stimulate ADH secretion

13

How is natural ADH used in the diagnosis of Diabetes Insipidus

Administered IM or IV over 1 hour in lactated ringers or 5% dextrose solution