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RUSVM Pharmacology > Absorption > Flashcards

Flashcards in Absorption Deck (25):
1

Tmax

Time that it takes to reach Cmax

2

Two main routes of administration

Enteral and Parenteral

3

Factors related to the animal that affect absorption

Blood flow

Absorbing surface area

Connective tissue

Species

Individual variation

Fasted vs Fed

4

Transdermal Administration

Applied topically to have systemic effect

5

Often the rate limiting step controlling absorption

Dissolution

6

Absorption

Movement of the drug from the site of administration into the blood

7

Rate of absorption is determined by

Rate of absorption is determined by gastric emptying time

8

In animals that are unable to take oral medications, sometimes they are given

In animals that are unable to take oral medications, sometimes they are given rectally

9

Excipient

What a drug is compounded with

10

Sublingual absportion bypasses the 

Sublingual absportion bypasses the portal vein

11

Factors related to the drug that affect absorption

Molecular Size

Disintegration and Dissolution

Lipid Solubility

Degree of Ionization

Concentration at the absorptive site

Route of administration

12

With respiratory administration the (upper/lower) respiratory tract is best for systemic absorption.

With respiratory administration the (upper/lower) respiratory tract is best for systemic absorption.

13

Parenteral Drug Administration Routes

IV

IM

SQ

IP

14

Disintegration

Physical dispersion of a soild dosage form

15

Drugs that absorb well when given buccal/sublingual

Dormoseden

Buprenorphine

16

Dissolution

Drug molecules enter solution

17

Rate limiting step of transdermal administration

Stratum corneum

18

First Pass Metabolism

Drugs absorbed distal to the oral cavity and proximal to the rectum enter the portal vein and then into the liver where biotransformation may occur

19

Topical drugs are generally intended to have (high/low) absorption into systemic system

Topical drugs are generally intended to have (high/low) absorption into systemic system

20

Cmax

Maximum plasma concentration of a drug

21

Topical Administration

Refers to topicall on the skin to achieve local effects 

22

Does IV administration undergo absorption?

No, its administered directly into the vein

23

Rectal administration relationship to first pass metabolism

First pass metabolism may be reduced

24

Primary site for drug absorption

Small intestine

25

AUC Graph

Plots plasma concentration of a drug at different time intervals