Flashcards in Drug-Induced Liver DZ Deck (6)
How do oral contraceptives lead to liver dz?
bland cholestasis, estrogen decreases membraine fluidity, decrease Na/K ATPase activity and bile salt transoprt
What are the liver comlications of oral contra?
hepatic vein thrombosis (budd chiari)
peliosis hepatis (blood lake)
focal nodular hyperplasia
what is the relationship between acetominophen and etoh?
etoh decreases glutathione and increases p450. there is an increase in toxic metabolites of aceto. as little at 2.5-4 gm may be toxic in alcoholics
how to use p450 levels to differentiate between alcoholic liver dz and other causes of liver dz?
other causes typically have reduced, p450 . not increased
what is given to pts suspected of tylenol overdose