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Flashcards in Drug-Induced Liver DZ Deck (6)
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1

How do oral contraceptives lead to liver dz?

bland cholestasis, estrogen decreases membraine fluidity, decrease Na/K ATPase activity and bile salt transoprt

2

What are the liver comlications of oral contra?

hepatic vein thrombosis (budd chiari)
peliosis hepatis (blood lake)
focal nodular hyperplasia

3

what is the relationship between acetominophen and etoh?

etoh decreases glutathione and increases p450. there is an increase in toxic metabolites of aceto. as little at 2.5-4 gm may be toxic in alcoholics

4

how to use p450 levels to differentiate between alcoholic liver dz and other causes of liver dz?

other causes typically have reduced, p450 . not increased

5

what is given to pts suspected of tylenol overdose

n-acetylcysteine

6

how does amiodarone present histologically in liver dz

looks like steatosis but actually myelin-like figures