Drug-Induced Liver DZ

Question 1

How do oral contraceptives lead to liver dz?

Answer 1

bland cholestasis, estrogen decreases membraine fluidity, decrease Na/K ATPase activity and bile salt transoprt

Question 2

What are the liver comlications of oral contra?

Answer 2

hepatic vein thrombosis (budd chiari)
peliosis hepatis (blood lake)
focal nodular hyperplasia

Question 3

what is the relationship between acetominophen and etoh?

Answer 3

etoh decreases glutathione and increases p450. there is an increase in toxic metabolites of aceto. as little at 2.5-4 gm may be toxic in alcoholics

Question 4

how to use p450 levels to differentiate between alcoholic liver dz and other causes of liver dz?

Answer 4

other causes typically have reduced, p450 . not increased

Question 5

what is given to pts suspected of tylenol overdose

Answer 5

n-acetylcysteine

Question 6

how does amiodarone present histologically in liver dz

Answer 6

looks like steatosis but actually myelin-like figures