Normal and Abnormal Liver Function Tests Flashcards
What lfts detect injury?
aminotransferases and alk phos
which lfts detect clearance
ammonia and bilirubin
tests of synthetic capacity of lfts
clooting factors made by liver, albumin, cholesterol - late complication of severe dysfunction
IS ast or alt more specific for liver injury?
alt
WHere is alk phos derived?
enzyme derived from bile ducts
why does alk phos increase?
increased synthesis
What is cholyglycine?
a serum bile salt that correlates with degree of cholestasis, intra or extrahepatic obstructino to bile flow
When does ggt increase?
cholestasis, biliary obstruction,
when does prothrombin time increase?
deficiency in clotting factors one two five seven ten or vit k
What are the five factors of child pugh classification?
abl bili ascited enceph pt/inr
what is MELD
moderl of end stage liver dz using inr bili and creatinine
