Gastrointestinal Regulation Flashcards
What length is gastrin that is secreted continuously? Where from?
What length with meals?
G34 continuous secretoin from duodenum
G17 with presence of meal
What chemical on gastrin is responsible for preeventing liver degradation of gastrin
nh2
when you desulfate gastrin, what does it become the same as?
gastrin
what terminal amino acid will make any peptide have some gastrin activity
tyrosine
are their any partial segments of secretin that retain activity?
nope, needs full length
where do we find gastrin?
in the atrum and duodenumw
where do we find cck?
duodenum, jejunum
where do we find GIP?
duodenum and jejunum
where is secretin
duodenum
where is motilin
duodenum and jejunum
what does VIP do?
released from mucosa and smooth muscleof GI tract that relaxes sphnicters, relaxes gut circular muslce, stimulations intestinal secretion an dpancreatic secretion
where is somatostatin from? what does it do? what triggers it?
from gi mucosa and pancreatic islets
inhibits gastrin release
stimulated by acid
where is histamine from? do? trigger it?
from the oxyntic glands (ECL-cell)
stimulates acid secretion
stimulated by gastrin
ZE syndrome?
over production of gastrin
duodenal ulcer, diarrhea, steatorrhea
high rates of acid secretion and inactivation of pancreatic lipase due to decreased ph
If the sulfated tyrosyl residue is at the sixth place from the c-terminus, what will the function be?
at the seventh?
gastrin
cck
