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Flashcards in Gastrointestinal Regulation Deck (15):
1

What length is gastrin that is secreted continuously? Where from?

What length with meals?

G34 continuous secretoin from duodenum

G17 with presence of meal

2

What chemical on gastrin is responsible for preeventing liver degradation of gastrin

nh2

3

when you desulfate gastrin, what does it become the same as?

gastrin

4

what terminal amino acid will make any peptide have some gastrin activity

tyrosine

5

are their any partial segments of secretin that retain activity?

nope, needs full length

6

where do we find gastrin?

in the atrum and duodenumw

7

where do we find cck?

duodenum, jejunum

8

where do we find GIP?

duodenum and jejunum

9

where is secretin

duodenum

10

where is motilin

duodenum and jejunum

11

what does VIP do?

released from mucosa and smooth muscleof GI tract that relaxes sphnicters, relaxes gut circular muslce, stimulations intestinal secretion an dpancreatic secretion

12

where is somatostatin from? what does it do? what triggers it?

from gi mucosa and pancreatic islets

inhibits gastrin release
stimulated by acid

13

where is histamine from? do? trigger it?

from the oxyntic glands (ECL-cell)
stimulates acid secretion
stimulated by gastrin

14

ZE syndrome?

over production of gastrin
duodenal ulcer, diarrhea, steatorrhea
high rates of acid secretion and inactivation of pancreatic lipase due to decreased ph

15

If the sulfated tyrosyl residue is at the sixth place from the c-terminus, what will the function be?

at the seventh?

gastrin

cck