Carcinoid, GI Stromal Tumor and Lymphoma Flashcards Preview

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Flashcards in Carcinoid, GI Stromal Tumor and Lymphoma Deck (16):
1

What is the pathophysiology of gastric carcinoid tumors?

chronic gastritis or gastric acid suppression leads to hypergastrinemia compensatory response. this leads to gastric diffuse neuroendocrine hyperplasia and then to tumors.

2

WHat on histology may the neuroendocrine tumor look like

sheets nests trabeculae whatever it wants

3

What is the immunostain for neuroendorcrine tumores?

chromogranin and synaptophysin

4

What the the dx criteria for ZE syndrome

fasting gastrin level about 1000 pg/ml with gastric ph below 5

secretin stumulation test with increase in gastin of more than 200 pg/ml

5

How do you tx ZE

surgery and high dose ppi

6

Where do you common see intestinal neuroendocrine tumors? In what age?

ileum and appendix, common in late middle age

7

what is carcinoid syndrome?

episodes of flushing, diarrhea, wheezing, colicky abd pain
right heart endocardial fibrosis

8

what is responsible for the efx of carcinoid syndrome

vasoactive polypeptides, serotonin

9

what is diagnostic test for carcinoid syndrome?

5-HIAA

10

what will immunostain c-kit cd117 mean

it can be treated with imatinib

11

where are GI stromal tumors most common?

in the stomach and small intestine

12

what is the common mutation in GISTs?

kit transmembrane receptor tyrosine kinase, activating it as an oncogene with positive immunostain for cd117

13

GIST presents with what sorts of things?

overt GI bleeding, abdominal mass or abd pain

14

Gastrointestinal lymphoma is associated with what/

h pylori
Ai dz
immunodificiency
celiac dz

15

how do gastrointestinal lymphomas present?

epigastric pain!!!!!
anorexia
weight loss
occult bleeding
n/v

16

what is the prognosis for MALToma?

good