Pancreas II: CF, Cystic Disorders and Cancer Flashcards Preview

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Flashcards in Pancreas II: CF, Cystic Disorders and Cancer Deck (17)
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1

What are the main symptoms of CF?

lung infections, chronic pancreatitis, hypertonic sweat

2

What is the gene defect in CF

caused by a threebase pair deletion deltaF508 that affects the folding, processing and functioning of the CF gene product, the cystic fibrosis transmembrane conductance regulator.

3

Explain the pathophys of CF

defective chloride secretion
inspissated secretory product
obstruction of ducts and lumens
infetion, inflammation and tissue destruction

4

What are clinical manifestations of CF

obstructive/inflammatory lung dz
chronic pancreatitis
hypertonic sweat ( because no reabso of cl)
hepatobiliary tract dz
meconium ileus in infants
infertility

5

What can be seen of ducts on histo in CF

several distended with dark pink secretions

6

What are clinical symptoms of CF

frequent pulmonary infections (pseudomonas)
diarrhea, malabsortion, failure to thrive bc no acinar cells
frequent episodes of dehydration

7

What are benign pancreatic cysts

pseudocysts
rare non-neoplastic cysts

8

What are cystic neoplasms of pancreas

serous cystic tumors
mucinous cyst neoplasms
intraductal papillary mucinous neoplasms
solid pesudopapillary neoplams

9

what are potentially malignant cystic lesions

mucinous cystic neoplasms
intraductal papillary mucinous neoplasms
solid pseudopapillary neoplasms

10

What type are the majority of pancreatic cancers?

adenocarcinomas of ductal origin

11

what are the common presentations of pancreatic cancer?

adb pain and weight loss

12

What is it called when pancreatic cancer results in the lack of gland formation

anaplasia

13

what are risk factors for pancreatic cancer

cigarette smoking
alcohol in setting of CP
hereditary pancreatitis
family hx

14

What are clinical features of pancreatic adenocarcinoma?

weight loss, abdominal pain and jaundice (from cbd obstruction)

15

What is a serum marker elevated in pancreatic adenocarcinomas?

CA19-9

16

where is the best place to have pancreatic cnacer?

in the head of the pancreas (which is also the most common location

17

67 yo wm smoker with weight loss and vague abd pain over 3 mos. yellow sclera. most concerned he has?

a mass in head of pancreas

think 60-70s male smoke with yellow eyes