Chronic Liver Failure II Flashcards Preview

GI > Chronic Liver Failure II > Flashcards

Flashcards in Chronic Liver Failure II Deck (10):
1

What are several proposed mechanisms of hepatic encephalopathy?

ammonia, nitrogenous wastes, increased intracellular glutamine, astrocyte swelling, cerebral edema, inflammatory cytokins alter bbb

2

what is chronic hepatic encephalopathy?

often slow and subtle on onset, family notices, coworkers wont

3

what are physical signs of encephalopathy

hyperextended the wrists and reprititive movement, inability to perform sustained grip of hand, hyperextension of he ankles

4

what is a treatment of encephalopathy

lactulose, poorly absorbable sugar, cathartic, decreases intestinal pH, decreases glutamine absorpption, reduces syntehsis and absorption of nh3

zinc, cofactor in nh3 metabolism
antibiotics - alter intestinal flora, decrease nh3

5

do people with encephalopathy need to cut down protein

nope

6

what are alzhemier type ii astrocytes?

seen in metabolic encephalopathy, large round vasicular nuceei with scanty chromatin and prominent nucleolus

7

what is hepatorenal syndrome?

a syndrome where the kidneys are not damaged yet shut down from signs from the liver. liver failure causes renal arterial vasoconstriction and renal failure

8

what do you see on labs and eval with hepatorenal syndrome?

cirrhosis and ascites
serum creat over 1.5
no imporvement

9

what are teh two types of hepatorenal syndrome?

i - rapid worsening
ii - slow progression

10

what is mpgn associated with?

hep c