Micro: H. Pylori, Vibrio, Campylobacter, and Anaerobes Flashcards Preview

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Flashcards in Micro: H. Pylori, Vibrio, Campylobacter, and Anaerobes Deck (34)
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1

What is the main cause of ulcers?

h pylori

2

how is h pylori spread

person to person fecal to oral

3

what types of cancers is h pylori associated with

gastic adenocarcinomas and lymphomas

4

What are the virulence factors of h pylori?

It's a slender, curved, gram- rod with motile polar flagella, that is microaerophilic.
It has a VacA - vacuolating cytotoxin
PAI encoding Type III secretion system
Cag - rearranges cytoskeleton
Urease

5

Pathogenesis of h pylori?

makes urease, allowing persistance, has mcular needle injecting Cag and VacA, leadining to inflammation

6

What exactly causes the ulcers in h pylori?

the cell destruction by VacA, Cag and immune response

7

What is the most common bacterial GI infection in developed nations?

Campylobacter jejuni

8

What is the reservoir for c jejuni? How many cells are needed for infxn?

sheep, cattle, chickens wild birds dogs

only a few hundred

9

What is the structure of c jejuni

thin spiral chaped gram-negative rods, with gull-winged appearance

10

what are the symptoms of c jejuni infxn/

fever, appendicits-like lower abdominal pain, watery diarrhea that progresses to dysentery with blood and pus

11

What microbe is associated with Guillen-Barre Syndrome?

c jejuni *think "camplybarre"*

12

Why is campylobacter infxn self-limiting while h pylori can last for decades?

the pathogenesis of h pylori in creating urease allows for a maintenance of hospitable environment. also, lower GI where c jejuni targets has a better clearance mechanism

13

microbiology of vibrio/

curved gram- rods motile with flagellum, oxidase positive, saltwater in warm months

14

what are the three significant vibrio classes

cholarea parahaemolyticus and vulnificus

15

Where is cholera most present?

asia, africa, s america, india

16

what serogroups of cholera are responsible for the pandemicss?

o1 and o139

17

what is the infxs dose of cholera/

more than 10^8

18

What is the presentation of cholera

abrupt onset of vomiting and high volume watery diarrhea

19

what is the characteristic description of cholera stool?

rice-water stools, speckled with mucus and loaded with bugs

20

what are the virulence factors of cholera

pai-encodid pilus
phage-encoded toxin

21

describe the toxin of cholera

ab toxin comprised of 5b and 1a subunit, causing adpp-ribosylation of gtp-biding protein. activation of adenyl cycle leading to activation of cftr

22

what are the symptoms of vibrio parahaemolyticus

water diarrhea often with abdom cramps, n/v low grade fever 24 hrs post-exposure,

23

when do we see v vulnificus

free-living in sea water with consumption of raw oysters and wound infection, leads to immunocompromised or chronic liver pts getting septicemia and bullae

24

what are the symptoms of v vulnificus

vomiting, diarrhea and abdom cramps

25

presentation of smell culture witha bscess and tissue necrosis, smelly breath. what are you thinking?

anaerboe

26

what is the structure of bacteroides fragilis?

gram- antiphagocytic capsul,

27

what is the structure of prevotella melaningenica?

gram- coccabacillus, antiphagocyte capsule,

28

what is the colony appearance of prevotella melaninogenica?

black colony

29

what does large, boxcar gram+ rods suggest?

c. perfringens, associated with gas gangrene and cellulitis and food poisoning

30

what do we mean when we say c tetani cuts a v snare?

vesicle with neurotransmitter cannot fuse with neuron membrane. preventing release of inhibitory neurotransmitters glycine and gaba, blocking postsynaptic inhibition of spinal motor reflexes